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45results about How to "Less utilization" patented technology

B-cell reduction using CD37-specific and CD20-specific binding molecules

The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.
Owner:APTEVO RES & DEV LLC

Non-contact seal for a gas turbine engine

A seal comprises the combination of a primary seal and a secondary seal each of which acts on at least one shoe that is installed with clearance relative to one of a rotor and a stator in a position to create a non-contact seal therewith. The at least one shoe is provided with a surface geometry and labyrinth-type teeth that influence the inertia of fluid flowing across the seal, and, hence, the velocity of the fluid and the pressure distribution across the seal, ultimately affecting the balance of forces applied to the seal.
Owner:SIEMENS ENERGY INC

Non-contact seal for a gas turbine engine

A seal comprises the combination of a primary seal and a secondary seal each of which acts on at least one shoe that is installed with clearance relative to one of a rotor and a stator in a position to create a non-contact seal therewith. The at least one shoe is provided with a surface geometry and labyrinth-type teeth that influence the inertia of fluid flowing across the seal, and, hence, the velocity of the fluid and the pressure distribution across the seal, ultimately affecting the balance of forces applied to the seal.
Owner:SIEMENS ENERGY INC

Hydrodynamic brush seal

A hybrid brush seal is provided having two bundles of axially spaced seal bristles each of which are mounted in a ring shape on a first machine component with bristle ends directed at a sealing surface of the second, rotating machine component. The bristle ends are kept from direct contact with the rotating machine component via one or more shoes which are designed such that as the shaft rotates a hydrodynamic film separates the shoe(s) from the shaft. The shoe(s) is attached to the bristle ends at discreet locations. Alternatively, one or more bundles of seal bristles are mounted at one end either to the fixed or rotating machine component, with the opposite bristle ends directed toward one or more shoes, and wherein one or more spring elements are connected between the machine component and shoes.
Owner:SIEMENS ENERGY INC

Seal with stacked sealing elements

A hybrid seal for sealing the circumferential gap between a first machine component and a second machine component comprises at least one shoe extending along one of the machine components in a position to create a non-contact seal, at least one spring element connected between one of the machine components and the shoe(s) and a stack of sealing elements located within a slot formed in the shoe(s), wherein a primary seal and secondary seal of the circumferential gap is created by the shoe(s) in cooperation with the spring element(s) and sealing elements, respectively.
Owner:SIEMENS ENERGY INC

B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules

The present invention generally provides methods for B-cell reduction in an individual using CD37-specific binding molecules. In particular, the invention provides methods for B-cell reduction using CD37-specific binding molecules alone, or a combination of CD37-specific binding molecules and CD20-specific binding molecules, in some instances a synergistic combination. The invention further provides materials and methods for treatment of diseases involving aberrant B-cell activity. In addition, the invention provides humanized CD37-specific binding molecules.
Owner:TRUBION PHARM INC

Hydrodynamic brush seal

A hybrid brush seal is provided for sealing a circumferential gap between two machine components that are relatively rotatable with respect to each other having seal bristles mounted in a ring shape on a first machine component with bristle ends directed at the sealing surface of the second, rotating machine component. The bristle ends are kept from direct contact with the rotating machine component via one or more shoes which create a non-contact seal with the rotating machine component which is enhanced by the imposition of one or more spring elements connected between the machine component and shoes.
Owner:SIEMENS ENERGY INC

Seal with stacked sealing elements

A hybrid seal for sealing the circumferential gap between a first machine component and a second machine component comprises at least one shoe extending along one of the machine components in a position to create a non-contact seal, at least one spring element connected between one of the machine components and the shoe(s) and a stack of sealing elements located within a slot formed in the shoe(s), wherein a primary seal and secondary seal of the circumferential gap is created by the shoe(s) in cooperation with the spring element(s) and sealing elements, respectively.
Owner:SIEMENS ENERGY INC

De novo or “universal” sequencing array

The present invention describes a novel nucleic acid sequencing reagent which consists of a capture moiety, a spacer region and a sequence specific hybridizing region of 4-8 bases. The nucleic acid sequencing reagent of the present invention can also contain an attachment moiety. The nucleic acid sequencing reagent can be arranged into a nested array. This array configuration can then be used to sequence a given template without prior knowledge (de novo) of the wild type or expected sequence in conjunction with primer extension in the presence of a labeled chain terminating nucleotide.
Owner:BECKMAN COULTER INC

Non-contact seal for a gas turbine engine

A seal comprises the combination of a primary seal and a secondary seal each of which acts on at least one shoe that is installed with clearance relative to one of a rotor and a stator in a position to create a non-contact seal therewith. The at least one shoe is provided with a surface geometry that influences the inertia of fluid flowing across the seal, and, hence, the velocity of the fluid and the pressure distribution across the seal, ultimately affecting the balance of forces applied to the seal.
Owner:SIEMENS ENERGY INC

