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Quality detection method of patchouli oil, clathrate compound of patchouli oil, dry suspension and application of clathrate compound and dry suspension

A quality inspection method, the technology of patchouli oil, is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, drug combinations, etc., to improve drug bioavailability and stability, high in vivo safety, The effect of increasing solubility

Pending Publication Date: 2021-10-22
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the simple preparation method of dry suspension, it is suitable for industrial production, it is beneficial to drug solubilization, it improves the uniformity of drug content, it has the characteristics of large distribution area in the gastrointestinal tract, fast absorption and high bioavailability, and it is suitable for solving insoluble drug delivery. Therefore, it is suitable for the development of formulations of drugs such as volatile oils. At present, there is no research report on making patchouli oil into a dry suspension

Method used

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  • Quality detection method of patchouli oil, clathrate compound of patchouli oil, dry suspension and application of clathrate compound and dry suspension
  • Quality detection method of patchouli oil, clathrate compound of patchouli oil, dry suspension and application of clathrate compound and dry suspension
  • Quality detection method of patchouli oil, clathrate compound of patchouli oil, dry suspension and application of clathrate compound and dry suspension

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Experimental program
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Effect test

preparation example Construction

[0092] (1) Preparation of reference substance solution: take 1-2 mg of commercially available patchouli alcohol and patchouli ketone reference substances, add n-hexane to dissolve respectively;

[0093] (2) Preparation of the test solution: pipette 50 μL of the commercially available sample, respectively add 200 μL of n-hexane, shake well to obtain the test solution;

[0094] (3) Chromatographic conditions:

[0095] Chromatographic column: Agilent HP-5MS, 30m×0.25mm×0.25μm (serial number USN398724H); temperature program: 70°C at 3°C / min to 150°C, then at 2°C / min to 170°C, then at 5°C ℃ / min increased to 230°C and held for 11min; detector: MS; inlet temperature: 230°C; detector temperature: 250°C; carrier gas: He; column flow rate: 1mL / min; injection volume: 1μL; Ratio: 50:1; Scan type: SCAN; SCAN mode molecular weight range: 50-550.

[0096] (4) Analytical method: use GC-MS technology to measure, analyze the chromatographic and mass spectrum information of the reference subst...

Embodiment 1

[0253] A construction method of patchouli oil GC-MS characteristic spectrum:

[0254] (1) Preparation of reference substance solution: take 1-2 mg of patchouli alcohol and patchouli ketone reference substances, add n-hexane to dissolve them respectively.

[0255] (2) Preparation of the test solution: pipette 50 μL of the commercially available sample, respectively add 200 μL of n-hexane, shake well to obtain the test solution.

[0256] (3) The detection conditions of chromatography and mass spectrometry are shown in Table 9:

[0257] Table 9. GC-MS chromatography and mass spectrometry conditions

[0258]

[0259]

[0260] (4) Analysis and determination: draw 1 μL of the test solution and inject it into the gas chromatography-mass spectrometer for GC-MS detection, analyze the chromatographic and mass spectrometry information of the reference solution and the test solution, and match with the GC-MS NIST database The qualitative attribution information of the 13 character...

Embodiment 2

[0266] Detection of GC-FID fingerprint of patchouli oil:

[0267] (1) Preparation of internal standard solution and reference substance solution: accurately weigh 142.24mg of n-octadecane into a volumetric flask, add n-hexane to make the volume to 10mL, shake well, and set aside; accurately weigh 6.399mg of patchouli alcohol reference substance To the volumetric flask, accurately add 0.2mL internal standard solution, and dilute to 2mL with n-hexane; accurately weigh 4.736mg of patchouli ketone reference substance into the volumetric flask, accurately add 0.2mL internal standard solution, and dilute to volume with n-hexane to 2 mL.

[0268] (2) Preparation of the test solution: pipette 50 μL of a commercially available sample, add 200 μL of n-hexane respectively, and shake well to obtain the test solution.

[0269] (3) Chromatographic conditions are shown in Table 11:

[0270] Table 11. Chromatographic conditions determined by GC-FID method

[0271]

[0272] (4) Analysis ...

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Abstract

The invention relates to a quality detection method of patchouli oil, clathrate compound of patchouli oil, dry suspension and pharmaceutical application of the clathrate compound anddry suspension. The quality detection method of the patchouli oil comprises the following steps o: S1, measuring the spectrum of the patchouli oil by using GC-MS; S2, matching the spectrum in the step S1 according to a GC-MS NIST database to obtain qualitative affiliation information of characteristic peaks; and S3, according to the spectrum in the step S1 and the qualitative affiliation information in the step S2, detecting the peak areas corresponding to actin, delta-guaiacol, patchouli alcohol and patchouli ketone in the spectrum in the step S1, and if the ratio of the sum of the peak areas is greater than 70%, indicating that the patchouli oil is qualified. According to the quality detection method of the patchouli oil, the quality of traditional Chinese medicine can be rapidly detected, traditional Chinese medicine standards are standardized, pharmacological research of traditional Chinese medicine is promoted, and a safe, reliable and convenient-to-store traditional Chinese medicine preparation is provided.

Description

technical field [0001] The present invention relates to the quality detection method of patchouli oil, its medicinal dosage form and its use; Use in the preparation of a medicament for treating ulcerative colitis. Background technique [0002] Ulcerative colitis is a complex disease involving immune response, changes in colon structure and intestinal flora. It has the characteristics of long course, difficult to cure and easy to relapse. It can be life-threatening after the disease worsens. In addition, it will increase the risk of colorectal cancer for patients , known as "cancer that is not cancer". At present, the drug treatment of this disease is mainly based on aminosalicylic acid, glucocorticoid or immunosuppressant. However, the long-term treatment effect is not good, and long-term use of such drugs has great side effects. Therefore there is no reliable drug effect, good safety, suitable for long-term or life-long use of therapeutic drugs. [0003] Ulcerative coli...

Claims

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Application Information

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IPC IPC(8): G01N30/86A61K36/532A61K9/10A61K47/26A61K47/36A61K47/69A61P1/00A61P1/04
CPCG01N30/8634G01N30/8686A61K36/532A61K9/10A61K47/26A61K47/36A61K47/6951A61P1/00A61P1/04
Inventor 黄永焯王冰刘团兵
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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