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Antibacterial coating with bacterial enzyme response function, functional material with antibacterial coating and preparation method of functional material

An antibacterial coating, functional material technology, applied in coatings, epoxy coatings, antifouling/underwater coatings, etc., can solve problems such as high biological toxicity, body inflammation and immune response

Active Publication Date: 2020-12-25
WEIGAO HLDG +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Bactericidal surfaces, such as quaternary ammonium salt surfaces, can effectively kill bacteria, but they are highly toxic and can easily cause inflammation and immune responses in the body

Method used

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  • Antibacterial coating with bacterial enzyme response function, functional material with antibacterial coating and preparation method of functional material
  • Antibacterial coating with bacterial enzyme response function, functional material with antibacterial coating and preparation method of functional material
  • Antibacterial coating with bacterial enzyme response function, functional material with antibacterial coating and preparation method of functional material

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preparation example Construction

[0191] The present invention provides a method for preparing a functional material with an antibacterial coating described in any one of the above technical solutions, characterized in that it comprises the following steps:

[0192] 1) will have formula (I A ) structure of the alkylamine, the compound containing the R structure and a solvent for polymerization reaction, the first intermediate is obtained after precipitation;

[0193]

[0194] The compound containing R structure is selected from formula (I R1 )~(I R3 ) any one or more of the structures shown in );

[0195]

[0196] Wherein, n1, n2 or n3 are each selected from an integer greater than or equal to 1;

[0197] 2) reacting the first intermediate, phosphorus trichloride, organic base and solvent obtained in the above steps, and then dialysis to obtain the second intermediate;

[0198] 3) the second intermediate obtained in the above steps, having R 1 x 1 Monomer of structure, with R 2 x 2 The monomer of...

Embodiment 1

[0314] a. Dissolve 0.48g of n-hexylamine and 1.65g of ethylene glycol glycidyl ether in 25mL of dimethyl sulfoxide, react at 50°C for 12h, precipitate and centrifuge with 125mL of ether, wash the precipitated product 3 times with ether and put it in Vacuum drying in a vacuum oven for 12 hours;

[0315] b. Dissolve the product of step a in 20 mL of dimethyl sulfoxide to form a 40 mg / mL solution, add dropwise 0.015 mL of phosphorus trichloride and 0.02 mL of pyridine, react at room temperature for 3 hours, and put the product into a dialysis bag with a molecular weight cut-off of 3000 Da Dialysis in deionized water for 24 hours, the product was completely frozen in a refrigerator at -20°C, and then freeze-dried on a lyophilizer for 24 hours to remove moisture and collect the product;

[0316] c. Dissolve 200 mg of the product of step b, 20 mg of methyl iodide and 18.8 mg of 3-benzoylbenzyl bromide in 30 mL of dimethyl sulfoxide, react at 60°C for 8 hours, precipitate the reacted...

Embodiment 2

[0320] a. Dissolve 0.95g of n-dodecylamine and 1.80g of propylene glycol diglycidyl ether in 32mL of dimethyl sulfoxide, react at 55°C for 18h, and then precipitate with 125mL of n-hexane. The precipitated product is washed 5 times with n-hexane and then vacuum-dried for 12h ;

[0321] b. Dissolve the product of step a in 25mL dimethyl sulfoxide to make a 40mg / mL solution, add dropwise 0.02mL of phosphorus trichloride and 0.03mL of pyridine, react at room temperature for 4.5h, and put the product into a dialysis bag with a molecular weight cut-off of 3000Da The product was dialyzed in deionized water for 24 hours, and the product was completely frozen in a refrigerator at -20°C, and then freeze-dried on a lyophilizer for 24 hours to remove moisture and collect the product;

[0322] c. Dissolve 200 mg of the product of step b, 120 mg of ethyl bromide and 54 mg of anthraquinone-2-carboxylic acid in 50 mL of dimethyl sulfoxide, react at 60°C for 8 hours, and post-process to obtai...

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Abstract

The invention provides an antibacterial coating. The antibacterial coating comprises a zwitterionic polymer with a structure shown in a formula (I) or a formula (II). The zwitterionic polymer designedby the invention can conform to the development process of bacteria, a quaternary ammonium salt group with positive electricity and a phosphate radical group with negative electricity exist on the zwitterionic polymer to form a zwitterionic surface, and when the surface of a material is infected by bacteria, the surface of the material is an anti-adhesion surface initially, so that the function of bacterial adhesion resistance is achieved. Once phosphate radicals on the surface are easily released by bacterial enzymes generated by metabolism of bacteria growth and propagation, the surface isimmediately converted into a cationic sterilization surface. The construction of the surface not only effectively prevents the initial adhesion of bacteria, but also has good biocompatibility to organisms, and more importantly, when the initial defensiveness is broken through, the surface can be converted into an excellent sterilization function. The preparation process is simpler, the equipment requirement is low, the operation is easy, and the feasibility is high.

Description

technical field [0001] The invention belongs to the field of antibacterial medical devices, and relates to an antibacterial coating, a functional material with an antibacterial coating and a preparation method thereof, in particular to an antibacterial coating with a bacterial enzyme response function and an antibacterial coating with a bacterial enzyme response function Functional materials and methods for their preparation. Background technique [0002] Bacteria are ubiquitous in the environment and in the human body, and pathogenic bacteria that cause human diseases pose a serious threat to public health. The most common bacterial-derived diseases are foodborne diseases, urinary tract infections, sexually transmitted infections, and nosocomial infections. The adhesion, growth and reproduction of bacteria on the surface of materials, and even the formation of biofilms are the main reasons for the failure of implantation of medical materials. Similarly, the adhesion, proli...

Claims

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Application Information

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IPC IPC(8): C09D163/00C09D5/14C08G59/14C08J7/056C08L83/04C08L27/06
CPCC08G59/1422C08G59/1494C08J2327/06C08J2383/04C09D5/14C09D163/00C08J7/0427
Inventor 张桢焱周容涛万雪闫顺杰刘洋张帅栾世方殷敬华
Owner WEIGAO HLDG
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