The invention discloses a prostate disease ultrasonic treatment device, and particularly relates to the technical field of ultrasonic treatment, the prostate disease ultrasonic treatment device comprises a reinforcing support base, an ultrasonic treatment assembly is arranged at the top of the reinforcing support base, and a handheld treatment mechanism is arranged on the outer side of the ultrasonic treatment assembly and located at the top of the reinforcing support base. A reciprocating treatment mechanism is arranged on one side of the handheld treatment mechanism, the handheld treatment mechanism comprises a plurality of hydraulic supporting push rods arranged outside the ultrasonic treatment assembly, and reinforcing supporting plates are arranged at the tops of the hydraulic supporting push rods. Through cooperative use of all the structures, the device is suitable for different working environments, meanwhile, the device has good convenience and practicability during use, manual operation of workers is not needed, the labor intensity of medical workers is relieved, and the working efficiency is improved. Meanwhile, the ointment smeared on the second ultrasonic treatment probe has higher penetrability and pertinence during treatment, and the treatment effect of the device is improved.