Water-soluble iron carbonyl compound, and preparation method and application thereof
A compound and aqueous solution technology, which is applied in the field of medicinal chemistry, can solve the problems of compound instability, compound is not easy to release carbon monoxide, small toxicity, etc., and achieve good biocompatibility, timing and rate controllable, and good water solubility.
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[0033] 1. Preparation of compounds
[0034] Add 2.81 g Fe in tetrahydrofuran (THF) 3 (CO) 12 and 0.94g 1-mercaptoglycerol, react at 70°C for 2h to obtain a red solution, remove the solvent (THF) by rotary evaporation, and then recrystallize the red oily product. The solvent used is a mixture of dichloromethane / cyclohexane solvent, and finally a pure red oily substance was obtained, which was tentatively named compound 1.
[0035] 2. Characterization of Compounds
[0036] The infrared spectrum of compound 1 was collected using a Varian Scimitar 600, as shown in figure 2 shown, compound 1 at 3367 cm -1 (OH stretching vibration), 2876, 2928cm -1 (CH 2 stretching vibration), 1415cm -1 (CH 2 bending vibration), 1992~2073cm -1 (C=O stretching vibration), 1262~1334cm -1 (Bending in OH plane), 561~617cm -1 (Outside bending of OH), 1031~1071cm -1 (C-O stretching vibration) has obvious absorption peaks, which can confirm that compound 1 contains OH, CH 2 , C=O and C-O stru...
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