Thymus mongolicus essential oil soft capsule for treating bronchitis and therapy of thymus mongolicus essential oil soft capsule

A technology of bronchitis and soft capsules, which is applied in capsule delivery, anti-inflammatory agents, and medical equipment, etc. It can solve the problems of drug resistance, large body damage, and long treatment cycle, so as to avoid the first-pass effect of the liver, Prevent the volatilization of essential oils and the effect of small dosage

Inactive Publication Date: 2020-08-28
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are western medicine and traditional Chinese medicine for the treatment of bronchitis. Western medicine mostly uses antibacterial drugs (penicillins, cephalosporins, macrolides, erythromycin, etc.), cough and expectorant drugs (ambroxol hydrochloride, bromhexine, carboxymethyl, etc.) Cysteine, etc.), antiviral drugs, which are administered orally, intramuscularly or intravenously, or supplemented with aerosol inhalation, have a fast curative effect, but long-term use of antibiotics will cause great damage to the body and are prone to drug resistance sex
Traditional Chinese medicine is mostly decocted and taken with Chinese herbal medicine formula, which can treat both symptoms and root causes, and systemically regulate body functions. However, the treatment cycle is long, the effect is slow, and the dosage is large, which has certain toxic and side effects on the body.

Method used

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  • Thymus mongolicus essential oil soft capsule for treating bronchitis and therapy of thymus mongolicus essential oil soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Extraction of Thyme Essential Oil

[0031] A thyme essential oil soft capsule for treating bronchitis and its therapy. The thyme essential oil is extracted by steam distillation, and the steps are as follows: Weigh 200g of dried and crushed thyme flowers, place them in a round bottom flask, and add 2000ml of distilled water , soaked at room temperature for 12 h, then ultrasonically treated for 30 min, and heated and distilled for 5 h. When there are no more oil droplets on the condenser tube, it means that the distillation is complete. Put the obtained product into a separatory funnel, add an appropriate amount of petroleum ether, shake well and extract. After standing still, take the upper layer, absorb excess water with anhydrous sodium sulfate, transfer to a distillation flask, and evaporate in a vacuum at 45°C. After the petroleum ether evaporates completely, thyme essential oil is obtained, weighed, and stored at 4°C for later use. 0.25% (w / w).

[0032] 2. Pre...

Embodiment 2

[0039] Embodiment 2 In vitro antibacterial test of thyme essential oil

[0040] 1. Materials

[0041] Bacteria tested: Streptococcus, Staphylococcus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa.

[0042] 2. Method

[0043] The inhibitory effect of thyme essential oil in soft capsules on the growth of test bacteria was determined by cup and saucer method and double-layer plate method. Invert the bottom plate first, then absorb 10 mL of the prepared bacterial solution, and mix it into 90 mL of culture medium cooled to about 45°C, so that the final concentration of the bacterial solution is 10 6 ~10 7 cfu / mL to prepare the upper plate with bacteria. After solidification, place a sterile Oxford cup symmetrically on the plate, add 100 μL of the content taken from the soft capsule of Example 1 to the Oxford cup, and carry out three parallel experiments, using sterile water as a blank control. Incubate at 37°C for 24-36 hours, measure the size of the inhibiti...

Embodiment 3

[0049] Example 3 Anti-inflammatory effect of thyme essential oil

[0050] 1. Experimental grouping

[0051] Blank control group: 0.5% Tween-80 saline, orally administered at a dose of 20ml / kg.

[0052] Administration group: take the thyme essential oil soft capsules prepared in Example 1, take out the contents of the soft capsules, and administer them by intragastric administration at a low dose of 0.1 ml / kg and a high dose of 1 ml / kg.

[0053] Positive control group: dexamethasone, administered orally at a dose of 5 mg / kg.

[0054] 2. Method

[0055] Take 40 mice weighing 25.0±1.0 g, half male and half male, 10 mice in each group. On the basis of normal feeding, the blank control group was given intragastric administration of 0.5% Tween-80 normal saline (20ml / kg), and the treatment group was intragastrically administered once a day (low dose 0.1ml / kg, high dose 1ml / kg) , the positive control group was administered dexamethasone (5 mg / kg) for 5 consecutive days. One hour ...

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Abstract

The invention discloses a thymus mongolicus essential oil soft capsule for treating bronchitis and a therapy of the thymus mongolicus essential oil soft capsule. Thymus mongolicus essential oil has relatively strong effects of inhibiting bacteria, resisting viruses, resisting inflammation, resisting allergy, relieving cough, reducing sputum and the like. According to the invention, the thymus mongolicus essential oil is used as a medicinal component to prepare the soft capsule, an electronic heater is used as an administration tool, a mechanical structure of the heater is used to damage the soft capsule, contained essential oil is slowly released, medicine molecules in the essential oil are vaporized in an electric heating manner, and the medicine molecules are inhaled into respiratory tracts through mouths and noses, so that the medicine molecules can deeply and directly reach lesion parts such as tracheas and bronchus to quickly play roles. As a directional administration mode, thetherapy has the advantages of obvious quick-acting effect and positioning effect, local administration, quick effect, small dosage and small toxic and side effects, has obvious curative effects on bronchitis treatment, cough relieving and sputum reduction, and can be used as an effective antibiotic replacement and antibiotic reduction treatment means.

Description

technical field [0001] The invention belongs to the field of natural medicines, in particular to a thyme essential oil soft capsule for treating bronchitis and its therapy. Background technique [0002] Thymus mongolicus Ronn is an ancient plant that has a long history of being used to treat diseases, and its medicinal records in my country can be traced back to the Northern Song Dynasty. "Xinjiang Chinese Herbal Medicine Handbook" records the effects of treating colds, dispelling wind, invigorating the spleen and eliminating food, relieving cough and reducing phlegm, warming the middle and dispelling cold; Cough, whooping cough, sore throat; thyme decoction and gargling can cure pharyngitis and oral inflammation, which has good effect. The ancient Egyptians used thyme for antiseptic, and the ancient Romans used thyme for antibacterial. In the Middle Ages, the plague spread throughout Europe, and Europeans used thyme to treat diseases and leprosy. During the two world war...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/48A61K9/72A61P11/00A61P29/00A61M31/00
CPCA61K9/007A61K9/4825A61K9/4858A61K36/53A61K2236/331A61K2236/55A61M31/00A61P11/00A61P29/00
Inventor 王钲霖刘胜贵薛红芬付彬彬李智高孔令羽蒋永昌马海悦
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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