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Field effect transistor-based tumor diagnosis apparatus and assay method thereof

A field-effect transistor, a technology for detecting people, applied in instruments, measuring devices, scientific instruments, etc., to achieve the effects of flexible and changeable construction materials, easy miniaturization, and low energy consumption

Inactive Publication Date: 2012-05-02
HUNAN UNIV
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  • Description
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AI Technical Summary

Problems solved by technology

This method can solve the shortcomings of the existing traditional methods, and it is simpler, cheaper, faster and more sensitive to detect tumor markers in human blood

Method used

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  • Field effect transistor-based tumor diagnosis apparatus and assay method thereof
  • Field effect transistor-based tumor diagnosis apparatus and assay method thereof

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Experimental program
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specific Embodiment approach 2

[0036] Based on SnO 2 Nanowire Transistor Biochip Diagnostic Device for Cardiac Troponin in Blood:

[0037] (1) Synthesize SnO as a field effect transistor channel by hydrothermal method or CVD (Chemical Vapor Deposition) 2 One-dimensional metal oxide materials such as nanowires.

[0038] (2) The insulating gate layer of the field effect transistor is a layer of dense silicon dioxide on the silicon substrate.

[0039] (3) SnO by photolithography and magnetron sputtering 2 Metal electrodes are prepared at both ends of the nanowire as the source and drain, and then the silicon dioxide layer is scraped off on the edge of the chip to expose the silicon substrate to make the gate.

[0040] (3) SnO 2 The nanowire device was cleaned with ethanol and acetone, and then the channel part was treated with a mixed solution of hydrogen peroxide and ammonia for 10 minutes. Then the GPTMS solution was added dropwise on the channel to react for 3 hours. The antibody to cardiac troponin w...

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Abstract

A field effect transistor-based rapid human tumor diagnosis apparatus comprises a field effect transistor biochip, a microfluidic channel sample packaging system and a set of electronic detection system. The semiconductor manufacturing technology is utilized to construct a source electrode, a drain electrode and a semiconductor channel between the source electrode and the drain electrode on a silicon substrate, silane reagent is covalently modified on the channel to serve as connecting molecules, which are connected with the specific antibody protein of a certain tumor marker, a microfluidic channel which is constructed with polydimethylsiloxane is then tightly attached and packaged on the silicon substrate, and finally, the source electrode and the drain electrode are connected with the signal detection system. By assaying the tumor marker in human blood, the tumor diagnosis apparatus can rapidly, accurately and early diagnose whether a patient suffers from a certain type of cancer, and is an integrated, high-flux and portable tumor diagnosis apparatus.

Description

technical field [0001] The invention relates to a device and a detection method for quickly and early diagnosing whether a person suffers from cancer by using a field effect transistor. Background technique [0002] Cancer is a great threat to human health and life. Together with cardiovascular disease, it has become two major difficulties in medicine. Among the 6 billion people in the world, about 7 million people are newly diagnosed with cancer every year, and more than 5 million people die of cancer every year. Almost every 6 seconds, a cancer patient dies. In recent years, the incidence of cancer in my country is on the rise, and malignant tumors rank first among the causes of death in urban population. With the progress and development of medicine, the continuous improvement of diagnostic methods can make about 80-90% of cancers diagnosed, and 1 / 3 of cancer patients can be detected in the early stage. The latest authoritative conclusion made by the World Health Organ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/414
Inventor 徐成李秋红许志张恩迪陈立宝王太宏
Owner HUNAN UNIV
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