Compositions for delivering peptide yy and pyy agonists

Abstract

The present invention provides a composition (e.g., a pharmaceutical composition) comprising at least one delivery agent compound and at least one of peptide YY (PYY) and a PYY agonist. Preferably, the composition includes a therapeutically effective amount of peptide YY or the PYY agonist and the delivery agent compound. The composition of the present invention facilitates the delivery of PYY, a PYY agonist, or a mixture thereof and increases its bioavailability compared to administration without the delivery agent compound. PPY and PYY agonists possess activity as agents to reduce nutrient availability, including reduction of food intake.

Description

[0001]This application claims the priority date of and incorporates by reference U.S. Provisional Patent Application No. 60 / 587,751, filed Jul. 12, 2004, and incorporates by reference U.S. patent application Ser. No. 10 / 846,954, filed May 14, 2004, U.S. Provisional Patent Application No. 60 / 470,905, filed May 14, 2003, U.S. Provisional Patent Application No. 60 / 471,114, filed May 15, 2003, U.S. Provisional Patent Application No. 60 / 506,702, filed Sep. 25, 2003, and U.S. Provisional Patent Application No. 60 / 536,697, filed Jan. 14, 2004.FIELD OF THE INVENTION[0002]The present invention relates to compositions for delivering peptide YY (PYY) and PYY agonists to a target. These composition include compounds that are well suited for forming non-covalent mixtures with PYY and PYY agonists for administration to animals. Methods for preparation, administration and treatment are also disclosed.BACKGROUND OF THE INVENTION[0003]Current antiobesity drugs have limited efficacy and numerous side...

AI Technical Summary

Benefits of technology

The present invention provides a composition that includes a delivery agent compound and peptide YY or a PYY agonist. This composition increases the bioavailability of peptide YY and its agonist compared to administration without the delivery agent compound. The composition can be administered to an animal through various methods, such as injection or buccal administration. The buccal administration method is preferred to minimize the formation of antibodies to the peptide YY or its agonist. The composition can also be used to improve the lipid profile in an animal or human by reducing food intake.

Problems solved by technology

Current antiobesity drugs have limited efficacy and numerous side effects.

The prospect of daily injections to control obesity is not very encouraging and may limit the use of these drugs.

Its oral activity, however, is negligible due to its low absorption and rapid degradation in the gastrointestinal tract.

These agents may be rapidly rendered ineffective or destroyed in the gastro-intestinal tract by acid hydrolysis, enzymes, and the like.

In addition, the size and structure of macromolecular drugs may prohibit absorption.

As a result, the oral administration of protein and peptide drugs is challenging due, in part, to their low absorption and rapid degradation.

However, broad spectrum use of such drug delivery systems is precluded in part because: (1) the systems require toxic amounts of adjuvants or inhibitors; (2) suitable low molecular weight cargos, i.e., active agents, are not available; (3) the systems exhibit poor stability and inadequate shelf life; (4) the systems are difficult to manufacture; (5) the systems fail to protect the active agent (cargo); (6) the systems adversely alter the active agent; or (7) the systems fail to allow or promote absorption of the active agent.

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