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Three-dimensional reticular chitosan slow-release coating and preparation method thereof

A three-dimensional mesh, chitosan technology, used in coatings, prostheses, medical sciences, etc., can solve the problems of low bonding strength of hydrogel coatings and base materials, unable to adhere firmly, and achieve easy chemical The effect of modification, high production efficiency and simple experimental process

Active Publication Date: 2021-08-06
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bonding strength between the hydrogel coating and the base material prepared by traditional methods such as electrochemical deposition and layer-by-layer self-assembly is low, and it cannot firmly adhere to the surface of complex-shaped materials.

Method used

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  • Three-dimensional reticular chitosan slow-release coating and preparation method thereof
  • Three-dimensional reticular chitosan slow-release coating and preparation method thereof
  • Three-dimensional reticular chitosan slow-release coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Dissolve 1 g of chitosan powder in 100 ml of 1% (v / v) acetic acid solution to obtain a 1% (w / v) chitosan solution, and add it dropwise at a constant speed to the prepared chitosan solution Methacrylic anhydride (the ratio of acid anhydride to amino group is 2:1), keep the whole reaction system stirring at a constant speed from the beginning to the end, and heat the reaction in a water bath at 60°C for 12 h, and adjust the reacted solution to neutral with sodium bicarbonate pH for standby, put the chitosan derivative solution prepared above into a dialysis bag and dialyze in deionized water for 4 to 5 days to remove unreacted substances, add 0.2 wt% I2959 light to the CSMA prepolymerization solution Initiator and appropriate amount of 4 MCaCl 2 The solution was mixed with a magnetic stirrer, and then irradiated with low-dose ultraviolet light for 10 min to successfully construct the CSMA hydrogel coating.

Embodiment 2

[0031] Dissolve 1g of chitosan powder in 100 ml of 1% (v / v) acetic acid solution to obtain a 1% (w / v) chitosan solution, and add formazan dropwise to the prepared chitosan solution at a constant speed base acrylic anhydride (the ratio of acid anhydride to amino group is 2:1), keep the whole reaction system stirring at a constant speed from the beginning to the end, and heat the reaction in a water bath at 60°C for 12 h, and adjust the reacted solution to neutral pH with sodium bicarbonate Standby, put the chitosan derivative solution prepared above into a dialysis bag and dialyze in deionized water for 4 to 5 days to remove unreacted substances, heat and concentrate to one-third of the original volume, Adding 0.2wt% I2959 photoinitiator to the pre-polymerization solution, mixing with a magnetic stirrer, and then irradiating with low-dose ultraviolet light for 10 min, the CSMA hydrogel coating can be successfully constructed.

Embodiment 3

[0033] Dissolve 1g of chitosan powder in 100 ml of 1% (v / v) acetic acid solution to obtain a 1% (w / v) chitosan solution, and add formazan dropwise to the prepared chitosan solution at a constant speed base acrylic anhydride (the ratio of acid anhydride to amino group is 2:1), keep the whole reaction system stirring at a constant speed from the beginning to the end, and heat the reaction in a water bath at 60°C for 12 h, and adjust the reacted solution to neutral pH with sodium bicarbonate Standby, put the chitosan derivative solution prepared above into a dialysis bag and dialyze in deionized water for 4 to 5 days to remove unreacted substances, add 0.2 wt% I2959 photoinitiated to the CSMA prepolymerization solution agent with appropriate amount of 4 MCaCl 2 The solution was mixed with a magnetic stirrer, and then irradiated with low-dose ultraviolet light for 10 min. The hydrogel coating was put into a special device containing ammonium carbonate for mineralization. CSMA / CaC...

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Abstract

The invention discloses a preparation method of a chitosan-methacrylic anhydride / calcium carbonate (CSMA / CaCO3) hydrogel slow-release coating. The surface of the coating is of a porous net structure. The preparation method comprises the following steps: (1) preparing a chitosan solution dissolved in dilute acetic acid; (2) adding methacrylic anhydride (MA) into the chitosan solution obtained in the step (1), and grafting methacrylic anhydride on chitosan through a hydrothermal method under a high-temperature condition to prepare chitosan-methacrylic anhydride (CSMA); (3) performing neutralizing, and dialyzing the chitosan-methacrylic anhydride obtained in step (2); (4) adding a photoinitiator I2959 and a calcium chloride solution into the solution obtained in the step (3), and performing ultraviolet irradiation crosslinking to obtain slow-release hydrogel; and 5) introducing ammonium carbonate into the hydrogel obtained in the step (4) to prepare the glycan-methacrylic anhydride / calcium carbonate hydrogel slow-release coating. The method is simple in preparation process, mild and controllable in condition, good in repeatability, low in production cost and suitable for industrial production. The prepared porous network hydrogel sustained-release coating has the advantages of good biocompatibility, easiness in degradation, high load rate and the like, and has wide application prospects in the fields of medicine and chemical industry.

Description

technical field [0001] The invention belongs to the technical preparation field of biological materials, and in particular relates to a three-dimensional reticular chitosan slow-release coating and a preparation method thereof. Background technique [0002] As a coating on titanium materials, hydrogel has the characteristics of good biocompatibility and in-situ injection molding. The soft and wet properties of the hydrogel also possess low friction, so it can be used as artificial cartilage in total joint prosthesis, and it is also shown to be suitable for cell adhesion proliferation and differentiation. The three-dimensional porous structure of hydrogel can imitate the structure of extracellular matrix, and implantation in vivo is conducive to material transportation and cell growth in vivo. On the other hand, these hydrogel coatings improve the biocompatibility of titanium and can carry antibiotic drugs in situ, which can be used for drug delivery and reduce their immunog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/44A61L27/52A61L27/54A61L27/56C08B37/08
CPCA61L27/34A61L27/52A61L27/56A61L27/54A61L27/446C08B37/003A61L2300/236A61L2300/404A61L2300/802A61L2300/10C08L5/08
Inventor 陈岑杨家赵周昌顺解纯刚刘帆
Owner ZHEJIANG SCI-TECH UNIV
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