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Bimetal-organic framework material as well as preparation method and application thereof

An organic framework and bimetal technology, applied in the field of nano-biomedical materials, can solve the problems of a single sensitization mode and the sensitization effect needs to be improved, and achieve the effects of improving recognition ability, promoting electron transfer effect, and improving stability

Active Publication Date: 2022-05-27
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing microwave ablation sensitizers mainly achieve ablation and sensitization of tumors by improving the thermal conversion efficiency of electromagnetic waves or stimulating active oxygen free radicals by microwaves. The sensitization mode is relatively single, and the sensitization effect still needs to be improved.

Method used

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  • Bimetal-organic framework material as well as preparation method and application thereof
  • Bimetal-organic framework material as well as preparation method and application thereof
  • Bimetal-organic framework material as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Accurately weigh 500 mg of aminoterephthalic acid, 100 microliters of ammonia water, 250 microliters of tetrabutyl titanate, and 12 mg of manganese chloride tetrahydrate, dissolved in 9 ml of N, N-dimethylformamide and 1 ml of methanol. In the mixed solution, sonicate for 30 minutes at room temperature. The solution was transferred to a high temperature reactor and reacted at 150°C for 12 hours. After the reaction, the samples were washed three times with N, N-dimethylformamide and methanol respectively, and the samples were dried to obtain Mn / Ti bimetal-organic framework materials.

[0045] The Mn / Ti bimetallic-organic framework material in this example is detected by transmission electron microscopy and elemental scans are as follows figure 1 , 2 As shown in the TEM image, the sample exhibits a rectangular two-dimensional nanosheet-like structure with a rough surface. As shown in the energy spectrum, the doped metal elements are uniformly distributed in the 2D meta...

Embodiment 2

[0047] Accurately weigh 300 mg of protoporphyrin, 50 μl of ammonia water, 100 mg of tetrabutyl titanate, and 5 mg of iron (III) nitrate nonahydrate, dissolved in 9 ml of N, N-dimethylformamide and 1 ml of methanol. In the mixed solution, ultrasonically dissolve for 45 minutes at room temperature. The solution was transferred to a high temperature reactor and reacted at 130°C for 8 hours. After the reaction, the samples were washed three times with N, N-dimethylformamide and methanol respectively, and the samples were dried to obtain Fe / Ti bimetallic-organic framework materials.

Embodiment 3

[0049] Accurately weigh 100 mg of succinic acid, 50 μl of ammonia water, 50 mg of ceric ammonium nitrate, and 10 mg of cobalt nitrate hexahydrate, dissolved in a mixed solution of 19 ml of N, N-dimethylformamide and 1 ml of methanol, and sonicated at room temperature. Solubilize for 30 minutes. The solution was transferred to a high temperature reactor and reacted at 150°C for 24 hours. After the reaction, the samples were washed three times with N, N-dimethylformamide and methanol respectively, and the samples were dried to obtain Co / Ce bimetallic-organic framework materials.

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Abstract

The invention belongs to the field of nano biomedical materials, and relates to a bimetallic-organic framework material as well as a preparation method and application thereof. The invention relates to a bimetallic-organic framework material, which is an X metal ion doped Y metal-organic framework material, and is of a nanosheet structure, the particle size length and width are 20-1000 nm, the thickness is 1-10 nm, the X metal and the Y metal comprise one or more of alkaline earth metal, main group metal and transition element metal, and the X metal and the Y metal are different metals. A spherical or three-dimensional metal-organic framework material before doping is converted into a nanosheet structure, the specific surface area and the surface activity are increased, doped metal ions can promote generation of reactive oxygen free radicals through electron gain and loss, the microwave excitation reactive oxygen free radical generation capacity is high, and the preparation method is simple and easy to implement. The microwave ablation effect of tumors can be enhanced, and medical imaging signals are improved. And the surface of the material is subjected to tumor targeted molecular modification and drug loading, so that the tumor microwave treatment effect can be improved.

Description

technical field [0001] The invention belongs to the field of nanometer biomedical materials, and relates to a metal-organic framework material, in particular to a bimetal-organic framework material and a preparation method and application thereof. Background technique [0002] Microwave interventional therapy is one of the commonly used clinical tumor treatment methods. The main principle is that the microwave magnetic field released by the microwave needle punctured into the lesion causes the surrounding polar molecules to rotate at high speed to generate heat, thereby causing coagulation necrosis of cancer tissue. , to achieve the purpose of tumor treatment. Microwave ablation has the advantages of minimally invasive, safe, and short treatment time, and is widely used in the treatment of solid tumors such as liver cancer, lung cancer, prostate cancer, breast cancer, etc. However, due to the high power, high temperature and the limitation of the imaging instrument to accur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00A61K41/00A61K47/69A61K47/60A61K47/62A61K45/00A61P35/00A61K49/06B82Y5/00B82Y40/00
CPCC08G83/008A61K41/0057A61K47/6949A61K47/60A61K47/62A61K45/00A61P35/00A61K49/06B82Y5/00B82Y40/00
Inventor 任文智覃琼玉吴爱国杨明
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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