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Aspirin slow-release tablet and its prepn. method

A technology of aspirin and sustained-release tablets, applied in the field of human medicine, can solve the problems of seldom application, large dose, gastrointestinal bleeding, etc., and achieve the effects of improving compliance, improving absorption rate, and prolonging action time.

Active Publication Date: 2009-06-17
哈尔滨格拉雷药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As an antipyretic and analgesic, aspirin has been used clinically for more than 100 years. Because it is used in large doses for antipyretic and analgesic, it is easy to cause gastrointestinal bleeding. seldom used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0400] Aspirin sustained-release tablet, its composition includes: aspirin, starch, hypromellose, polyacrylic acid resin No. II, white dextrin, talcum powder, tartaric acid, Tween-80, 75% ethanol, the above The weight ratio of the ingredients is aspirin 50, starch 1, hypromellose 2.48, polyacrylic resin II No. 3.6, white dextrin 1, talcum powder 3, tartaric acid 0.21, Tween-80 is 0.15, 75 % ethanol 12.

[0401] Administration method and dosage, take 50-150mg (1-3 tablets) orally each time, once a day or follow the doctor's advice.

Embodiment 2

[0403] The preparation process of above-mentioned aspirin slow-release tablet, get hypromellose 0.48, polyacrylic acid resin II No. 0.6, tartaric acid 0.21, Tween-80 are 0.15, 75% ethanol 12 and are mixed with solution, as adhesive In addition, take aspirin 50, starch 1, hypromellose 2, polyacrylic resin II No. 3, and white dextrin 1, put them in a mixer for 10 minutes, and then add agent, wet mixed for 100 seconds to make a soft material, mechanically granulated with a 20-mesh screen, dried in a boiling dryer, and the temperature of the air inlet was controlled not to exceed 100°C, adding talcum powder 3 to the dry granules, and granulated with a 18-mesh screen. The prepared granules are compressed into tablets by a press to obtain aspirin sustained-release tablets.

Embodiment 3

[0405] In the bioavailability test of aspirin sustained-release tablets, single-dose administration testers were randomly divided into two groups (A, B), and carried out according to crossover experiments. Group A was self-made sustained-release tablets, and group B was enteric-coated tablets. The interval between each dose is one week. The subject first collects blood on an empty stomach in the morning, and then takes the medicine with 150ml of warm water. The blood collection time is 0, 1, 1.5, 2, 3, 4, 5, 6, 8, 10, 12, 24 Hours, take venous blood, after processing, take plasma, store it at low temperature, and measure it by HPLC.

[0406] Drug source: test drug, each aspirin sustained-release tablet contains 50 mg of the main drug, and the actual content is 101.20%. The reference substance, aspirin enteric-coated tablets (25mg / tablet), with an actual content of 100.86%, was produced by Jinan No. 3 Pharmaceutical Factory.

[0407] Dosage: single dose of aspirin sustained-rele...

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PUM

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Abstract

A slow-release aspirin tablet for treating transient cerebral ischemia attack, myocardial infarction, thrombosis, unstable angina pectoris, etc is proportionally prepared from aspirin, starch, hydroxypropyl methylcellulose, polyacrylic resin No.2, white dextrin, tartaric acid, tween-80 and alcohol. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a human medicine, which is an oral aspirin slow-release tablet. Background technique: [0002] Antithrombotic drugs are a large category of cardiovascular and cerebrovascular drug management systems. The commonly used clinical drugs include heparin, streptokinase, urokinase, dicoumarin, and dipyridamole. Different drugs have different anticoagulant effects. Mechanism, most drugs interfere with a certain link in the blood coagulation process by participating in biochemical reactions in the human body. As an antipyretic and analgesic, aspirin has been used clinically for more than 100 years. Because it is used in large doses for antipyretic and analgesic, it is easy to cause gastrointestinal bleeding. has rarely been applied. However, studies in recent years have shown that small doses of aspirin can directly inhibit the aggregation of platelets, thereby producing an anticoagulant effect. Since the production of aspirin has a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/616A61K9/22A61P7/02
Inventor 张利
Owner 哈尔滨格拉雷药业有限公司
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