Apparatus and method for testing memory in a microprocessor

An apparatus and method are provided for testing memory circuits in a microprocessor. The apparatus includes test management logic and test execution logic located within the microprocessor. The test management logic has a non-specific test program stored therein, and it accepts test parameters provided by an external test controller. The test parameters are applied to the non-specific test program to produce a specific test program by inserting the test parameters in place of a plurality of non-specific test operands. The test execution logic executes the specific test program to test the memory circuits within the microprocessor at the internal speed of the microprocessor.
Owner:IP FIRST

Materials and methods for improved immunoglycoproteins

Immunoglycoproteins, including antibodies, with improved ADCC and altered glycosylation patterns are provided. Also provided are cell culturing methods and media for producing such immunoglycoproteins, and therapeutic uses of such immunoglycoproteins.
Owner:APTEVO RES & DEV LLC

Hydrodynamic brush seal

A hybrid brush seal is provided having two bundles of axially spaced seal bristles each of which are mounted in a ring shape on a first machine component with bristle ends directed at a sealing surface of the second, rotating machine component. The bristle ends are kept from direct contact with the rotating machine component via one or more shoes which are designed such that as the shaft rotates a hydrodynamic film separates the shoe(s) from the shaft. The shoe(s) is attached to the bristle ends at discreet locations. Alternatively, one or more bundles of seal bristles are mounted at one end either to the fixed or rotating machine component, with the opposite bristle ends directed toward one or more shoes, and wherein one or more spring elements are connected between the machine component and shoes.
Owner:SIEMENS ENERGY INC

Hydrogen production method

A method of producing a hydrogen product stream in which a steam stream is reacted with a hydrocarbon containing stream within a steam methane reformer. The resulting product stream is subjected to a water gas shift reaction and then to pressure swing adsorption to produce the hydrogen product stream. The hydrocarbon stream is alternatively formed from a first type of feed stream made up of natural gas, refinery off-gas, naphtha or synthetic natural gas or combinations thereof and a second type that is additionally made up of a hydrogen and carbon monoxide containing gas. During use of both of the types of feed streams, the flow rate of the steam stream is not substantially changed and reformer exit temperatures of both the reactant and the flue gas side are held essentially constant.
Owner:PRAXAIR TECH INC

Outgoing call handling system and method

A cellular system for handling outgoing calls from a mobile station (1) including, a network element (8) being capable of recognizing voiced commands and names, and has in memory a database of telephone numbers corresponding to an array of names. The mobile station (1) connects to the network element (8) and the mobile station user communicates the desired outgoing call function to the network element (8) by voice. This desired outgoing call function may be communicated while the mobile station (1) is engaged in using supplementary services provided by the network element (8), at any operation point in those services. The network element (8) evaluate the voice communication, retrieves any corresponding information, including telephone numbers, and communicates the necessary information need by the mobile station (1) to carry out the desired function to the mobile station (1).
Owner:BELLSOUTH INTPROP COR

Programmable precision current controlling apparatus

The present invention is a circuit for controlling current. In one embodiment, the high reference voltage input of a digital to analog converter is coupled with a reference voltage source which provides a positive reference voltage. A resistive load is coupled to an output of the digital to analog converter and to a circuit output pin. A sensing device couples the circuit output pin with the low reference voltage input of the digital to analog converter and to a reference ground input of the voltage source. The positive reference voltage, low reference voltage, and reference ground voltage are changed in response to the sensing device detecting a change in the output voltage.
Owner:ADVANTEST CORP

Portable ultrasonic cleaner

The portable cleaning device of the present invention utilizes a forward housing which includes an ultrasonic radiator and an ultraviolet radiator. A rearwardly located detergent spray reservoir can be used to optionally apply what may preferably be a dilute solution of soap material. Once solvent is added to the soiled area, the ultrasonic front located area can be placed in contact with the wetted garment area and energized to bring the ultrasonic radiator into direct contact with the solution in contact with the soiled area. This enables less energy to be utilized due to the close proximity to a limited liquid volume in the immediate area of the fabric and closely co-located with the soiled mass. Actuation of a ultraviolet radiator is activated simultaneously with the actuation of the ultrasonic radiator to begin to help with the odor problem from the outset of the cleaning activity. The combination of ultrasonic and ultraviolet energy input also provides energy to the solvent within the fabric to both increase the efficiency of cleaning and to assist the evaporation of solvent. The portable cleaning device can also be utilized with other solvents supplied by the user.
Owner:MAH PAT Y

Backlight control system and method using dither sampling

A controller device provides for local and global control of illumination color and intensity of a backlight. The controller architecture allows for optimization of an illumination surface and simultaneous sensing, analysis and control of each supported region of the surface to enable uniform light and color luminance output from the surface. The controller utilizes a temporal feedback mechanism which allows the use of monochrome sensors to control the color luminance output of the illumination system. The controller can be used during production of displays to set initial optimal conditions and also to continuously monitor and adjust backlighting during use of the display by the consumer. By using high frequency monitoring and control signals, as well as color blending, testing and correction can be conducted during use and beyond the threshold of perception of the human observer.
Owner:X-RITE
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