Preparation method and application of macropore-mesoporous silicon dioxide hollow micro-sphere

Abstract

Disclosed are a preparation method and application of macroporous-mesoporous silicon dioxide hollow microsphere, which relate to the field of inorganic materials preparation and pesticide application. The process of materials preparation includes adding templates P123 in aqueous phase, after generating steady oil-water-oil dual emulsion, adding silica source tetraethyl ortho-silicate TEOS, producing hydrolysis under the effect of precipitant, generating silicon dioxide hollow microsphere, after filtering and drying, the product of the invention can be produced via calcining in 550 DEG C for 6 hours. The silicon dioxide hollow microsphere of the invention has macroporous structure and mesoporous structure. Through the mesoporous structure of the microsphere wall, realizing the communication between the hollow inside of the microshere and the outside. The invention also relates to the application in area of release carrier of the materials as avermectin drugs, the prepared release controlling agent has perfect long-acting slow release performance.

Description

technical field [0001] The invention belongs to the fields of inorganic material preparation and pesticide application, and specifically relates to a macroporous-mesoporous silicon dioxide hollow microsphere, a preparation method thereof, and an application thereof as a slow-release drug carrier. Background technique [0002] Hollow microspheres have attracted widespread attention due to their special structure and morphology. Hollow silica microsphere material is a new type of inorganic porous material. Due to its unique hollow structure, the density of the material is reduced, the specific surface area is increased, and it has high purity, low density, surface silanol groups and active silane Bonds can form hydrogen bonds of different strengths and other special properties, and the cost is low, and the preparation process is relatively simple, so they are widely used in rubber, pesticides, medicine, papermaking, plastic processing, coatings, insulation, heat insulation, ca...

AI Technical Summary

Problems solved by technology

In the Chinese Patent Application No. 200610117755.5, which is named as a synthetic method of porous silica hollow microspheres, a method for preparing silica hollow microspheres by using a one-step emulsification method to obtain an oil / water / oil double emulsion as a template is proposed , but the diameter of the microspheres prepared by this method and the controllability of the hollow pore size are not good; H.J.Liu et al. In the middle water phase of the water / oil double emulsion, the cuprous oxide hollow microspheres were prepared by reacting under the action of microwave; M.H.Lee et al. Add ethyl orthosilicate to the prepared oil / water / oil double emulsion to react to form silica hollow microspheres

However, in the current drug loading methods, most of the silica carriers used are pure mesoporous materials, and the internal and external pores of the carrier are all mesoporous structures, which makes it difficult for the drug to enter the surface pores of the carrier during the drug loading process. The large mass transfer driving force is used to realize the further loading of the drug, so that the final loading of the drug is not high, the sustained release period is short, and the effective action time of the drug is short, which cannot meet the needs

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