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Iodine-loaded titanium alloy implant with functions of resisting bacteria and promoting osteogenic differentiation and mineralization, and preparation method of iodine-loaded titanium alloy implant

A titanium alloy and implant technology, which is applied in the field of iodine-loaded titanium alloy implants and its preparation, can solve the problems of strict electrolyte preparation conditions and high cost of electroplating process equipment, and achieve significant osteogenic differentiation and mineralization. Promote the formation of calcium and phosphate mineralization layer and increase the effect of iodine loading

Active Publication Date: 2020-09-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high cost of electroplating process equipment, strict electrolyte preparation conditions, and various factors affecting electroplating conditions, the expansion of production and application in regions with different economic development has been restricted to a certain extent.

Method used

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  • Iodine-loaded titanium alloy implant with functions of resisting bacteria and promoting osteogenic differentiation and mineralization, and preparation method of iodine-loaded titanium alloy implant
  • Iodine-loaded titanium alloy implant with functions of resisting bacteria and promoting osteogenic differentiation and mineralization, and preparation method of iodine-loaded titanium alloy implant
  • Iodine-loaded titanium alloy implant with functions of resisting bacteria and promoting osteogenic differentiation and mineralization, and preparation method of iodine-loaded titanium alloy implant

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of Example 1 Iodine-loaded Titanium Alloy Implant (1)

[0032] 1. Titanium sheet surface modified polydopamine (Ti-PDA)

[0033] First, the titanium alloy Ti6AL4V (Zhejiang Kehui Medical Co., Ltd.) was immersed in a 5M NaOH solution, and reacted at 80° C. for 18 h under continuous magnetic stirring. The titanium sheet was taken out and ultrasonically cleaned with deionized water for 3 times, each time for 5 min, and dried in a fume hood. Then the titanium sheet was immersed in 2 mg / ml dopamine Tris-HCl (pH=8.5) solution, reacted at room temperature for 12 hours, ultrasonically cleaned three times with deionized water, and dried in a fume hood.

[0034] 2. Covalently bonded iodine (Ti-I) on the surface of titanium sheet

[0035] Use 0.1M potassium iodide solution as solvent to prepare 3% povidone iodine / potassium iodide (PVP-I 2 / KI) solution, the state of magnetic stirring was continued at room temperature for 30 min. Subsequent immersion of Ti-PDA in PV...

Embodiment 2

[0052] Embodiment 2 Preparation of the iodine-loaded titanium alloy implant of the present invention (two)

[0053] 1. Titanium sheet surface modified polydopamine (Ti-PDA)

[0054] First, the titanium alloy Ti6AL4V (Zhejiang Kehui Medical Co., Ltd.) was immersed in a 5M NaOH solution, and reacted at 80° C. for 10 h under continuous magnetic stirring. The titanium sheet was taken out and ultrasonically cleaned with deionized water for 3 times, each time for 10 min, and dried in a fume hood. Then the titanium sheet was immersed in 2 mg / ml dopamine Tris-HCl (pH=9) solution, reacted at room temperature for 10 h, ultrasonically cleaned 3 times with deionized water, and dried in a fume hood.

[0055] 2. Covalently bonded iodine (Ti-I) on the surface of titanium sheet

[0056] Use 0.1M potassium iodide solution as solvent to prepare 5% povidone iodine / potassium iodide (PVP-I 2 / KI) solution, the state of magnetic stirring was continued for 1 h at room temperature. Subsequent imm...

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Abstract

The invention provides an iodine-loaded titanium alloy implant with functions of resisting bacteria and promoting osteogenic differentiation and mineralization, and a preparation method of the iodine-loaded titanium alloy implant. According to the preparation method, an iodine coating is fixed to a titanium alloy through a covalent grafting and redox reaction method, the prepared iodine coating titanium sheet shows antibacterial performance, can promote osteogenic differentiation of bone marrow mesenchymal stem cells, and can promote generation of a calcium phosphorylation layer in simulated body fluid. The preparation process provided by the invention is simple and feasible, has the advantages of high efficiency, low cost and good repeatability, and can effectively improve clinical defects of an existing titanium alloy implant applied to the orthopedics department, the oral and maxillofacial surgery department and the neurosurgery department can be effectively overcome, so that the occurrence rate of postoperative early infection after the titanium alloy implant is implanted into a body can be reduced, and related complications such as implant looseness caused by excessive inflammatory reaction is reduced.

Description

technical field [0001] The invention relates to the technical fields of orthopedics, oral and maxillofacial surgery, and neurosurgery implants, in particular to an iodine-loaded titanium alloy implant capable of antibacterial, osteogenic differentiation and mineralization, and a preparation method thereof. Background technique [0002] Due to its excellent biocompatibility and biomechanical properties close to the elastic modulus of bone, titanium alloys are widely used clinically as a representative of bone repair implants. However, excellent bone repair implants should not only focus on bone repair and reconstruction, but should also be based on the prevention of complex surgical complications to achieve the best surgical results. Bone infection is one of the most serious complications of orthopedic surgery. The extensive local and systemic infection and inflammatory response and the subsequent bone defect and osteonecrosis greatly delay the postoperative recovery of patie...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/30A61L27/34A61L27/54A61L27/56A61L27/58C23C26/00
CPCA61L27/06A61L27/306A61L27/34A61L27/54A61L27/56A61L27/58A61L2300/106A61L2300/604A61L2400/18A61L2420/08A61L2430/02C23C26/00C08L39/06
Inventor 叶招明刘安滕王锶源王翊凯
Owner ZHEJIANG UNIV
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