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Multifunction antiseptic sterilizing cleaning agent composition and its preparation method

A disinfection and composition technology, applied in the direction of organic cleaning compositions, non-ionic surface active compounds, etc., can solve the problem of no long-term antibacterial effect, skin and mucous membrane irritation, bactericidal activity and stability of the composition, etc. problems, to achieve excellent dispersion and emulsification effects, enhanced bactericidal and antibacterial activity, unique bactericidal and long-lasting effects

Inactive Publication Date: 2006-06-14
雷金丰 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Glutaraldehyde has been used in the disinfection and sterilization of precision medical equipment for more than 40 years. It has a high level of disinfection and sterilization capabilities and is widely used in medical and other industries. It contributes to the health of the world It has made great contributions to the health cause, but people have also discovered its toxic and side effects during the long-term use process, such as the irritation to the human respiratory organs and eyes caused by its volatility, and the skin surface degeneration and dermatitis caused by direct contact. The occurrence of skin rashes, in addition, the instability of glutaraldehyde has also affected its further promotion and use to a certain extent. In recent years, o-phthalaldehyde has been introduced as a new high-level disinfectant at home and abroad. This disinfectant is volatile Relatively low, the irritation to human respiratory organs is also relatively low, but it is very irritating to the skin and mucous membranes, and it is easy to discolor the protein and cannot be in contact with the skin of animals, thus affecting its large-scale promotion use, in addition, the biodegradation of o-phthalaldehyde is relatively difficult, and it is easy to cause environmental pollution when discharged in the environment
[0003] At present, all kinds of endoscopes in hospitals are widely used and used more and more frequently. It is a precision instrument with a micro-camera, lighting and micro-surgical instrument system. It has a long lumen. It is mainly used in the human body. Working in the cavity of the human body, directly contacting human mucous membranes, blood and organs, it is very easy to be contaminated with various germs and viruses. If the disinfection is not thorough, it will cause cross-infection accidents and bring damage to people's health.
Due to the particularity of the material of the endoscope, it is highly sensitive to oxidizing and corrosive chemicals and high temperature operation, and its long lumen structure makes its cleaning and disinfection more difficult. For this reason, the US Patent "Process and composition for cleaning medical instruments comprising protease and quaternary ammonium disinfectant" (application number: 6762161 application date july13, 2004) has done a lot of attempts in these aspects, and obtained certain progress, this technology mainly adopts benzethonium chloride, benzethonium bromide Or other hydrocarbon-based quaternary ammonium salts, which have been formulated with other surfactants to make high-level disinfectants and more advanced hospital sterilizers, but there are many problems in it, such as 1. Poor impact on organic matter, instrument disinfection Or before sterilization, it must be soaked and rinsed with a special enzyme lotion before it can be soaked in a disinfection container; 2. There are many operating procedures and the cost of use is expensive; 3. The design of this system does not include human skin, hands and other aspects Disinfection function, there is no real long-term antibacterial effect, so it is limited in application
U.S. Patent "Receiving circuit, mobile terminal with receiving circuit, and method of receiving data" (application number: US768769, application date july27, 2004) then adopts benzethonium chloride, benzethonium bromide or other hydrocarbyl lamp quaternary ammonium salts, through and Fatty alcohol has been formulated into a high-level disinfectant, which can be applied to the disinfection of human skin and object surfaces. Since a relatively large amount of fatty alcohol must be used to achieve a synergistic effect, this use also brings strong irritation property, and due to the volatility of alcohol, the bactericidal activity and stability of the composition are greatly affected; in addition, the design of this combination only has a single main bactericidal component of benzethonium chloride or benzethonium bromide, resulting in product activity and Poor additional features
U.S. patent "Disinfectant composition" (application number: US6441045, application date August27, 2002), using the formula system of benzethonium chloride, achieves high-level disinfection capabilities (log value reduction ≥ 3), non-toxic, tasteless, and non-corrosive It can be applied to the food industry, human and animal bodies, surface of objects, and disinfection of hospital equipment, etc., but the level of sterilization cannot be achieved (the logarithmic value of spores is reduced by ≥ 5); and because the main bactericidal component of this system is only benzo Ammonium chloride, if there is no synergistic effect of other drugs, in fact the quick killing effect and long-term inhibitory effect on fungi and spores cannot be achieved; Strong solubility, easy to cause degreasing of human skin, especially long-term use can easily cause skin roughness, chapped and rashes; in addition, benzethonium chloride and benzethonium bromide compounds are difficult to degrade in the natural environment, and in actual use There will be many confusions and problems when

