In accordance with various embodiments of the disclosed subject matter, a method and a system for detecting multiple objects from real-time images are provided. The method comprises: performing, using a CPU host, an image segmentation process to divide real-time input images into a plurality of image partitions; performing, by multiple GPUs, a fast block-wise registration process, a mark setting process, a background generation process, a foreground generation process based on a Hyper-Q computation infrastructure, and a support vector machine classification process; and generating, by the CPU host, visualization classification images.