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Application of isoquinoline compound to preparation of antiviral product

A compound, isoquinoline technology, used in the production of antiviral agents, bulk chemicals, and resistance to vector-borne diseases, etc., can solve the problems of complex mechanism of action, different ways of invading cells, and unclear antiviral mechanism.

Active Publication Date: 2021-03-19
GENIFARM LAB INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is also reported that isoquinoline alkaloids are used for antiviral infection, such as CN201510942635.8, which reports that the isoquinoline alkaloids isolated from the bark of the Dai nationality medicinal plant Leguminosae cassia (Cassia alata L.) have the effect on rotavirus Good inhibitory effect; CN201710256643.6 reports the activity of isoquinoline alkaloids on hepatitis B virus and is used for the treatment of hepatitis B; CN201110218079.1 reports the activity of isoquinoline alkaloids on human papillomavirus; CN200910063163.3 reports the activity of berberine against influenza Virus activity, etc., but due to the variety of viruses, complex mechanism of action, and different ways of invading cells, the number of studies is small, and the mechanism of anti-virus is still unclear
Typically, antimicrobials have no effect on viral infections and are not used as antiviral products

Method used

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  • Application of isoquinoline compound to preparation of antiviral product
  • Application of isoquinoline compound to preparation of antiviral product
  • Application of isoquinoline compound to preparation of antiviral product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] The effect of embodiment 1 grand new to the pig that has been infected with African swine fever virus

[0067] 1. Experimental pigs: Located in a farm in Henan Province where an African swine fever epidemic occurred, selected nursery pigs that had no clinical symptoms and were confirmed positive for African swine fever virus by saliva sampling and PCR. Pigs with clinical symptoms were all culled and treated harmlessly. Take biosafety measures in the whole process.

[0068] 2. Grouping: The experimental pigs were randomly divided into the following 2 groups, 20 in each group:

[0069] (1) Experimental group: conventional feeding + grandiose;

[0070] (2) Blank control group: routine feeding.

[0071] 3. Treatment: Oral administration of Grandesin to experimental pigs, administration method: mixed drink, dose: 5mg / kg b.w., for 30 consecutive days. The death situation was recorded every day, and the death rate of each group was counted after 30 days.

[0072] 4. The r...

Embodiment 2

[0075] The effect of embodiment 2 berberine on the pig infected with African swine fever virus

[0076] 1. Experimental pigs: Located in a farm in Jiangsu Province where an African swine fever epidemic occurred, pregnant sows with no clinical symptoms and positive African swine fever virus infection confirmed by saliva sampling and PCR were selected. Pigs with clinical symptoms were all culled and treated harmlessly. Take biosafety measures in the whole process.

[0077] 2. Grouping: the experimental pigs were randomly divided into 3 groups, namely the experimental group, (10% enrofloxacin soluble powder) control group and blank control group, every group of 50:

[0078] (1) Experimental group: conventional feeding + berberine;

[0079] (2) Control group: (10% enrofloxacin soluble powder);

[0080] (3) Blank control group: routine feeding.

[0081] 3. Treatment: The experimental group was given berberine, administration method: mixed feeding, dose: 20 mg / kg b.w., con...

Embodiment 3

[0086] The effect of embodiment 3 berberine on the pig infected with African swine fever virus

[0087] 1. Experimental pigs: Located in a farm in Jiangsu Province where an African swine fever epidemic occurred, select lactating sows that have no clinical symptoms and are confirmed positive for African swine fever virus by saliva sampling and PCR. Pigs with clinical symptoms were all culled and treated harmlessly. Take biosafety measures in the whole process.

[0088] 2. Grouping: The experimental pigs were randomly divided into two groups, the experimental group and the blank control group, with 30 pigs in each group:

[0089] (1) Experimental group: conventional feeding + berberine;

[0090] (2) Blank control group: routine feeding.

[0091] 3. Treatment: The experimental group was given berberine, administration method: mixed drink, dose: 1kg / ton of drinking water, free to drink, continuous use. The death situation was recorded every day, and the death rate of each grou...

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Abstract

The invention discloses an application of an isoquinoline compound to preparation of an antiviral product. Through experiments, the invention proves that the isoquinoline compound can prevent and / or treat diseases caused by various viruses. Moreover, the isoquinoline compound also has the effects of resisting bacteria, inflammation and platelet aggregation, promoting growth and the like during virus resistance. The invention provides new medical application of the isoquinoline compound, provides a new effective way for prevention and / or treatment of diseases caused by virus infections, is an efficient and safe prevention and treatment means, and has an excellent clinical application prospect.

Description

technical field [0001] The invention belongs to the field of animal disease prevention and treatment. It particularly relates to the use of isoquinoline compounds or their salts in the preparation of antiviral products. Background technique [0002] A virus is a non-cellular life form, which is composed of a long chain of nucleic acid and a protein shell. The virus has no metabolic mechanism of its own, and no enzyme system. Therefore, when the virus leaves the host cell, it becomes a chemical substance without any life activities and cannot reproduce itself independently. Once it enters the host cell, it can use the material and energy in the cell and the ability of replication, transcription and translation to produce a new generation of viruses like it according to the genetic information contained in its own nucleic acid. Virus infection mainly includes injection invasion, endocytosis, membrane fusion or other special invasion methods. Endosomes are a compartment of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P31/14A61P31/12A61P31/04A61P7/02A61P3/00
CPCA61K31/4375A61P31/14A61P31/12A61P31/04A61P7/02A61P3/00A61K2300/00Y02P20/55
Inventor 王永东操基元祝诗发张晨光程稳黄志鹏
Owner GENIFARM LAB INC
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