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Ginger phenols extract microcapsule and preparation method thereof

A technology of extract and gingerol, applied in the field of gingerol extract microcapsules and preparation thereof, can solve the problems such as the preparation of semi-liquid medicines, the volatile and deteriorating raw materials of gingerols extract, and the only oral use.

Inactive Publication Date: 2005-11-23
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are following defects in the preparation of gingerols extract into soft capsule dosage form: (1) gingerols extract raw material is volatile and rotten, so in the storage of raw materials, transportation and preparation production, must pay attention to the environment, prevent its rottenness and volatilization (2) The volume of the soft capsule is slightly larger and takes up a large space; (3) The soft capsule is easy to squeeze and break, which brings certain problems to transportation, storage, carrying and taking; (4) After the soft capsule is taken, it releases more oil and Gingerol extracts are irritating in the stomach; (5) can only be used orally
[0005] At present, there are no products or reports on the preparation of microcapsules from highly viscous semi-liquid drugs

Method used

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  • Ginger phenols extract microcapsule and preparation method thereof
  • Ginger phenols extract microcapsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Embodiment 1. Gingerols extract gelatin microcapsules

[0019] First prepare the gingerols extract. Take 50 kg of clean ginger slices, dry them, crush them, and put them in CO 2 In a supercritical extraction device, extraction is performed under suitable conditions to obtain a viscous semi-liquid extract of gingerols, wherein the weight ratio of total phenols accounts for more than 58%, and the weight ratio of 6-gingerol accounts for more than 16%.

[0020]Take 0.2g of gingerol extract and add 0.5g of corn oil to dissolve, then add 10ml of 10% gelatin, homogenate to form an emulsion, add 20ml of water to dilute, adjust the pH to 3.5 with 10% acetic acid solution, put it in a 50°C water bath and stir. Add 25ml of 30% sodium sulfate solution at 50°C dropwise to the stirred emulsion, stir for about 30min, then add 75ml of water at 50°C, then cool down to 15°C, add 100ml of 21.5% sodium sulfate solution at 15°C, and stir to produce A large number of flocs, add 2.5ml for...

Embodiment 2

[0023] Example 2. Gingerols Extract Hypromellose Phthalate Microcapsules

[0024] Take gingerol extract 0.2g and add ethanol 1ml to dissolve. Take 0.4g Na 2 HPO 4 .12H 2 Dissolve O in 10ml of water, add 0.5g of hypromellose phthalate (HP55), and stir to dissolve completely. Add 0.1g Tween 20 to the HP55 solution, then add the above ethanol solution of gingerols extract under stirring, stir into milk, add 6ml of 20% sodium sulfate solution, stir in a water bath, and gradually increase the temperature of the water bath to 50 °C, yellow flocs are produced, after stirring for 10 minutes, let stand for a while to precipitate the flocs, and pour out the supernatant. The remaining precipitate was washed three times with 30ml of 8.5% sodium sulfate solution (50°C), and 10ml of 5% acetic acid solution was added to the final precipitate and stirred for 10min to solidify the microcapsules, then washed three times with 30ml of dilute acetic acid solution, filtered, and washed with w...

Embodiment 3

[0028] Embodiment 3. Gingerols extract microcapsules

[0029] Prescription of Gingerol Extract Microcapsules

[0030] Ingredients Content

[0031] Gingerol Extract Gelatin Microcapsules 5g

[0032] Microcrystalline Cellulose 40g

[0033] Magnesium Stearate 1g

[0034] Preparation process: Take the gelatin microcapsules of gingerol extracts in Example 1 and mix them with microcrystalline cellulose, pass through a 30-mesh sieve and mix them evenly, then mix them evenly with talcum powder and magnesium stearate, and punch out tablets with 11mm, one side is smooth , the hardness is about 2-4kg, and each tablet contains about 50mg of gingerol extract gelatin microcapsules.

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Abstract

Disclosed is a ginger phenols extract microcapsule wherein the gingerol extract is bundled in a microcapsule, the microcapsule makes the semi-liquid state gingerol extract exist in the state of solid particles, and increases the constancy of the gingerol extract. The invention also provides the process for preparing the gingerol extract microcapsule.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a gingerol extract microcapsule and a preparation method thereof. Background technique [0002] Ginger is a traditional Chinese medicine in my country, and it is also a commonly used condiment in my country. It has the effects of relieving the exterior and dispelling cold, warming the middle and relieving vomiting, resolving phlegm and relieving cough. The medicinal components of ginger can be prepared by steam distillation or solvent extraction (including supercritical extraction) (Yu Zhen et al. Analysis of spicy components of ginger. Journal of Kunming Medical College, 2001, (4): 57-60; Wang Fasong et al. Molecular distillation purification and chemical composition analysis of ginger oil. China Pharmaceutical Industry Journal, 2003, 34(3): 125-127; Zhou Xiaodong. Supercritical CO 2 Research on the Extraction of Ginger Oil, the Characteristic Component of Ginger. Fine and Specialty ...

Claims

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Application Information

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IPC IPC(8): A61K31/12
Inventor 金义光李淼屠爱萍董俊兴张文明
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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