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Use of 5,7-dihydroxyflavone and 5,7-dihydroxy-4'-methoxyflavone in inhibiting telomere function

A technology of dihydroxyflavonoids and methoxyflavonoids is applied in the directions of medical preparations containing active ingredients, organic active ingredients, skin diseases, etc., and can solve problems such as uncertainty

Active Publication Date: 2016-04-27
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
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  • Application Information

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Problems solved by technology

However, the effect of 5,7-dihydroxyflavone and 5,7-dihydroxy-4'-methoxyflavone on telomere function has not yet been determined

Method used

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  • Use of 5,7-dihydroxyflavone and 5,7-dihydroxy-4'-methoxyflavone in inhibiting telomere function
  • Use of 5,7-dihydroxyflavone and 5,7-dihydroxy-4'-methoxyflavone in inhibiting telomere function
  • Use of 5,7-dihydroxyflavone and 5,7-dihydroxy-4'-methoxyflavone in inhibiting telomere function

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Embodiment Construction

[0026] The specific embodiments provided by the present invention will be described in detail below in conjunction with the accompanying drawings.

[0027] 1. Materials

[0028] PGL3-Luciferase vector, the vector map is as follows figure 1 Shown, purchased from Promega Company; pCMV-GFP vector, the vector map is as follows figure 2 As shown, it was purchased from Addgene Company; pSXneo270(T2AG3) plasmid was purchased from Addgene Company, and the vector map can be found on the website of Addgene Company http: / / www.addgene.org / ; C33A cervical cancer cell line was obtained from the cell bank of LifeTechnology Company.

[0029] Lipofectamine2000 cell transfection reagent was purchased from Invitrogen; Luciferase / Renilla chemiluminescence kit was purchased from Promega; Hygromycin was purchased from Invitrogen; 5,7-dihydroxy-4'-methoxyflavone (acacetin) and 5 , 7-dihydroxyflavone (chrysin) was purchased from Sigma.

[0030] 2. Methods and Results

[0031] 2.1 Establishment of ...

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Abstract

The invention relates to an application of chrysin and acacetin in restraining telomere functions, and specifically provides an specific application of chrysin and acacetin in preparing drugs taking telomeres as the targets for cancer treatment or anti-aging, wherein the fact that the telomeres are taken as the targets for cancer treatment or anti-aging refers to causing of telomere injury, telomere function loss and genomic instability. According to the application, a TPE (telomere position effect) cell model is used for confirming that the two compounds can cause telomere injury, telomere function loss and genomic instability, and defining the value and the mechanism of chrysin and acacetin in cancer and anti-aging treatment because chrysin and acacetin affect the telomere functions; since the telomeres are the important targets for anti-aging and anti-cancer treatment, the invention broadens the application range of chrysin and acacetin in clinical treatment.

Description

technical field [0001] The present invention relates to new uses of 5,7-dihydroxyflavone and 5,7-dihydroxy-4'-methoxyflavone, specifically, 5,7-dihydroxyflavone and 5,7-dihydroxy-4' Use of '-methoxyflavones in inhibiting telomere function. Background technique [0002] 5,7-dihydroxyflavone (chrysin) is the raw material for the synthesis of anti-cancer, blood lipid-lowering, anti-cardiovascular and cerebrovascular diseases, antibacterial, anti-inflammatory and other drugs, 5,7-dihydroxy-4'-methoxyflavone (Acacia Acacetin) is a natural gum derivative that plays a role in tightening the skin in sensitive formula firming anti-wrinkle powder / firming anti-wrinkle water. These two small molecular substances are anti-cancer, anti-inflammatory drugs and cosmetics. Important added ingredients. The structural formulas of the two are as follows: [0003] [0004] Although it is known that 5,7-dihydroxyflavone and 5,7-dihydroxy-4'-methoxyflavone can be used as anti-cancer and ant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P35/00A61P17/00
Inventor 叶静陆一鸣魏波华应亦林梁慧欣
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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