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Composition of proton pump inhibitor and gastric mucosa protective agent

A proton pump inhibitor and protective agent technology, which is applied in drug combination, pill delivery, medical preparations containing active ingredients, etc., can solve the problems of decreased patient compliance, unsatisfactory effect, and inconvenience

Inactive Publication Date: 2011-06-01
北京华禧联合科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to get the best therapeutic effect, doctors often use two or more different preparations for patients at the same time. However, it is inconvenient for patients to take two or more medicines at the same time, and the effect is not satisfactory.
In the process of treating peptic ulcer diseases, although the combined application of proton pump inhibitors and gastric mucosal protective agents has been proved to have a good curative effect, patients need to take two or more preparations at the same time when taking medicine, which often makes patients Compliance has declined, a reality that needs to be addressed urgently

Method used

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  • Composition of proton pump inhibitor and gastric mucosa protective agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Omeprazole-S isomer 10g

[0021] Mannitol 45g

[0022] Lactose 12g

[0023] Microcrystalline Cellulose 8g

[0024] Sodium hydroxide 0.3g

[0025] Low-substituted hypromellose 2.5g

[0026] Sodium phosphate 0.2g

[0027] Sodium sulfite 0.2g

[0028] Appropriate amount of carbomer

[0029] Proper amount of ethanol

[0030]Magnesium hydroxide 0.2g

[0031]

[0032] Isolation layer

[0033] Hypromellose 4g

[0034] Magnesium hydroxide 1g

[0035] Proper amount of ethanol

[0036]

[0037] Enteric coating layer

[0038] Acrylic resin 12g

[0039] Triethyl Citrate 5g

[0040] Talc powder 3g

[0041] Appropriate amount of water

[0042]

[0043] Bismuth Potassium Citrate 55g

[0044] Lactose 35g

[0045] Talc powder 4g

[0046] Magnesium Stearate 2g

[0047] Proper amount of povidone

[0048] Preparation process: fully mix the prescribed amount of S-omeprazole, mannitol, lactose, microcrystalline cellulose, low-substituted hypromellose, sodium ...

Embodiment 2

[0051] Drug layer

[0052] Blank ball core 200g

[0053] Esomeprazole Magnesium 150g

[0054] Hypromellose 75g

[0055] Appropriate amount of purified water

[0056]

[0057] Isolation layer

[0058] Drug-coated pellets 380g

[0059] Hypromellose 38g

[0060] Talc powder 65g

[0061] Appropriate amount of purified water

[0062]

[0063] Enteric coating layer

[0064] Barrier Packed Pellets 150g

[0065] Methacrylic resin 60g

[0066] Triethyl Citrate 18g

[0067] Glyceryl monostearate 3g

[0068] Polysorbate 80 0.3g

[0069] Appropriate amount of purified water

[0070]

[0071] tablet

[0072] Enteric coated pellets 90g

[0073] Sucralfate 20g

[0074] Microcrystalline Cellulose 189g

[0075] Magnesium Stearate 1g

[0076] Preparation process: The drug layer coating liquid uses hypromellose as a binder, adding esomeprazole magnesium and talcum powder to make a suspension solution, and the isolation layer coating liquid is made of hypromellos...

Embodiment 3

[0079] Omeprazole 20g

[0080] Sodium bicarbonate 1100g

[0081] Bismuth Potassium Citrate 110g

[0082] Lactose 20g

[0083] Microcrystalline Cellulose 50g

[0084] Mannitol 25g

[0085] Sodium carboxymethyl starch 2g

[0086] Micronized silica gel 1g

[0087] Magnesium Stearate 1g

[0088] Appropriate amount of flavoring agent

[0089] Proper amount of povidone

[0090] Preparation process: sieve omeprazole, sodium bicarbonate, bismuth potassium citrate, lactose, microcrystalline cellulose, mannitol, and sodium carboxymethyl starch respectively, mix well, and use povidone ethanol solution as viscous The mixture is made of soft material, granulated through a 20-mesh sieve, dried at 40°C, and the dry granules are granulated through a 18-mesh sieve, added with flavoring agent, micro-powdered silica gel, and magnesium stearate, mixed evenly, and packaged to obtain granules.

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Abstract

The invention relates to an oral pharmaceutical composition preparation for treating peptic ulcer. The composition contains an acid-sensitive proton pump inhibitor, a gastric mucosa protective agent and a pharmaceutically acceptable carrier, wherein the proton pump inhibitor exists in a stable form. The invention also relates to a preparation method of the pharmaceutical composition. In the preparation method, two medicines are combined in a fixed unit preparation, thereby simplifying the medication scheme and improving the patient compliance.

Description

technical field [0001] The invention relates to an oral pharmaceutical composition dosage form for treating peptic ulcer. The composition comprises an acid-sensitive proton pump inhibitor, a gastric mucosal protective agent and a pharmaceutically acceptable carrier, wherein the proton pump inhibitor exists in a stable form. The invention also relates to a preparation method of the pharmaceutical composition. Background technique [0002] Peptic ulcer refers to gastric and duodenal ulcers. It is generally believed that mucosal injury factors (gastric acid, pepsin, Helicobacter pylori, etc.) and protective factors (gastric mucosal blood flow, mucus barrier, and prostaglandins) are in a state of balance. sexual ulcers. Anti-peptic ulcer drugs exert anti-ulcer effects by affecting damage or protective factors. Peptic ulcer is associated with gastric Helicobacter pylori infection, weakened mucosal protection, and hyperacidity. With my country's social development, environment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K9/16A61K9/20A61K9/48A61P1/04
Inventor 不公告发明人
Owner 北京华禧联合科技发展有限公司
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