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Method for analyzing all components of angelica sinensis six-yellow decoction

A technology of Angelica Liuhuang Decoction and analysis method, which is applied in the directions of analysis materials, material separation, measurement devices, etc., and can solve the problems of inability to perform qualitative analysis, low sensitivity, and inability to achieve comprehensive composition analysis.

Pending Publication Date: 2021-01-15
山东宏济堂制药集团股份有限公司
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  • Abstract
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Problems solved by technology

[0003] However, there are certain limitations and deficiencies in the current research on the ingredients of Danggui Liuhuang Decoction: (1) The content determination methods mainly focus on the determination of the ingredients in the prescription single herb and the ingredients detected in the Pharmacopoeia; (2) The existing research on Danggui Liuhuang Decoction The sensitivity of the component detection method is low, and the component with a low content cannot be detected
(3) Due to the low separation degree of HPLC, most of the components in the fingerprint of Danggui Liuhuang Decoction were not well separated, and qualitative analysis could not be performed, so comprehensive component analysis could not be achieved
However, the composition of effective substances in traditional Chinese medicine compound is complex, and its influence is not the cumulative effect of individual components, but the interaction between components. The content of a single component cannot fully reflect the quality of the compound and cannot achieve the overall quality of Danggui Liuhuang Decoction. control

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  • Method for analyzing all components of angelica sinensis six-yellow decoction

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Embodiment Construction

[0025] In order to clearly illustrate the technical features of this solution, the present invention will be described in detail below through specific implementation modes. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the application.

[0026] 1. Instruments, reagents and materials

[0027] 1.1 Instrument

[0028] Ultra-high performance liquid chromatography Agilent 1290; quadrupole time-of-flight mass spectrometer Agilent 6530C; 1 / 10,000 electronic balance BSASS4S-CW, Sartorius; 1 / 100,000 electronic balance XS105, Mettler; ultrasonic cleaner KQ- 300DE, Shenzhen Kejie Instrument Co., Ltd.; high-speed pulverizer Zhejiang Yili Industry and Trade Co., Ltd.; No. 1 pharmacopoeia sieve (10 mesh), No. 3 pharmacopoeia sieve (50 mesh), No. 9 pharmacopoeia sieve (200 mesh); rotary evaporator YRE -2000A, Gongyi City Yuhua Instrument Co., Ltd.; vacuum freeze dryer BK-FD18BP, Shandong Boke Biological Industry Co., ...

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Abstract

The invention provides a method for analyzing all components of an angelica sinensis six-yellow decoction, and belongs to the technical field of pharmaceutical analysis. An ultra-high performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) technology is adopted to detect an angelica sinensis six-yellow decoction sample, and 15 chemical reference substances are adopted at the same time: baicalin, wogonoside, berberine hydrochloride, epiberberine hydrochloride, coptisine hydrochloride, palmatine hydrochloride, phellodendrine hydrochloride, astragaloside, calycosin-7-glucoside, ferulic acid, chlorogenic acid, ligustilide, verbascoside, baicalein and wogonin are adopted to confirm a detection result of the angelica sinensis six-yellow decoction andclearly identify 68 components; comprehensive analysis of the components of the angelica sinensis six-yellow decoction is realized, and the reliability of quality control is improved.

Description

technical field [0001] The invention belongs to the technical field of drug analysis, and in particular relates to an analysis method for all components of Danggui Liuhuang Decoction. Background technique [0002] Danggui Liuhuang Decoction was first recorded in Li Dongyuan's "Lan Shi Mi Zang" in the Jin Dynasty. It is composed of 7 traditional Chinese medicines: Angelica, Rehmannia glutinosa, Rehmannia glutinosa, Cortex Phellodendri, Scutellaria baicalensis, Coptis chinensis, and Astragalus membranaceus. Treatment of perimenopausal syndrome, hyperthyroidism, skin diseases, viral myocarditis, chronic oral ulcers, chronic prostatitis and other diseases. At present, the research on Danggui Liuhuang Decoction is mainly focused on the clinical application. The chemical composition research is mainly to use high-performance liquid chromatography (HPLC) to establish fingerprints and analyze the effects of calycosin glucoside, verbascoside, ferulic acid, coptisine, and baicalin. ,...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/72G01N30/86
CPCG01N30/02G01N30/06G01N30/34G01N30/7266G01N30/8675G01N2030/047
Inventor 姚元成李凤英姜娟娟孟兆青曹桂云罗湘高伟
Owner 山东宏济堂制药集团股份有限公司
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