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Photosensitive material, preparation method and application of photosensitive material in tumor photothermal combined immunotherapy

A technology of photosensitive material and photosensitizer, applied in the field of biomedicine

Active Publication Date: 2021-09-07
SHENZHEN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] As can be seen from the above, both immunotherapy and photothermal therapy have certain medical limitations

Method used

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  • Photosensitive material, preparation method and application of photosensitive material in tumor photothermal combined immunotherapy
  • Photosensitive material, preparation method and application of photosensitive material in tumor photothermal combined immunotherapy
  • Photosensitive material, preparation method and application of photosensitive material in tumor photothermal combined immunotherapy

Examples

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preparation example 1

[0059] This preparation example prepares Cr nanoparticles:

[0060] Mix 100 mg of Cr powder with 100 mL of IPA (isopropanol), place the mixture in ice water, perform ultrasonic treatment of the probe (8h, 200W), set the on / off cycle of 2 / 2s for the ultrasonic treatment of the probe, and obtain a suspension; The suspension was subjected to water-bath ultrasonication (10h, 360W, water temperature 10°C). After two ultrasonic treatments, the prepared dispersion was centrifuged at a speed of 1000g for 30min to remove larger Cr particles; The supernatant was poured out gently, and centrifuged at a speed of 8000 g for 30 min to obtain Cr nanoparticles. The Cr nanoparticles were dried in a vacuum oven, packed in tin foil, and stored at 4°C.

preparation example 2

[0062] This preparation example prepares the material of polydopamine-loaded Cr nanoparticles (subsequently represented by DA@Cr):

[0063] Mix dopamine hydrochloride and Cr nanoparticles in water at a mass ratio of 2:1, add 1% NaOH by mass fraction, and stir for 12 hours at 25°C in the dark to obtain DA@Cr.

preparation example 3

[0065] This preparation example prepares polydopamine-loaded Cr nanoparticles and BMS-202 materials (subsequently represented by DA@Cr-BMS-202):

[0066] Disperse DA@Cr in the organic solvent IPA at 1 mg / mL, and dissolve BMS-202 in DMSO at 10 mg / mL; mix the DA@Cr dispersion with the BMS-202 solution at a mass ratio of 2:1, at 25 °C Stir in the dark for 12 hours, wash with PBS 3 times to obtain DA@Cr-BMS-202.

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Abstract

The invention relates to a photosensitive material, a preparation method and application of the photosensitive material in tumor photothermal combined immunotherapy. The photosensitive material comprises polydopamine and photosensitizer chromium nanoparticles loaded by the polydopamine through electrostatic adsorption. The invention further relates to a drug delivery system, a preparation method and application of the drug delivery system. The drug delivery system comprises the polydopamine, the photosensitizer chromium nanoparticles loaded by the polydopamine through electrostatic adsorption and an immunostimulation drug BMS-202. The drug delivery system combines photothermal therapy and immunotherapy, perfectly overcomes the defects of the single photothermal therapy and the single immunotherapy, and has good biological safety and passive tumor tissue targeting ability. Under irradiation stimulation of infrared NIR, the ability of killing tumor cells by light and heat is achieved; and meanwhile, the BMS-202 drug released by light control can effectively inhibit PD-1 / L1 related pathways, the released Cr material promotes proliferation and activity of macrophages, and a good anti-tumor microenvironment is created for tumor immunotherapy.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, relates to a photosensitive material and its preparation method and its application in combined photothermal immunotherapy for tumors, in particular to a photosensitive material and its preparation method, a drug delivery system containing it and its application Preparation methods and applications. Background technique [0002] With the continuous intersection and infiltration development of oncology, molecular biology and immunology, tumor immunotherapy technology has been developed by leaps and bounds and has become a new direction for tumor treatment. With the continuous breakthroughs in basic research and clinical application of tumor immunotherapy, immunotherapy has become the fourth major tumor treatment method after surgery, radiotherapy, and chemotherapy, and has made remarkable achievements. Tumor immunotherapy is a treatment method that passively or actively mobilizes the body's i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/59A61K31/44A61K9/00A61P35/00A61P37/04
CPCA61K47/59A61K41/0057A61P35/00A61P37/04A61K31/44A61K9/0009A61K41/0042A61K2300/00
Inventor 刘利平刘权孙哲吕孔鹏张强弩石露林鲍世韵
Owner SHENZHEN PEOPLES HOSPITAL
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