The invention discloses a cleaning device of chemical plant equipment. The cleaning device comprises a base, a rolling support, a transverse plate and a baffle assembly; the structure design is reasonable, practicability is very high, during work, polluted equipment is firmly fixed to a rotating disc through a bandage, a water pump sprays water from a high-pressure nozzle through a water drawing pipe, a first motor drives the rotating disc to rotate through a rotating shaft, the polluted equipment can be subjected to comprehensive cleaning, the rolling support can effectively reduce friction force of the rotating disc, the service life is prolonged, the baffle assembly can effectively prevent sewage from being splashed, cleaning sewage water can enter a filter box through a sink and a sewer pipe, through a fine hole filter layer and an active carbon filter layer, sewage can be effectively purified, circular use is achieved, the device is more environment-friendly, saving is achieved, afan can rapidly dry the polluted equipment through a blowing head, the cleaning efficiency can be effectively improved, a second motor drives a transverse arm to move up and down through a screw anda sliding sleeve, the device can adapt to different sizes of the polluted equipment, and the use range is wider.