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Vitamin C oral disintegration tablet and its preparing method

A technology for orally disintegrating tablets and vitamins, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, antidote and other directions, can solve the problem of not finding the market of vitamin C orally disintegrating tablets or related reports, etc.

Active Publication Date: 2005-03-02
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Vitamin C currently has various dosage forms such as ordinary tablets, chewable tablets, effervescent tablets, dispersible tablets, buccal tablets, and injections, but no vitamin C orally disintegrating tablets have been listed or related reports have been found.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment one direct flavoring method

[0034] 1. Prescription

[0035] 1. Raw materials - vitamin C 250.0g;

[0036] 2. Adhesive - polyvinylpyrrolidone K-30 2.0g;

[0037] 3. Filling agent - mannitol 200.0g;

[0038] Microcrystalline cellulose 59.0g;

[0039] 4. Flavoring agent - aspartame 6.0g;

[0040] Orange essence 12.0g;

[0041] 5. Disintegrant—cross-linked polyvinylpyrrolidone 25.0g;

[0042] L-HPC 35.0g;

[0043] 6. Glidant—micronized silica gel 5.0g;

[0044] 7. Lubricant—magnesium stearate 6.0g.

[0045] The total weight is 600.0g, and a total of 1000 tablets are made, and the labeled tablet weight is 600mg / tablet.

[0046] 2. Preparation method

[0047] 1) Take the vitamin C raw material and pulverize it, granulate it with polyvinylpyrrolidone K-30, pass it through a 26-mesh sieve, and set aside;

[0048] 2) Pass the micronized silica gel, orange flavor and aspartame through a 40-mesh sieve respectively, mix we...

Embodiment 2

[0051] Embodiment two effervescent flavor correction method

[0052] 1. Prescription

[0053] 1. Raw materials - vitamin C 250.0g;

[0054] 2. Adhesive - polyvinylpyrrolidone K-30 4.0g;

[0055] 3. Filling agent - mannitol 163.0g;

[0056] 4. Effervescent agent - sodium bicarbonate 100.0g;

[0057] 5. Flavoring agent - aspartame 6.0g;

[0058] Orange essence 6.0g;

[0059] 6. Disintegrant—cross-linked polyvinylpyrrolidone 25.0g;

[0060] L-HPC 35.0g;

[0061] 7. Glidant—micronized silica gel 5.0g;

[0062] 8. Lubricant—magnesium stearate 6.0g.

[0063] The total weight is 600.0g, and a total of 1000 tablets are made, and the labeled tablet weight is 600mg / tablet.

[0064] 2. Preparation method

[0065] 1) The raw materials of vitamin C and sodium bicarbonate were pulverized respectively, and then respectively granulated with polyvinylpyrrolidone K-30, passed through a 26-mesh sieve, and set aside;

[0066] 2) Pass the micronized silica gel, o...

Embodiment 3

[0069] Example three powder coating taste masking method

[0070] 1. Prescription

[0071] 1. Raw materials - vitamin C 250.0g;

[0072] 2. Coating material - Eudragit  E100 25.0g;

[0073] 3. Filling agent - mannitol 237.0g;

[0074] 4. Flavoring agent - aspartame 6.0g;

[0075] Orange essence 6.0g;

[0076] 5. Disintegrant—cross-linked polyvinylpyrrolidone 35.0g;

[0077] L-HPC 25.0g;

[0078] 6. Glidant—micronized silica gel 10.0g;

[0079] 7. Lubricant—magnesium stearate 6.0g.

[0080] The total weight is 600.0g, and a total of 1000 tablets are made, and the labeled tablet weight is 600mg / tablet.

[0081] 2. Preparation method

[0082] 1) Take Eudragit  Dissolve E100 with more than 95% medical ethanol and dilute to a certain concentration for later use;

[0083] 2) Take vitamin C and place it in a fluidized bed to boil, spray the above solution at a certain speed for powder coating to obtain vitamin C powder coated granules, and dry th...

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Abstract

The present invention relates to one kind of orally disintegrated vitamin C tablet capable of disintegrating to release in oral cavity fast, and its preparation. The orally disintegrated vitamin C tablet is prepared with vitamin C as main material, and through adding stuffing, disintegrating agent, corrective, flow assistant and other supplementary material, pressing into tablet and other steps. The present invention has the features of low production cost, fast disintegration, good taste, clear chemical components, fast absorption, high bioavailability, etc.

Description

[technical field] [0001] The present invention relates to a vitamin C preparation that can be used for treating scurvy, anemia, allergic diseases, myocarditis, chronic hepatitis, Keshan disease, acute and chronic poisoning, etc., and especially relates to an orally disintegrating vitamin C with quick-release effect tablets. [Background technique] [0002] Vitamin C and dehydrovitamin C form a reversible redox system in the body, which plays an important role in biological oxidation and reduction and cellular respiration. Vitamin C is involved in the metabolism of amino acids, the synthesis of neurotransmitters, the synthesis of collagen and intercellular matrix. It can reduce the permeability of capillaries, accelerate blood coagulation, stimulate coagulation function, promote iron absorption in the intestine, promote blood lipid drop, increase resistance to infection, participate in detoxification function, and have antihistamine effect and prevent carcinogenesis Substanc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/375A61P1/16A61P7/00A61P39/02A61P43/00
Inventor 蒋海松王红喜王锦刚
Owner 北京科信聚润医药科技有限公司
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