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Compositions that protect cells from oxidative and mitochondrial stress

A composition and cell technology, which can be used in drug combinations, skin care preparations, cosmetics, etc., to solve problems such as genome instability, DNA protection and repair ability decline, etc.

Pending Publication Date: 2021-02-26
努其杜有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Decreased DNA protection and repair capacity is an important cause of genome instability

Method used

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  • Compositions that protect cells from oxidative and mitochondrial stress
  • Compositions that protect cells from oxidative and mitochondrial stress
  • Compositions that protect cells from oxidative and mitochondrial stress

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] SIRT1 expression

[0136] Changes in SIRT1 expression in PBMC (peripheral blood mononuclear cells) of clinical participants were analyzed using Western blot analysis. SIRT1 expression was significantly increased within 16 days of exposure to our composition. Increased SIRT1 expression indicates that our composition activates beneficial downstream pathways associated with enhanced DNA repair.

[0137] see figure 1 .

[0138] Clinical Outcomes: Proteomics

[0139] Quantities of proteins associated with aging were determined as a function of composition using mass spectrometry.

[0140] Increased abundance of mitochondrial proteins detected in volunteer samples, including:

[0141] Fumarate hydratase: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in energy production in the form of NADH.

[0142] Aspartate transaminase: Catalyzes the transamination of the L-tryptophan metabolite L-kynurenine to f...

Embodiment 2

[0153] HDF Results: Protection Against Oxidative Stress

[0154] Preprocess with NAM or a combination

[0155] Subsequent exposure to oxidative stress (tbh7ox)

[0156] Measure cell viability to assess protection against oxidative stress

[0157] Our Composition Offers Better Protection Than Niacinamide

[0158] The composition is required to produce this enhanced protection as predicted by systems pharmacology

[0159] The composition is alpha lipoic acid, apigenin, ascorbic acid, zinc citrate, niacinamide and quercetin. The results are shown in figure 2 middle.

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Abstract

There are described compositions comprising an effective amount of a combination of two or more components, said components selected from acacetin, ACT1 peptide, alpha-lipolic acid, alprostadil, anisomycin, apigenin, ascorbic acid, astragalus, berberine, beta-lapachone, beta-hydroxy-beta-methyl-butyrate, bacopa monnieri, catechin, catechol, chamomile, chrysin, coumestrol, curcumin, dinitrophenol,dinoprost, ellagic acid, (-)-epigallocatechin gallate, green tea extract, fisetin, genistein, ginsenoside RE, glabridin, 18-alfa-glycyrrhetinic acid, 18-beta-glycyrrhetinic acid, glycyrrhizin, hydroquinone, isoquercitrin (EMIQ), kaempferol, kuromanin, leucine, lithium, luteolin, luteolin, luteolinidin, melatonin, menadione, 1-methylnicotinamide (MNA), methyl salicylate, myricetin, nadide, niacin (vitamin B3), nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), nicotinic acid adenine dinucleotide (Na AD), nicotinic acid mononucleotide (Na MN), parsley (petroselinium crispum), phenylephrine, pokeweed mitogen, 15-Delta prostaglandin J2, puromycin, quercetin, quinolinic acid, retinoic acid, trichostatin A, troxrutin, rutin, tryptophan, vitamin D3, withaferin A, wortmannin and zinc (including salts thereof).

Description

technical field [0001] The present invention relates to novel compositions commonly used for oral or topical application to alleviate the effects of aging. [0002] In particular, the present invention relates to compositions and methods for enhancing cellular tolerance to DNA damage, oxidative stress, mitochondrial dysfunction, or enhancing DNA repair capacity. Background technique [0003] Decreased DNA protection and repair capacity is an important cause of genome instability. Genome instability in turn may lead to diseases such as cancer, the risk of which increases exponentially with age. [0004] Protecting DNA and other vital cellular mechanisms from damage and repairing it when damage occurs is critical for highly functioning cells. This protection and repair of cells is often associated with youth and health. Furthermore, these protective and repair functions decline in somatic cells with age and are responsible for the decline of most cellular and tissue functio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/27A61K8/49A61K8/67A61Q19/00A61Q19/08A61K31/352A61K31/375A61K31/455A61K33/30A61P17/00
CPCA61Q19/00A61Q19/08A61K8/27A61K31/375A61K31/455A61K31/352A61K33/30A61K8/4986A61K8/498A61K8/675A61K8/676A61K2300/00A61K31/385A61P39/06A61K8/365A61K2800/5922A61P17/18A61K2121/00A61K2800/92
Inventor 尼古拉·简·康伦马尔科姆·菲利普·央基
Owner 努其杜有限公司
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