Novel method for detecting etimicin sulfate
A technology for etimicin sulfate and preparations, which is applied in the analysis field of content and related substances, can solve the problems of unsatisfactory separation degree, low accuracy and reliability, low derivatization efficiency, etc., and is beneficial to process development. and quality, short reaction time and high derivatization efficiency
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Embodiment 1
[0030] Chromatographic conditions: chromatographic column Phenomenex Gemini NX (150×4.6mm, 5μm), mobile phase methanol: 25% glacial acetic acid (containing 0.02M sodium heptanesulfonate, adjust pH to 3.0 with ammonia water) = 61:39, flow rate: 0.8 ml / min, injection volume 10μl, detection wavelength 330nm, injection substances: test solution and control solution. As a result, etimicin and its related substances achieved baseline separation.
Embodiment 2
[0032] Chromatographic conditions: chromatographic column Agilent Zorbax C18 (250×6.6mm, 4μm), mobile phase acetonitrile: 25% glacial acetic acid (containing 0.03M sodium heptanesulfonate, adjust pH to 2.5 with ammonium acetate)=55:45, flow rate: 1.0ml / min, injection volume 15μl, detection wavelength 335nm, injection substances: test solution and control solution. As a result, etimicin and its related substances achieved baseline separation.
Embodiment 3
[0034] Chromatographic conditions: chromatographic column Diamonsil C18 (150×5.0mm, 10μm), mobile phase acetonitrile: 25% glacial acetic acid (containing 0.01M sodium heptanesulfonate, adjust pH to 3.5 with ammonium acetate)=58:42, flow rate: 0.5 ml / min, injection volume 20μl, detection wavelength 340nm, injection substances: test solution and control solution. As a result, etimicin and its related substances achieved baseline separation.
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