System and method to reducing risk of patient infections (HAI), using operating rooms equipped with suitable automatic airborne sterilizing agent generators, sensors, mechanisms, automatic air control devices, and ceiling mounted structures that allows the room to both provide air curtains of laminar flow sterilized air over the operating table, as well as to be quickly and completely sterilized. After suitable safety checks, the system isolates the interior air from external air, and activates an air phase anti-microbial agent generator, filing the room with air-phase anti-microbial agent. After sterilization, the invention deactivates the generator, removes the remaining air-phase anti-microbial agent by flowing room air through a catalytic converter, and then restores the connection to outside sterilized air. The ceiling mounted structure is configured for laminar flow air curtain delivery, supply lighting, and support boom mounted operating room equipment. Various sensors, control methods, wall coverings, and other options are disclosed.