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Bone substitute material for Ca3ZrSi2O9 coating-titanium alloy and preparation method of bone substitute material

A technology for replacing materials and titanium alloys, applied in the fields of coating, metal material coating technology, medical science, etc., can solve problems such as affecting bone tissue reconstruction, affecting long-term stability, and increasing pH value.

Inactive Publication Date: 2011-05-11
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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Problems solved by technology

However, this type of coating degrades quickly under the erosion of physiological body fluids, which affects its long-term stability; and the exchange of calcium ions with hydrogen ions in body fluids during the degradation process causes the pH value of the surrounding environment to increase, inhibiting cell growth, and further Influence bone tissue remodeling [W.Xue, X.Liu, X.Zheng, C.Ding. Invivo evaluation of plas ma-sprayed wollastonite coating. Biomaterials, 2005; 26(17): 3455-3460; C.Wu, Y. Ramaswamy, A. Soeparto, H. Zreiqat. Incorporation of titanium into calcium silicate improved their chemical stability and biological properties. J Biomed Mater Res A, 2008; 86(2): 402-410]
At present, there is no use of plasma spraying technology to deposit Ca on titanium alloy substrates, which is biologically active and can withstand long-term erosion by body fluids. 3 ZrSi 2 o 9 Related reports on biomedical coatings

Method used

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  • Bone substitute material for Ca3ZrSi2O9 coating-titanium alloy and preparation method of bone substitute material
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  • Bone substitute material for Ca3ZrSi2O9 coating-titanium alloy and preparation method of bone substitute material

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Embodiment

[0021] will analyze pure CaCO 3 , SiO 2 And commercially available high-purity ZrO 2 (produced by Hangzhou Wanjing New Material Co., Ltd., content 99.99%) according to the molar ratio of 3: 2: 1 ingredients, ball milling and mixing in water medium for 8 hours, after drying at 110 ° C, put it in a corundum crucible, and use 5 ° C / min The heating rate was raised from room temperature to 1400 °C, kept for 6 hours, and the furnace was cooled to room temperature to obtain Ca 3 ZrSi 2 o 9 For powder, after grinding, sieve the powder between 80 mesh and 200 mesh, and the particle size range of the powder is 5-60 μm. The above-mentioned sieved powder and 5wt% PVA aqueous solution are uniformly mixed at a ratio of 9:1 (mass ratio), dried and ground through an 80-mesh sieve to obtain Ca with good fluidity. 3 ZrSi 2 o 9 Powder, particle size between 10-150μm.

[0022] Preparation of Ca on cleaned and blasted Ti-6Al-4V substrates by atmospheric plasma spraying 3 ZrSi 2 o 9 Co...

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Abstract

The invention relates to a bone substitute material for a Ca3ZrSi2O9 coating-titanium alloy and a preparation method of the bone substitute material. The bone substitute material is characterized in that medical titanium and titanium alloy (Ti-6Al-4V and the like) are taken as substrates, a Ca3ZrSi2O9 coating is deposited on the surfaces of the substrates and consists of Ca3ZrSi2O9 in a monoclinic system and a glass phase, the depth of the coating is 50-420 mu m. The preparation method comprises the following steps: synthesizing Ca3ZrSi2O9 powder; and then depositing the Ca3ZrSi2O9 coating on the titanium alloy substrate by using a plasma spraying technology, wherein the bond strength of the coating and the titanium alloy is 25-35 MPa. The provided coating can induce the formation of bone-like apatite in simulation body fluid, and has good bioactivity; and the bone substitute material can be degraded slowly in Tris-HCL buffer solution and has excellent long-term stability.

Description

technical field [0001] The present invention relates to a Ca 3 ZrSi 2 o 9 Coating-titanium alloy bone replacement material and preparation method, more precisely on the titanium alloy substrate, using Ca 3 ZrSi 2 o 9 The invention relates to a ceramic powder, which uses a plasma spraying method to prepare a long-lasting and stable bioactive coating, and belongs to the field of medical bioceramic coatings. Background technique [0002] Titanium and hydroxyapatite (HA) coatings deposited on the surface of titanium alloys by plasma spraying have been widely used clinically. The titanium coating has high bonding strength with the base material, and the bonding between the metal implant and the bone tissue can be improved by preparing the porous titanium coating. However, titanium is a biologically inert material with no biological activity and cannot form osseointegration with bone tissue, which limits its clinical application. HA coating has good bioactivity and osteocon...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/06C23C4/10C23C4/11C23C4/134
Inventor 梁莹谢有桃季珩黄利平郑学斌
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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