Method used

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  • Multifunction antiseptic sterilizing cleaning agent composition and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Weigh raw materials according to the following ratio:

[0059] Chloro-hydroxydiphenyl ether 0.1 kg;

[0060] 50 kg of dodecyl quaternary ammonium salt;

[0061] Chlorhexidine acetate 50 kg;

[0062] Polyphosphate 1 kg;

[0063] 300 kg of ethanol;

[0064] Malic acid 20 kg;

[0065] Fatty alcohol polyoxyethylene ether 200 kg;

[0066] spices 0.1 kg;

[0067] Pigment 0.01 kg;

[0068] 500 kg of deionized water.

[0069] First, put the chelating agent compound, quaternary ammonium salt compound, biguanide compound, fatty alcohol compound and non-ionic surfactant into the reaction kettle in sequence according to the formula amount, and add deionized water with one-third of the formula amount after stirring evenly. At the same time, start the heating device, and continue to stir for 30-60 minutes under the condition of 20°C-90°C; then add monochloro-hydroxydiphenyl ether into the above reaction solution, continue heating and stirring for 40-50 minutes, stop stirring ...

Embodiment 2

[0071] Weigh raw materials according to the following ratio:

[0072] 5 kg of dichloro-hydroxy diphenyl ether;

[0073] Hexaalkyl quaternary ammonium salt 0.1 kg;

[0074] Chlorhexidine gluconate 0.2 kg;

[0075] 25 kg of alkyl diamine tetraacetic acid;

[0076] 10 kg of isopropanol;

[0077] Tartaric acid 0.1 kg;

[0078] Cocamide 0.1 kg;

[0079] Spices 1 kg;

[0080] Pigment 0.1 kg

[0081] 300 kg of deionized water;

[0082] The preparation process is the same as in Example 1.

Embodiment 3

[0084] Weigh raw materials according to the following ratio:

[0085] Trichloro-hydroxyl diphenyl ether 10 kilograms;

[0086] 120 kg of octadecyl quaternary ammonium salt;

[0087] Polymethylbiguanide hydrochloride 25 kg;

[0088] Sodium alkyl diamine tetraacetate 50 kg;

[0089] Ethylene glycol 200 kg;

[0090] 30 kg of citric acid;

[0091] Polyalkylglucoside 150 kg;

[0092] Spices 10 kg;

[0093] Pigment 5 kg;

[0094] 700 kg of deionized water;

[0095] The preparation process is the same as in Example 1.

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Abstract

The invention relates to a multifunction disinfection sterilization detergent combination and the making method. It adopts quaternary ammonium salt, biguanide species, chelating agent, chlorine-hydroxyl diphenyl ether, fatty alcohol compound, organic acid compound, and nonionic reaction compound to make disinfection sterilization detergent. It is non-toxic and without side effect. So it can be widely used in various industries.

Description

technical field [0001] The invention relates to the field of detergent chemicals manufacturing, in particular to a multifunctional disinfection and sterilization detergent composition and a preparation method thereof. Background technique [0002] Glutaraldehyde has been used in the disinfection and sterilization of precision medical equipment for more than 40 years. It has a high level of disinfection and sterilization capabilities and is widely used in medical and other industries. It contributes to the health of the world It has made great contributions to the health cause, but people have also discovered its toxic and side effects during the long-term use process, such as the irritation to the human respiratory organs and eyes caused by its volatility, and the skin surface degeneration and dermatitis caused by direct contact. The occurrence of skin rashes, in addition, the instability of glutaraldehyde has also affected its further promotion and use to a certain extent. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11D1/66C11D3/30
Inventor 高旭雷金丰吴永东雷波
Owner 雷金丰
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