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Oral liquid preparation for treating infantile indigestion with food retention and cough and preparation method thereof

A liquid preparation and volume technology, applied in the field of medicine, can solve problems such as poor taste of preparations, achieve the effects of improving compliance, increasing water solubility, and improving taste

Active Publication Date: 2011-09-21
LUNAN HOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main contribution of the present invention is to improve the original flavoring process, through the use of cyclodextrin inclusion technology to combine flavoring with other flavoring agents, and to screen the amount of cyclodextrin, to solve the existing preparations. good question

Method used

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  • Oral liquid preparation for treating infantile indigestion with food retention and cough and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1 Preparation of Xiaoer Xiaoji Zhike Oral Liquid

[0048]1) Extraction and concentration process:

[0049] Hawthorn (fried) 1.0kg, betel nut 1.0kg, loquat leaves (honey roasted) 1.0kg, aurantium citrus 1.0kg, radish seeds (fried) 1.0kg, melon 1.34kg, Tinglizi (fried) 1.0kg, bellflower 1.0kg kg, forsythia 1.0kg, and cicada slough 0.66kg, add water to decoct twice, add 10 times the amount of water for the first time, decoct for 2.5 hours, add 8 times the amount of water for the second time, decoct for 2.0 hours; combine the decoction liquid, filter, and filtrate Concentrate under vacuum to a relative density of 1.10-1.15 (65°C), add 95% ethanol to an alcohol content of 70% (alcohol measurement), precipitate for 24 hours, filter, and concentrate the filtrate to a relative density of 1.15-1.20 (65°C) ), add 6 times the amount of purified water to dissolve and extract the precipitate for 48 hours, filter, and concentrate the filtrate under reduced pressure to a flui...

Embodiment 2

[0052] Example 2 Preparation of Xiaoer Xiaoji Zhike Oral Liquid

[0053] 1) Extraction and concentration process:

[0054] See embodiment 1;

[0055] 2) Preparation process:

[0056] Filter the water extract, add 1.0% (g / ml) activated carbon to the filtrate, heat and boil for 60 minutes, filter to remove carbon, add purified water to 10000ml, adjust the pH to 7.0, and add a total amount of 3.0% (g / ml) α -Cyclodextrin, control the inclusion temperature at 20°C, stir and inclusion for 60 minutes, filter, add 40% sucrose in the total amount of preparation to the filtrate, stir to dissolve, add purified water to prepare 10000ml, filter until the clarity is qualified, and then fill it, specifications 10ml / bottle, sterilized by circulating steam at 100°C for 60 minutes, packaged.

Embodiment 3

[0057] Example 3 Preparation of Xiaoer Xiaoji Zhike Oral Liquid

[0058] 1) Extraction and concentration process:

[0059] See embodiment 1;

[0060] 2) Preparation process:

[0061] Filter the water extract, add 1.0% (g / ml) activated carbon to the filtrate, heat and boil for 60 minutes, filter to remove carbon, add purified water to 10000ml, adjust the pH to 7.0, and add a total amount of 3.0% (g / ml) gamma -Cyclodextrin, control the inclusion temperature at 20°C, stir and inclusion for 60 minutes, filter, add 40% sucrose in the total amount of preparation to the filtrate, stir to dissolve, add purified water to prepare 10000ml, filter until the clarity is qualified, and then fill it, specifications 10ml / bottle, sterilized by circulating steam at 100°C for 60 minutes, packaged.

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Abstract

The invention discloses an oral liquid preparation for treating infantile indigestion with food retention and cough (infantile food retention removing and cough relieving oral liquid) and a preparation method thereof. In order to overcome the shortcoming of a traditional taste correcting process in the infantile food retention removing and cough relieving oral liquid, a cyclodextrin inclusion technology is adopted in the invention, and combined taste correction is carried out by utilizing other taste correcting agents; the oral liquid preparation which is suitable for pediatric medication is developed, and the industrialization of the application of the cyclodextrin inclusion technology to the production of traditional Chinese medicine oral liquid preparation is realized; the mouthfeel ofthe preparation is improved, and the medication compliance of a child is enhanced; meanwhile, the water-solubility of low-polarity effective ingredients is increased by the formation of an inclusion compound so that the quality and the stability of the preparation are enhanced.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to an oral liquid preparation for treating children with dyspepsia cough and its preparation method, which has the dual effects of eliminating food stagnation, resolving phlegm and relieving cough, and specifically relates to an oral liquid for eliminating stagnation and relieving cough in children and a preparation method thereof . Background technique [0002] Pediatric cough is one of the most common frequently-occurring diseases in children throughout the year, accounting for more than half of all outpatient visits, especially in winter. Its therapeutic drug is currently the most popular Shedan Chuanbei liquid, and there are other Laiyang pear and Chuanbei syrups. The above-mentioned medicines can cure all kinds of coughs on the surface, but they are poorly targeted, especially for the common clinical "cough due to food accumulation" in children, and they have no effective therapeutic eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K9/08A61P1/14A61P11/10A61P11/14A61K35/64
Inventor 赵志全张则平
Owner LUNAN HOPE PHARM CO LTD
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