Degradable polymer capable of being used for wound dressing, preparation method of degradable polymer, and wound dressing

Abstract

The invention belongs to the technical field of polymer synthesis, and particularly relates to a degradable polymer for wound dressing. The degradable polymer is a block polymer comprising a PLGA (polylactic-co-glycolic acid) chain segment and a poly-aliphatic diol chain segment. The wound dressing has the beneficial effects that the wound dressing can easily coat the surfaces of skin tissues and various materials, is excellent in filling property and fitting property, and does not fall off under the condition that wound exudate appears; the wound dressing has good biocompatibility and presents biodegradability; the produced wound dressing is in a transparent state, and the transparent state is beneficial to real-time wound examination, so treatment delay is avoided; the wound dressing has certain water absorption performance, so a moist environment of the wound is kept, and wound repairing is facilitated; and the polymer is simple in reaction process, short in reaction time and easy to prepare and preserve in a large scale.

Description

technical field [0001] The invention belongs to the technical field of polymer synthesis, and relates to a degradable polymer that can be used in wound dressings, a preparation method thereof, and wound dressings. Background technique [0002] As the largest organ of the human body, the skin is the first barrier against external invasion. Skin wounds caused by trauma, burns or diseases can be divided into acute wounds and chronic wounds according to the speed of healing, and can be divided into superficial wounds, partial layer wounds and comprehensive wounds according to the damaged cortex. Some wounds have a certain self-healing ability, and self-repair can be completed through the hemostasis and inflammatory response phase, the proliferation phase, and the tissue reconstruction phase. But some wounds are difficult to heal once infected, which can lead to fatal diseases such as sepsis. Therefore, the application of wound dressings to protect and provide a clean and good ...

AI Technical Summary

Problems solved by technology

[0004] However, existing medical adhesives still have certain problems and cannot fully meet the requirements. For example, although cyanoacrylate adhesives have high bonding strength, they have certain cytotoxicity and are not compatible with wet surfaces. Immediately solidified after water to form a hard phase area, which cannot meet the needs of dynamic sports; although fibrin adhesives have good biocompatibility, they have weak adhesion to tissues; foam dressings or hydrogel dressings, due to self-adhesive Due to factors such as poor binding ability and rapid water loss, most of them need to be removed twice to avoid residues in the body; commonly used processes such as chemical cross-linking, physical cross-linking and electron radiation cross-linking may have cross-linking agent residues and poor stability Risks such as incomplete polymerization of toxic monomers

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