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Antibiotic packaging material with release controlling function

A packaging material and controlled release technology, which is applied in the field of preparation of antibacterial packaging materials to reduce direct contact and overcome short duration.

Inactive Publication Date: 2008-06-04
BEIJING INSTITUTE OF GRAPHIC COMMUNICATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In summary, there is no precedent for the research and development of controlled release antibacterial active packaging materials by combining polymer surface modification and controlled release technology at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The size is 5×5cm 2 1. A low-density polyethylene (LDPE) film with a thickness of about 50 μm is ultrasonically cleaned in absolute ethanol for 3 times, each time for 5 minutes, and then air-dried naturally. Put the cleaned film into a plasma discharge device with a frequency of 13.56MHz, pressure 60Pa, discharge power 100W, CO 2 Under the condition of gas flow rate 50cc / min, process for 90s. The carboxyl group concentration on the surface was determined by the toluidine blue method to be 7.3×10 -9 mol / cm 2 .

[0020] Weigh 0.05g of chitosan powder with a deacetylation degree of 88% and 0.11g of carboxyl-terminated polyethylene glycol with a number average molecular weight of 800, add 5ml of deionized water, and stir magnetically at room temperature to obtain a transparent and clear solution. Take 0.5ml of the above solution, add 0.008g of 1-ethyl-3-(3,3-dimethylaminopropyl) carbodiimide hydrochloride (EDC. g nisin, quickly disperse for 1 min; then take 0.3ml of th...

Embodiment 2

[0023] The size is 5×5cm 2 1. The LDPE film for food packaging with a thickness of about 50 μm is ultrasonically cleaned in absolute ethanol for 3 times, each time for 5 minutes, and then air-dried naturally. Put the cleaned film into 10% ammonium persulfate aqueous solution, 80°C, N 2 Activate under purging for 90 minutes (hydroxyl functional groups are formed on the surface), take it out and ultrasonically clean it with deionized water for 3 times, each time for 5 minutes. Then put the film in 30ml of 5 vol.% acrylic acid aqueous solution, add 1ml of 2mM ceric ammonium nitrate aqueous solution, react at 30°C for 6h, take it out and ultrasonically clean it with deionized water for 3 times, each time for 10min. Then use the toluidine blue method to measure the surface carboxyl concentration to be 8.0×10 -8 mol / cm 2 .

[0024] Weigh 0.05g of chitosan powder with a degree of deacetylation of 88% and 0.13g of carboxyl-terminated polyethylene glycol with a number average molec...

Embodiment 3

[0027] The size is 5×5cm 2 1. The LDPE film for food packaging with a thickness of about 50 μm is ultrasonically cleaned with absolute ethanol for 3 times, each time for 5 minutes, and then dried naturally. Put the cleaned film into a plasma discharge device with a frequency of 13.56MHz, and treat it for 120s under the conditions of pressure 60Pa, discharge power 100W, and Ar gas flow 30cc / min (to form hydrogen peroxide groups on the surface). Then put the film in 30ml of 6.7vol.% acrylic acid aqueous solution, add 1ml of 0.01M ferrous ammonium sulfate aqueous solution, react at 30°C for 6h, take it out and wash it with deionized water ultrasonically for 3 times, each time for 10min. Then use the toluidine blue method to measure the surface carboxyl concentration to be 5.8×10 -8 mol / cm 2 .

[0028] Weigh 0.05g of chitosan powder with a degree of deacetylation of 88% and 0.15g of carboxyl-terminated polyethylene glycol with a number average molecular weight of 800, add 5ml o...

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PUM

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Abstract

The invention relates to a preparation method of an aceptic packaging material with a release-controlling function, particularly comprising three steps: firstly, a chemical surface modifying method is adopted to cause the surface of polymer packaging materials to form certain amount of dissociable functional groups such as carboxyl, sulfonic group, amidine, etc; meanwhile, antibacterial agent nisin is coated inside chitosan hydrogel microspheres which employ carboxyl polyethylene glycol as crosslinking agent, employ water-soluble carbodiimide hydrochloride as coupling agent and have particle size smaller than 100nm; in mixed solvent with 100 / 0-50 / 50 of water / ethanol, the drug-coating chitosan microspheres through ultrasonic stirring processing is 'fixed' on the surface of modified polymer thin films through electrostatic absorption between cathodic anodic ion. Since the surface modifying methods and chitosan hydrogel formulas are different, the releasable nisin amount can reach 0.5-40 Mu g / cm<2>.

Description

technical field [0001] The invention relates to a preparation method of an antibacterial packaging material with controlled release function for food packaging. The purpose of food packaging is to provide a reliable guarantee for the production, distribution and consumption of food. On the premise of ensuring safety, improving the senses of packaged food and prolonging the shelf life is the eternal pursuit of food packaging technology. Plastic flexible packaging and containers occupy a dominant position in the field of food packaging, but the current existing plastic packaging materials can only passively provide physical protection for the packaged food. Using active packaging technology to realize the controlled release of active substances—antibacterial agents is expected to achieve safe and efficient purposes. Existing research mainly adopts the method of surface coating and intelligent blending to achieve the above goals, but the experimental results are not very satisfa...

Claims

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Application Information

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IPC IPC(8): C08J7/16C08J3/075C08L5/08
Inventor 张勇许文才曹国荣刘全校
Owner BEIJING INSTITUTE OF GRAPHIC COMMUNICATION
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