The present invention relates to the screening of objects in-transit and materials, for security purposes (i.e. explosives detection).The invention provides an adjustable computerized system suitable for use at airports, seaports, land terminals, distribution centers, railway terminals, border crossings or other transit terminals, in order to achieve maximal efficiency and detection reliability, by adjustment of the screening process of any specific object to its risk factor in conjunction with the characteristics of the available in-line detection equipment.The invention provides an automated security inspection and conveying system for in-transit objects, comprising means for identifying the sender of each package and to profile and import the security status data relevant to the object into the system, and a plurality of various security screening machines in combination with conveying and sorting components. The system tracks each package from a reception point through the conveyors and screening machines to reach a sorting junction, via a user-adjustable screening process, the conveying and sorting components being interfaced with the security status data for assigning a risk assessment factor to the object and the sender. Each package is routed via an appropriate number of screening devices, the output of the screening devices being processed and the risk assessment factor being adjusted accordingly, the new risk assessment factor being sent to a control system of the conveying and sorting components.