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Probiotic tablet capable of controlling weight and preparation method of probiotic tablet

A technology of probiotic tablets and mutants, applied in the direction of biochemical equipment and methods, microorganism-based methods, bacteria used in food preparation, etc., can solve the problem of butyrate reduction, decreased intestinal barrier integrity, and increased mucus degradation and oxidative stress, to reduce fat vacuoles, lower serum leptin levels, and promote proliferation of spleen lymphocytes

Active Publication Date: 2021-04-02
HANGZHOU WAHAHA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Alterations in these flora result in reduced butyrate production, which in turn reduces gut barrier integrity, increases mucus degradation, and oxidative stress

Method used

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  • Probiotic tablet capable of controlling weight and preparation method of probiotic tablet
  • Probiotic tablet capable of controlling weight and preparation method of probiotic tablet
  • Probiotic tablet capable of controlling weight and preparation method of probiotic tablet

Examples

Experimental program
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Effect test

preparation example Construction

[0092] The preparation method of described plantarum lactobacillus freeze-dried powder comprises the following steps:

[0093] 1) Preparation of medium: the medium is an improved MRS medium, and its formula is glucose 20-30g, beef extract 10-13g, tryptone 5-7g, soybean peptone 5-7g, yeast powder 5-6g, acetic acid Sodium 3-5g, diammonium hydrogen citrate 1-2g, dipotassium hydrogen phosphate 2-3g, magnesium sulfate 0.4-0.6g, cysteine ​​hydrochloride 0.4-0.7g, Tween-80 1-2mL, Manganese sulfate hydrate 0.2-0.25g, water 1000mL; adjust its pH to 6.5±0.2;

[0094] 2) Preparation of bacterial strain protective agent: the formula of the bacterial strain protective agent is skim milk 80g / L, trehalose 100g / L, glycerin 20g / L;

[0095] 3) Inoculate Lactobacillus plantarum and / or its mutants in the fermentation substrate with 5%-10% inoculation amount to carry out fermentation culture, the fermentation temperature is 34-38°C, the fermentation time is 13-18h, and the pH of the fermentation ...

Embodiment 1

[0109] Embodiment 1: Optimization of high-density fermentation process

[0110] After the second-generation activation of Lactobacillus fermentum WHH3906 and Lactobacillus plantarum 1701 of the present invention, they were inoculated in a fermenter containing 5L of MRS medium at a 2% inoculation amount, and the culture conditions were: 37°C, 150rpm, pH5.5 or no pH control , continuous culture for 16h. Take the 16h bacterial liquid, and measure the number of viable bacteria by the dilution smear counting method. Preparation of medium: the formula of the MRS medium is glucose 20g, beef extract 13g, tryptone 5g, soybean peptone 7g, yeast powder 6g, sodium acetate 3g, diammonium hydrogen citrate 1g, dipotassium hydrogen phosphate 3g, sulfuric acid Magnesium 0.6g, cysteine ​​hydrochloride 0.4g, Tween-80 1mL, manganese sulfate monohydrate 0.2g, water 1000mL; adjust its pH to 6.5.

[0111] It can be seen from Table 1 that when the pH of the fermentation process was not controlled f...

Embodiment 2

[0114] Example 2: Probiotic Tablets for Weight Control

[0115] A probiotic tablet for weight control, including 10 parts of Lactobacillus fermentum freeze-dried powder, 10 parts of Lactobacillus plantarum freeze-dried powder, 5 parts of white kidney bean extract, 5 parts of green coffee bean extract, 5 parts of blueberry powder, 5 parts of ginger powder, 20 parts of inulin, 20 parts of erythritol, 18.95 parts of direct-pressed excipients, 0.05 parts of vitamin C and 1 part of magnesium stearate. The number of live bacteria in the freeze-dried powder of Lactobacillus plantarum is 3×10 9 CFU / g. The direct-compression auxiliary material is direct-compression maltitol.

[0116] The preparation method of described plantarum lactobacillus freeze-dried powder comprises the following steps:

[0117] 1) The preparation of medium, described medium, is the improved MRS medium, and its formula is glucose 20g, beef extract 13g, tryptone 5g, soybean peptone 7g, yeast powder 6g, sodium a...

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Abstract

The invention relates to the field of food, and discloses a probiotic tablet capable of controlling weight and a preparation method of the probiotic tablet. The probiotic tablet is prepared from lactobacillus fermentum freeze-dried powder, lactobacillus plantarum freeze-dried powder, a white kidney bean extract, a green coffee bean extract, blueberry powder, fresh ginger powder, inulin, erythritol, a direct pressure type auxiliary material, vitamin C and magnesium stearate, wherein the lactobacillus fermentum is named as WHH3906, and the lactobacillus plantarum is named as 1701. In the probiotic tablet disclosed by the invention, the lactobacillus plantarum 1701 and the lactobacillus fermentum WHH3906 have a synergistic effect, so that a relatively good lipid-lowering and weight-losing effect can be achieved after compounding; the blueberry powder and the fresh ginger powder can relieve chronic inflammation and reduce pathogenic bacteria in intestinal tracts, and growth and field planting of the lactobacillus plantarum and the lactobacillus fermentum are facilitated; and inulin and erythritol can be used as energy substances of the lactobacillus plantarum and the lactobacillus fermentum to promote the growth of the the lactobacillus plantarum and the lactobacillus fermentum, so that the lactobacillus can play a role in controlling the weight.

Description

technical field [0001] The invention relates to the field of food, in particular to a weight-controlling probiotic tablet and a preparation method thereof. Background technique [0002] Obesity is a global public health problem. According to statistics from the World Health Organization in 2016, more than 1.9 billion adults worldwide are facing obesity problems. Obesity is mainly manifested as abnormal or excessive accumulation of body fat, which can lead to a series of related complications and threaten people's health. Obesity is mainly affected by multiple factors such as genetics, living and eating habits, environment and social relations, emotion and psychological cognition, physiology and metabolism, etc., and is related to many chronic metabolic diseases, such as hypertension, dyslipidemia, insulin resistance, II Type 2 diabetes, coronary heart disease, etc. As a chronic metabolic disease, obesity affects people's health in many ways, and can also lead to the develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23L33/105A23L33/10A23L33/21A23L33/125C12N1/20C12R1/25C12R1/225
CPCA23L33/135A23L33/105A23L33/10A23L33/21A23L33/125C12N1/20A23V2002/00A23V2400/143A23V2400/169A23V2200/332A23V2200/3262A23V2200/326A23V2200/32A23V2250/21A23V2250/2108A23V2250/5062A23V2250/6402A23V2250/708A23V2250/6416A23V2250/642Y02A50/30
Inventor 孙盛俞赟霞陈苏任学良葛红娟李言郡余腾斐陈作国陈丽娥陈彩玲郑志瑶周晴晴
Owner HANGZHOU WAHAHA TECH
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