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Active composition for repairing hard tissue and its prepn

A hard tissue and composition technology, applied in the field of medical surgical material preparation, can solve problems such as unfavorable bone synthesis, and achieve the effects of improving biodegradation and absorption function, accelerating bone healing, and promoting bone synthesis

Inactive Publication Date: 2003-03-19
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no indication in the literature that this material has a significant effect of inducing bone growth, which is unfavorable to bone synthesis and delays bone healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]Preparation of hard tissue repair materials: Absorbable synthetic polymer materials can be used in poly-L-lactic acid, poly-(D, L)-lactic acid, polyglycolic acid, polycaprolactone, polybutyrolactone, polyvalerolactone One or a copolymer of at least two of the following monomers: L-lactic acid, (D, L)-lactic acid, glycolic acid, caprolactone, butyrolactone, valerolactone, or their blends. For example, dissolve 0.8 g of poly-L-lactic acid in chloroform, disperse 0.2 g of unsintered hydroxyapatite with a particle size of about 1 micron in chloroform, mix the two, and slowly inject the above part of the mixture into Precipitate the composite material in cold ethanol, dry it in vacuum to remove the solvent, crush it properly to obtain a granular material with a particle size of about 1 mm, sterilize it with ethylene oxide, and mix it with 0.5 ml of dog bone marrow to obtain a hard tissue repair material.

Embodiment 2

[0036] Preparation of hard tissue repair materials: Dissolve 0.8 g of poly-L-lactic acid with a weight-average molecular weight of 150,000 in dioxane, and disperse 0.2 g of unsintered hydroxyapatite with a particle size of about 1 micron in dioxane , mix the two, and add an appropriate amount of gentamicin, inject the above mixture into the cavity—a cylindrical mold with a diameter of 15 mm and a height of 20 mm, freeze-dry at -70°C, and sterilize with ethylene oxide. Mix with 0.5ml of dog bone marrow to get hard tissue repair material.

Embodiment 3

[0038] Preparation of hard tissue repair materials: unsintered calcium phosphate salt can use low-temperature synthesized hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ), tricalcium phosphate (Ca 3 (PO 4 ) 2 ), calcium pyrophosphate (Ca 2 P 2 o 7 ), calcium hydrogen phosphate (CaHPO 4 ), calcium hydrogen phosphate dihydrate (CaHPO 4 .2H 2 O) one or a mixture of two or more calcium phosphate salts. For example, using unsintered tricalcium phosphate (Ca 3 (PO 4 ) 2 ). Dissolve 0.6 gram of poly L-lactic acid with a weight average molecular weight of 150,000 in dioxane, 0.2 gram of chitosan short fibers with a length of about 3 mm and 0.2 gram of unsintered chitosan fibers with a particle size of about 1 micron Tricalcium phosphate and 1 mg of bone morphoprotein were dispersed in dioxane, and the two were mixed evenly. Part of the above mixture was injected into the cavity—a cylindrical mold with a diameter of 15 mm and a height of 20 mm, freeze-dried at -70°C, sterilized...

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PUM

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Abstract

The present invention relates to surgical material. The material includes biological absorbable polymer 10-90 wt%, un-sintered calcium phosphate salt 9-80 wt% and active matter less than 50 wt%. The biologically absorbable polymer includes polyester, chitosan, chondroitin sulfate, collagen, alginate, etc.; and the calcium phosphate salt is un-sintered hydroxyapatite or tricalcium phosphate of granularity less than 100 microns. The hard tissue repairing material is prepared through mixing biologically absorbable polymer, un-sintered calcium phosphate salt, etc. dispersed in solvent, freeze drying to eliminate solvent and obtain porous material and mixing with active matter. The composition has the function of promoting bone healing and excellent biocompatibility.

Description

1. Technical field: [0001] The invention relates to an active composition for hard tissue repair and a preparation method thereof, and belongs to the technical field of preparation of materials for medical surgery. 2. Background technology: [0002] Hard tissues such as human bones and teeth are damaged due to disease or trauma, and artificial materials are required for repair or correction. Such repair materials include metals, inorganic materials, polymer materials, etc. [0003] Bone repair materials made of stainless steel or titanium alloy have high strength, low cost, and high frequency of use, but stress shielding may occur, which may lead to bone resorption, delay bone healing, and poor tissue compatibility. lead to inflammatory reactions, etc. [0004] Hydroxyapatite and tricalcium phosphate are commonly used bioceramics. Calcium phosphate bone cement is also commonly used in hard tissue repair. It has good biocompatibility. Hydroxyapatite can also induce osteogen...

Claims

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Application Information

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IPC IPC(8): A61L27/00A61L31/12
Inventor 李新松浦跃朴叶浪
Owner SOUTHEAST UNIV
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