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Enhanced bioavailability of nutrients, pharmaceutical agents, and other bioactive substances through laser resonant homogenization or modification of molecular shape or crystalline form

a technology of laser resonant homogenization and enhanced bioavailability, which is applied in the direction of semiconductor lasers, applications, and therapy, can solve the problems of reducing the water content of the molecule, and achieve the effect of increasing the path width and minimizing the degradation of the

Inactive Publication Date: 2004-10-14
OVOKAITYS TODD F +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention is a method for modifying the structure of amino acids, phytonutrients, nutrient and food substances, pharmacologic agents, and other bioactive substances to improve their bioavailability and physiological response. The method involves using a laser to stimulate the molecule by resonance with specific frequencies, resulting in modifications that can be controlled by adjusting the laser amplitude and frequency. The laser stimulation can lead to the formation of new bonds, the promotion of certain configurations, or the inhibition of others. The method can be used in a variety of applications, such as crystallization, pharmaceutical formulation, and nutritional supplementation. The laser stimulation can also be used to modify the crystal structure of a molecule to improve its solubility or stability. The method is efficient, safe, and can be adjusted to target specific molecules or groups of molecules. Overall, the invention provides a novel and effective way to modify the structure and properties of bioactive substances for improved bioavailability and physiological response."

Problems solved by technology

This will have a tendency to "dry" the crystalline form in that it will tend to reduce the water content in the molecule.

Method used

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  • Enhanced bioavailability of nutrients, pharmaceutical agents, and other bioactive substances through laser resonant homogenization or modification of molecular shape or crystalline form
  • Enhanced bioavailability of nutrients, pharmaceutical agents, and other bioactive substances through laser resonant homogenization or modification of molecular shape or crystalline form
  • Enhanced bioavailability of nutrients, pharmaceutical agents, and other bioactive substances through laser resonant homogenization or modification of molecular shape or crystalline form

Examples

Experimental program
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Effect test

example 2

Production of Partially Amorphous Simvastatin through Application of Laser Acoustic Resonance

[0195] Two Samples of United States Pharmacopeia (USP) reference standard simvastatin of 21 mg each were used as an extension of the study described in Example 1. Each sample was dissolved in 200 mg of 100% ethanol and placed in a 10.times.35 mm polystyrene Petri dish. Sim 2A and Sim 2B were prepared for treatment with modulated sparse constructive node laser acoustic resonance to assess for differences in crystallinity using X-ray powder diffraction.

[0196] Both samples were crystallized by slow evaporation at room temperature. Sim 2A was treated with a 458 nm pumped argon gas laser of 2.1 mW primary power phase conjugated through the optical elements to a power level of 1.05 mW. The beam was modulated at 6.4 MHz and passed through the middle of the fluid meniscus of the solution until Sample 2A was fully crystallized. Sim 2B was treated with a Quantel Nd-YAG pulsed laser at 467 nm with an a...

example 3

Increased Arginine-Derived Nitric Oxide Production through Laser Treatment

[0202] The use of laser modification of compounds enhances the ability to modify not only the compound itself, but also by-products created by the body's use of the modified compound.

[0203] For example, four Samples of L-arginine (Arg) of 20 grams each, 3 for laser treatment and 1 an untreated control, were measured. Arg #1 was treated with a Quantel Nd-YAG pulsed laser at 532 nm with an average pulse amplitude of 2-5 mJ / pulse over 5 nanoseconds, 12 pulses per second. The optics were adjusted to maximum cancellation and the sample was treated for 30 seconds. Arg #2 was treated with a 458 nm pumped argon gas laser with a primary power of 16.5 mW adjusted through the optics to a power level of 5.06 mW. Arg #3 was treated with a 670 nm diode laser of 4.85 mW primary power adjusted through the optical elements to a power level of 2.94 mW. Arg #4 was the untreated control sample.

[0204] Paracelsian in Ithaca, N.Y., ...

example 4

Homogenization, Elongation, and Dehydration of L-arginine Hydrochloride through Laser Resonant Stimulation

[0209] In each of two 10.times.35 mm polystyrene Petri dishes 135 mg of L-arginine Hydrochloride were measured. Each sample was dissolved in 0.50 grams of deionized water. The control sample was crystallized by slow evaporation at room temperature over 24 hours. The average room temperature was approximately 26 degrees Centigrade. The average ambient humidity was approximately 33%.

[0210] The treated sample was crystallized under the same conditions with the addition of pulsed modulated energy at 532 nm as described for Arg #1 in Example 2 above. The beam was passed through the center of the meniscus of solution in the container.

[0211] Crystals from the control and treated samples were selected for further study. Selected crystals all had dimensions of approximately 0.5 mm on a side or less as per the latest standards in the art. The crystal structures were solved using a SMART X...

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Abstract

A method for improving the bioavailability of a bioactive substance includes subjecting the bioactive substance to laser radiation. The laser radiation modifies the bioactive substance to thereby modify reactions relating thereto in the body. The method enables reductions in inflammation associated with autoimmune diseases, modification of reaction by-products in the body, increased homogenization and flattening of molecular shape and improved methylation. The improved methylation can be utilized to reduce homocysteine blood levels, and to reduce anxiety, depression, paranoia, hostility, somatization (perception of bodily distress) and obsessive-compulsive symptoms. Enhanced nitric oxide generation from modified L-arginine can be used to reduce systolic and diastolic blood pressure, lower total and LDL cholesterol levels, and improve the ratio of total to HDL cholesterol. Increased depth of penetration of sparse constructive nodes of laser radiation may increase the range of photodynamic therapy applications and a wide range of in vitro and in vivo modifications of molecular shape and activity. Laser acoustic resonance can be utilized to increase the homogeneity of crystals, or favor the generation of novel or preferred crystalline forms.

Description

[0001] The present application is a continuation-in-part of U.S. application Ser. No. 10 / 069,052, which is the U.S. Nationalization of International Application No. PCT / GB00 / 03280, filed Aug. 29, 2000 which claims priority to GB 9920351.5, filed Aug. 28, 1999, and claims the benefit of U.S. Provisional Application No. 60 / 446,146, filed on Feb. 10, 2003, and U.S. Provisional Application No. 60 / 505,910, filed on Sep. 25, 2003.[0002] 1. Field of the Invention[0003] The present invention relates to novel dietary amino acid and nutrient products, as well as enhanced pharmaceutical products, and method for producing the same. More particularly, the present invention relates to such products and a method wherein the products have advantageously modified bioactivity reaction profiles and method for producing said products by means of exposure to specific amplitude modulated and structured laser light processes. These processes alter the bond structure and shape of molecules in the compound ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B19/00A61N5/00G01N21/39A61N5/06A61N5/067H01S5/062
CPCA61N5/00A61N2005/067A61N5/067
Inventor OVOKAITYS, TODD F.STRACHAN, JOHN SCOTT
Owner OVOKAITYS TODD F
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