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Coenzyme Q10 water dispersion and preparation method thereof

A technology of dispersion and coenzyme, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of hidden safety hazards, high cost, and large dosage to ensure safety, Effects of safe and fair use

Active Publication Date: 2008-10-22
浙江一新制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

coenzyme Q 10 Preparation into water dispersion is a method to improve bioavailability. Domestic patents use physiologically active antioxidants to protect coenzyme Q 10 , there is a certain security risk
Foreign patents are mainly Japanese patents. WO2006134970 uses a large amount of sucrose fatty acid ester as an emulsifier, which is costly and excessively used. There are potential and unknown unsafe factors. Other patents also have some problems with the use of organic solvents.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Take 20g of gelatin, dissolve it in water, add 20g of microporous starch, 15g of arabinose, and 5g of sucrose ester, heat to 65°C-75°C, and stir to dissolve. Coenzyme Q 10 (the content is more than 99%) 7g is mixed with polyethylene glycol 60003g, heated to 65°C-75°C, stirred and melted, mixed with the solution prepared above, ground evenly with a colloid mill, and then used a high-pressure homogenizer at 120Mpa Homogenize the colloid twice. The colloid is spray-dried at an inlet air temperature of 150°C to 190°C, and the outlet air temperature is controlled at 80°C to 90°C. Get Water Dispersion Powder, Coenzyme Q 10 The content is 10.1%.

Embodiment 2

[0021] Take 20g of tragacanth gum, add water to dissolve it, add 20g of pregelatinized starch, 15g of D-galactose, and 1g of sodium lauryl sulfate, heat to 65°C-75°C, and stir to dissolve. Coenzyme Q 10 (the content is more than 99%) 20g is mixed with 600010g of polyethylene glycol and 10g of soybean oil, heated to 65 ℃ ~ 75 ℃, stirred and melted, mixed with the solution prepared above, ground evenly with a colloid mill, and then homogenized by high pressure The machine homogenizes the colloid twice under 180Mpa. The colloid is spray-dried at an inlet air temperature of 160°C to 220°C, and the outlet air temperature is controlled at 80°C to 90°C. Get Water Dispersion Powder, Coenzyme Q 10 The content is 20.2%.

Embodiment 3

[0023] Take 20g of pectin, add water to dissolve it, add 20g of pure gelatin starch, 5g of sucrose, and 801g of Tween-801g, heat to 65°C-75°C, and stir to dissolve. Coenzyme Q 10 (the content is more than 99%) 30g is mixed with 10g of polyethylene glycol 6000 and 10g of soybean oil, heated to 65°C-75°C, stirred and melted, mixed with the solution prepared above, ground evenly with a colloid mill, and then homogenized with a high pressure The homogenizer is used to homogenize the colloid twice under 220Mpa. The colloid is spray-dried at an inlet air temperature of 180°C to 220°C, and the outlet air temperature is controlled at 90°C to 100°C. Get Water Dispersion Powder, Coenzyme Q 10 The content is 29.8%.

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Abstract

The invention relates to a coenzyme Q10 water dispersion and a preparation method thereof, which is composed of coenzyme Q10, pectin substances, emulsifier, polyethylene glycol or poloxamer and other excipients which are all edible, the hot-melt mixture of the coenzyme Q10 and the polyethylene glycol or the poloxamer is further mixed with the mixture of the pectin substances, sugar, the emulsifier and soluble starch, the heating and the heat preservation are carried out, after that, a colloidal mill and a high-pressure homogenizer or a high-speed shear emulsion mixer are used for homogenizing to prepare an even colloid; and the coenzyme Q10 water dispersion is finally prepared by spray drying. The coenzyme Q10 water dispersion and the preparation method are characterized in that the bioavailability is high, all the used excipients are edible, the safety is good, the whole preparation process does not use any organic solvent or antioxidant, thus having no pollution on the product and the environment caused by the organic solvents, having small production difficulty and being applicable to the industrial production.

Description

technical field [0001] The present invention relates to aqueous dispersion and preparation method thereof, specifically a kind of containing coenzyme Q 10 Aqueous dispersions and methods for their preparation. Background technique [0002] coenzyme Q 10 It exists in the mitochondrial inner membrane of many advanced animals and plants, mainly human beings. It plays the role of transferring hydrogen in the respiratory chain, can promote oxidative phosphorylation, and can be used as an activator of cell metabolism and cellular respiration. It is also an important antioxidant and has protective properties. The structural integrity of the biofilm and the functions of enhancing immune response, and improving myocardial energy metabolism, anti-fatigue, etc. are also suitable for adjuvant treatment of various diseases such as coronary heart disease, arrhythmia, diabetes, and periodontitis. coenzyme Q 10 The reports of special effects in the treatment of Parkinson's disease, cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/122A61K47/36A61K47/42A61K47/34A61K47/44A61P9/06A61P9/10A61P3/10A61P1/02A61P25/16A61P35/00A61K47/10
Inventor 郑亚津林军吕建华
Owner 浙江一新制药股份有限公司
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