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Salbutamol sulfate sustained-release aerosol of micropowder for inspiration and preparation method thereof

A technology of albuterol sulfate and inhalation powder spray, which is applied in the field of salbutamol sulfate sustained-release inhalation powder spray and its preparation, and can solve the problems that there are no research reports on salbutamol sulfate pulmonary sustained-release preparations.

Inactive Publication Date: 2010-11-24
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Albuterol sulfate oral sustained-release preparations are currently on the market, but there is no research report on salbutamol sulfate pulmonary sustained-release preparations

Method used

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  • Salbutamol sulfate sustained-release aerosol of micropowder for inspiration and preparation method thereof
  • Salbutamol sulfate sustained-release aerosol of micropowder for inspiration and preparation method thereof
  • Salbutamol sulfate sustained-release aerosol of micropowder for inspiration and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Get salbutamol sulfate 0.12g, chitosan 0.1g, mannitol 1.48g and leucine 0.3g to be dissolved in 100mL water, spray dry. The conditions were that the inlet temperature was 100° C., the outlet temperature was 65° C., and the nozzle air flow rate was 800 ml / min. Obtain white salbutamol sulfate powder, measure the salbutamol sulfate content, and pack in hard capsules. In vitro release curve see Figure 4 .

Embodiment 2

[0065] 0.12 g of salbutamol sulfate, 0.2 g of sodium hyaluronate, 1.4 g of lactose and 0.28 g of threonine were dissolved in 100 mL of water, and spray-dried. The conditions were that the inlet temperature was 110° C., the outlet temperature was 70° C., and the nozzle air flow rate was 800 ml / min. Obtain white salbutamol sulfate powder, measure the salbutamol sulfate content, and pack in hard capsules. In vitro release curve see Figure 5 .

Embodiment 3

[0067] Get salbutamol sulfate 0.12g, mannitol 1.26g, leucine 0.32g to be dissolved in 80ml water, phospholipid 0.3g is dissolved in 20ml ethanol, after two solutions are mixed, spray dry. The spray drying inlet temperature is 100°C and the outlet temperature is 60°C. The nozzle air flow rate is 800ml / min. Obtain white salbutamol sulfate powder, measure the salbutamol sulfate content, and pack in hard capsules. In vitro release curve see Figure 6 .

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Abstract

The invention relates to the field of medicinal preparations, in particular to salbutamol sulfate sustained-release aerosol of micropowder for inspiration and a preparation method thereof. The invention is characterized in that the salbutamol sulfate sustained-release aerosol of micropowder for inspiration consists of salbutamol sulfate, polyhydroxyl sugar alcohol, a release sustaining material and amino acid. On the basis of the conventional aerosol of micropowder for inspiration, the sustained-release aerosol of micropowder for inspiration is prepared by adding certain materials. The obtained product has in-bronchus sustained-release performance, has high dissolubility, high bulk density, good angle of repose and high atomization performance and can prevent absorbing moisture.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a salbutamol sulfate sustained-release inhalation powder and a preparation method thereof. Background technique [0002] Asthma is a chronic airway inflammation involving a variety of cells, especially mast cells, eosinophils and T lymphocytes. This inflammation can cause repeated attacks of wheezing, shortness of breath, chest tightness, and / or coughing. Salbutamol sulfate is a beta 2 Adrenergic receptor agonist can relax bronchial smooth muscle; it can also stabilize mast cells and basophils, inhibit the release of allergic mediators, thereby reducing bronchospasm and respiratory mucosal congestion and edema caused by these mediators. It is mainly used clinically For the treatment of asthma, chronic obstructive pulmonary disease, pneumonia and other diseases. [0003] Albuterol sulfate dosage form that has been listed on the market mainly contains oral dosage form ...

Claims

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Application Information

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IPC IPC(8): A61K31/137A61K9/72A61K47/42A61K47/36A61K47/34A61K47/24A61P11/06A61K47/26A61K47/16A61K47/10
Inventor 汤玥朱家壁姜力群王勉
Owner CHINA PHARM UNIV
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