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Rhodiola rosea polyphenol microcapsule and preparation method

A technology of Rhodiola rosea and microcapsules, which is applied in the field of microcapsules made of polyphenolic substances and plant active ingredients, which can solve the problems of reducing the use effect, improve stability, broaden the scope of application, prolong The effect of stability

Inactive Publication Date: 2010-07-07
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, if oxidation occurs during the storage, transportation and processing of polyphenolic substances, its use effect will be greatly reduced

Method used

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  • Rhodiola rosea polyphenol microcapsule and preparation method
  • Rhodiola rosea polyphenol microcapsule and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Take 100g of dried rhizome powder of Rhodiola rosea of ​​60 mesh, add 10 times the concentration of 70% ethanol and stir well, extract in reflux water bath at 50°C for 2h, centrifuge at 4000rpm for 15min, collect the supernatant, and concentrate at 40°C by rotary evaporator to the original 1 / 20 of the volume, polyphenol crude extract.

[0040] The obtained Rhodiola rosea polyphenol crude extract was treated with D 101 Purification by macroporous resin adsorption chromatography. First eluted with 2BV (column volume) distilled water, then 3BV 50% ethanol water, the flow rate of the eluent was 2BV / h, collected the eluate containing polyphenols, and evaporated to dry ethanol in a rotary evaporator at 38°C. Vacuum-dried at 35°C to obtain the polyphenol extract of Rhodiola rosea.

[0041] Weigh 3 g of Rhodiola rosea polyphenol extract and add it to 10 mL of 95% ethanol to fully dissolve, and the polyphenol solution (core material) is set aside. Weigh 6g of soybean protein ...

Embodiment 2

[0045] Take 100g of dried rhizome powder of Rhodiola rosea of ​​80 mesh, add 20 times the concentration of 60% ethanol and stir thoroughly, reflux in a water bath at 50°C for 2h, centrifuge at 4000rpm for 15min, collect the supernatant, and concentrate it at 40°C by a rotary evaporator to the original 1 / 30 of the volume, polyphenol crude extract.

[0046] The obtained Rhodiola rosea polyphenol crude extract was treated with D 101 Macroporous resin adsorption chromatography for separation and purification. First elute with 2BV (column volume) distilled water, then elute with 3BV50% ethanol water, the flow rate of the eluent is 2BV / h, collect the eluate containing polyphenols, and evaporate the ethanol to dryness in a rotary evaporator at 38°C, 35 ℃ vacuum drying to obtain rhodiola rosea polyphenol extract.

[0047] Weigh 4 g of Rhodiola rosea polyphenol extract and add to 20 mL of 95% ethanol to fully dissolve, and the polyphenol solution (core material) is set aside.

[004...

Embodiment 3

[0052] Take 100g of dry rhizome powder of Rhodiola rosea of ​​40 mesh, add 25 times the concentration of 50% ethanol and stir thoroughly, reflux in a water bath at 50°C for 2h, centrifuge at 4000rpm for 15min, collect the supernatant, and concentrate it at 40°C by a rotary evaporator to the original 1 / 40 of the volume, polyphenol crude extract.

[0053] The obtained Rhodiola rosea polyphenol crude extract was treated with D 101 Purification by macroporous resin adsorption chromatography. First elute with 2BV (column volume) distilled water, then elute with 3BV60% ethanol water, the flow rate of the eluent is 2BV / h, collect the eluate containing polyphenols, and evaporate it to ethanol in a rotary evaporator at 38°C, 35 ℃ vacuum drying to obtain rhodiola rosea polyphenol extract.

[0054] Weigh 8g Rhodiola rosea polyphenol extract and add 30mL95% ethanol to fully dissolve it, and the polyphenol solution (core material) is set aside.

[0055] Weigh 10g of modified starch and ...

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Abstract

The invention discloses a Rhodiola rosea polyphenol microcapsule and a preparation method. The method comprises: taking extractive of the Rhodiola rosea polyphenol as core materials; taking the uniform mixture of beta-cyclodextrin, glutin, sodium alga acid, modified starch and the like as wall materials; dissolving the core materials with ethanol; dissolving the wall materials with water; mixing the core materials and the wall materials and stirring uniformly; and dispersing the mixture uniformly with a high-speed disperser to obtain the Rhodiola rosea polyphenol microcapsule by spraying and drying. The preparation method of the Rhodiola rosea polyphenol microcapsule of the invention improves the stability of the Rhodiola rosea polyphenol, avoids the damage of the outside environmental factors such as oxygen gas, humidity level, heat, light, some metal materials and the like to the Rhodiola rosea polyphenol, prolongs the storage period and the stability of the Rhodiola rosea polyphenol during the processing course, and simultaneously can also lighten the biter taste of the Rhodiola rosea polyphenol.

Description

technical field [0001] The invention relates to a method for making microcapsules from plant active ingredients and an application thereof, belonging to the field of biochemical industry. More specifically, it relates to a microcapsule of polyphenols extracted from rhizomes of Rhodiola rosea and a preparation method. Background technique [0002] Rhodiola is a perennial herb belonging to the genus Rhodiola (Rhodiola L.) of Crassulaceae. There are about 90 species of Rhodiola, and there are more than 70 species in my country, distributed in southwest, northwest, north and northeast regions. Among them, Tibet has the most distribution, about 34 species, about 27 species in Sichuan, about 26 species in Yunnan, Gansu, Xinjiang, Qinghai, Shaanxi, Heilongjiang, Jilin, Inner Mongolia, Shanxi, Hebei and Beijing are also distributed. [0003] Rhodiola contains polyphenols such as quercetin, kaempferol, isoquercetin, catechol, epicatechin, gallic acid and their derivatives. Knekt P...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61K9/50A61K8/97A61P9/10A61P7/02A61P9/00A61P39/06A61P35/00
Inventor 龚钢明王化田姜小峰
Owner SHANGHAI INST OF TECH
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