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A kind of preparation method of voglibose capsule

A technology of voglibose and capsules, which is applied in the field of pharmaceutical preparations, can solve the problems of low dissolution rate, poor voglibose content uniformity, and poor voglibose content uniformity, and achieve uniformity Good, inhibition of crystallization, good dissolution and content uniformity

Active Publication Date: 2022-08-05
SHANDONG WEIFANG PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dispersible tablets and capsules obtained in this patent have low dissolution rate and poor voglibose content uniformity
[0007] As can be seen from the above, the current voglibose oral preparations still have problems such as low dissolution rate and poor content uniformity of voglibose

Method used

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  • A kind of preparation method of voglibose capsule
  • A kind of preparation method of voglibose capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation of a Voglilobacter Capsule capsule

[0033] Including the following steps:

[0034] 1. Preparation of the original medicinal solution

[0035] Add Fogllobo sugar to the exfoliating water, after dissolving completely, add twenty polyacin single-glycoglymine, polyethylene pyrigine, polyetterol 15-hydroxyl fatty lipate, oatsome β polysaccharide, stirring, stirring After the dissolution is complete, add microfanten silicone slowly, and after the feeding is fully stirred, the original drug solution is obtained;

[0036] The molecular weight of polyethylene pyrirol is 8800g / mol;

[0037] The molecular weight of polyethylene glycol 15-hydroxyl fatty acid ester is 963.2 g / mol;

[0038] The molecular weight of oat β glucan is 10530g / mol;

[0039] The particle size of the microfin silicone is 5 microns, and the surface area is 270M 2 / g;

[0040] The quality ratio of Fogleobo candy, ion water, twenty polyglycerin single-lipate, polyethylene pyrirol, polyetterol...

Embodiment 2

[0049] Example 2: Preparation of a Voglilobacter Capsule capsule

[0050] Including the following steps:

[0051] 1. Preparation of the original medicinal solution

[0052] Add Fogllobo sugar to the exfoliating water, after dissolving completely, add twenty polyacin single-glycoglymine, polyethylene pyrigine, polyetterol 15-hydroxyl fatty lipate, oatsome β polysaccharide, stirring, stirring After the dissolution is complete, add microfanten silicone slowly, and after the feeding is fully stirred, the original drug solution is obtained;

[0053] The molecular weight of polyethylene pyrirol is 6000g / mol;

[0054] The molecular weight of polyethylene glycol 15-hydroxyl fatty acid ester is 963.2 g / mol;

[0055] The molecular weight of oat β glucan is 6300g / mol;

[0056] The particle size of the microfin silicone is 3 microns, and the surface area is 150m than the surface area 2 / g;

[0057] The quality ratio of Fogleobo candy, ion water, twenty polyglycerin single-lipate, polyethylene...

Embodiment 3

[0066] Example 3: Preparation of a Voglipo Capsule capsule

[0067] Including the following steps:

[0068] 1. Preparation of the original medicinal solution

[0069] Add Fogllobo sugar to the exfoliating water, after dissolving completely, add twenty polyacin single-glycoglymine, polyethylene pyrigine, polyetterol 15-hydroxyl fatty lipate, oatsome β polysaccharide, stirring, stirring After the dissolution is complete, add microfanten silicone slowly, and after the feeding is fully stirred, the original drug solution is obtained;

[0070] The molecular weight of polyethylene pyrirol is 10000g / mol;

[0071] The molecular weight of polyethylene glycol 15-hydroxyl fatty acid ester is 963.2 g / mol;

[0072] The molecular weight of oat β glucan is 12000g / mol;

[0073] The particle size of the microfin silicone is 8 microns, and the surface area is 360M 2 / g;

[0074] The quality ratio of Fogleobo candy, ion water, twenty polyglycerin single-lipate, polyethylene pyrirol, polyetterol 15-h...

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Abstract

The invention discloses a preparation method of voglibose capsules, belonging to the field of pharmaceutical preparations, comprising five steps of preparation of original medicinal liquid, film drying, micronization, freeze drying and capsule filling. The invention prepares voglibose capsules with high dissolution rate and good uniformity of voglibose content, and the dissolution rates in 5 minutes, 15 minutes and 30 minutes are respectively 53.8-55.9%, 93.6-96.7% and 99.9%. ~100%, the voglibose content uniformity is 0.35~0.43; the present invention inhibits voglibose by adding polyvinylpyrrolidone and micropowder silica gel to the voglibose aqueous solution and cooperating with the rapid evaporation operation of coating film drying. The crystallization phenomenon during the precipitation process of boose yields voglibose in an amorphous powder state, so that the final capsule preparation has excellent dissolution and content uniformity.

Description

Technical field [0001] The present invention involves a preparation method of Fugulobo sugar capsule, which is the field of drug preparations. Background technique [0002] Fuglibang sugar is an α-glucosidase inhibitor. Its mechanism is that the maltase, isopacidase, glycosidase, etc. on the small intestinal mucosa, which reduces the decomposition of bisodium sugar to the monosaccharides, and causes D- The formation of glucose is reduced, thereby delaying the digestion and absorption of starch and sucrose, reducing blood glucose, and especially can control postprandial high blood sugar. Fugli sugar sugar hypoglycemic effect is smooth and does not stimulate the secretion of insulin. There is no high -blood glucose phenomenon in hypoglycemia without high insulinmia. [0003] As a hypoglycemic drug, Foglipo has a strict method of use, and it must be used before meals to effectively use it. [0004] To control the blood glucose level after meals, to achieve this purpose, Foglelobo mu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K31/133A61K47/32A61K47/04A61K47/14A61P3/10
CPCA61K31/133A61K9/4808A61K9/4866A61K9/485A61P3/10
Inventor 孙路路李金姑赵娜谭新孙园园周青青
Owner SHANDONG WEIFANG PHARMA FACTORY
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