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Preparation method of titanium implant with surface-controllable micro-nano composite structure biological membrane

A micro-nano composite structure and implant technology, which is applied in the direction of surface reaction electrolytic coating, prosthesis, drug delivery, etc., can solve the problems of uneven composition, irregular surface morphology of the film layer, and insufficient bonding strength, etc., to achieve Effects of long service life, promoting cell adhesion, strong meshing strength and self-locking ability

Active Publication Date: 2021-01-05
HUAZHONG UNIV OF SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparation of micro-nano composite structure film on the surface of titanium alloy mostly adopts sandblasting and acid-base etching treatment, but the surface morphology of the film formed by sandblasting and acid-base etching treatment is irregular, the composition is not uniform, and the bonding strength is not enough.

Method used

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  • Preparation method of titanium implant with surface-controllable micro-nano composite structure biological membrane
  • Preparation method of titanium implant with surface-controllable micro-nano composite structure biological membrane
  • Preparation method of titanium implant with surface-controllable micro-nano composite structure biological membrane

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preparation example Construction

[0035] In general, the method for preparing a titanium implant with a surface-controllable micro-nano composite structure biofilm in the present invention comprises the following steps:

[0036] (1) Design titanium implant models (including pure titanium implants and titanium alloy implants) with specific topography (such as skewness, undulation, etc.) on the surface;

[0037] (2) The pre-set implant model is printed into shape by laser selective melting (SLM) technology in the additive manufacturing method;

[0038] (3) The plasma micro-arc oxidation (PEO) technology and hydrothermal post-treatment or electrophoretic deposition post-treatment are used to in-situ generate a hydroxyapatite film layer with nanopores on the surface of the titanium implant. Among them, the plasma micro-arc oxidation (PEO) technology was used to generate TiO in situ on the surface of the primary titanium implant. 2 / Ca 3 (PO 4 ) 2 Composite biofilm layer (that is, calcium-phosphorus biofilm lay...

Embodiment 1

[0042] A method for preparing a titanium implant with a surface controllable micro-nano composite structure biofilm, comprising the following steps:

[0043] (1) Design a titanium implant model with micron pores on the surface. The matrix material of the model is Ti-6Al-4V. The surface of the model is composed of a series of rounded frustum-shaped pits. 100μm, the depth is 100μm, and the pit pitch is 1mm.

[0044] (2) Using SLM technology to print the preset implant model. In the SLM process, the laser power is 150W, the spot diameter is 0.1mm, the scanning distance is 0.1mm, the powder coating thickness is 0.04mm, and the scanning speed is 1.2m / s.

[0045] (3) After polishing the implant matrix with 240#, 800#, 1200# sandpaper, wash it with acetone and deionized water.

[0046] (4) Electrolyte is configured, and the electrolyte is composed of calcium acetate of 0.05mol / L, sodium dihydrogen phosphate of 0.02mol / L, and EDTA-Na of 0.01mol / L.

[0047] (5) A micro-arc oxidation...

Embodiment 2

[0051] A method for preparing a titanium implant with a surface controllable micro-nano composite structure biofilm, comprising the following steps:

[0052] (1) Design a titanium implant model with micro-pores on the surface. The matrix material of the model is pure titanium. The surface of the model is composed of a series of rounded frustum-shaped pits. is 1000 μm, and the pit pitch is 1.5 mm.

[0053] (2) Using SLM technology to print the preset implant model. In the SLM process, the laser power is 200W, the spot diameter is 0.1mm, the scanning distance is 0.1mm, the powder coating thickness is 0.04mm, and the scanning speed is 1m / s.

[0054] (3) After polishing the implant matrix with 240#, 800#, 1200# sandpaper, wash it with acetone and deionized water.

[0055] (4) Electrolyte is configured, and the electrolyte is composed of 0.2mol / L calcium acetate, 0.1mol / L sodium dihydrogen phosphate, and 0.04mol / L EDTA-Na.

[0056] (5) A micro-arc oxidation device with an AC pow...

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Abstract

The invention belongs to the field of biomedical materials, and discloses a preparation method of a titanium implant with a surface-controllable micro-nano composite structure biological membrane. Thepreparation method comprises the following steps of (1), designing a titanium implant model with micron pores on the surface; (2), printing and forming the titanium implant model by adopting a selective laser melting (SLM) technology in an additive manufacturing method to obtain a titanium implant primary product; and (3), generating a hydroxyapatite film layer with a micro-nano composite structure on the surface of the titanium implant primary product in situ by adopting a plasma micro-arc oxidation (PEO) technology in cooperation with hydrothermal method post-treatment or electrophoretic deposition method post-treatment, so as to obtain a titanium implant finished product. The detail structure design of the implant and the overall process flow design of the preparation method are improved for simulating the biological bone tissue structure, the micro-nano composite structure biological membrane layer with controllable surface morphology and components is obtained, and the bonding efficiency and bonding strength of the implant and surrounding tissues can be improved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more specifically relates to a method for preparing a titanium implant with a surface-controllable micro-nano composite structure biofilm. Background technique [0002] Due to their excellent mechanical properties, low density, good corrosion resistance, and good biocompatibility, titanium and titanium alloys have become the most commonly used metal implant materials in clinical practice, especially in the fields of joint replacement and tooth restoration. However, the high melting point, high activity, large deformation resistance and poor cutting ability of titanium and its alloys make it difficult to process and manufacture, and complex structures are difficult or even impossible to manufacture. Due to the use of computer-aided design for slicing and layer-by-layer processing of the three-dimensional part model, the laser selective melting (SLM) technology completely eliminates the rest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F3/105B22F3/24C25D11/26A61L27/06A61L27/32A61L27/56A61L27/50B33Y10/00B33Y40/20
CPCA61L27/06A61L27/32A61L27/50A61L27/56A61L2400/18A61L2420/02A61L2430/02B22F3/24B22F2003/242B33Y10/00B33Y40/20C25D11/024C25D11/026C25D11/26Y02P10/25
Inventor 陈颖赵峰余圣甫史玉升吴甲民
Owner HUAZHONG UNIV OF SCI & TECH
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