Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Three-dimensional printing material as well as preparation method and application thereof

A technology of 3D printing and raw materials, which is applied in application, 3D printing, additive manufacturing, etc. It can solve the problems of poor shape and difficulty in restoring bone function, achieve good biocompatibility, promote cell proliferation and osteogenic differentiation, and achieve material properties Promoted effect

Inactive Publication Date: 2020-06-26
SHANGHAI TONGJI HOSPITAL
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the general implants in the past generally have poor appearance, and it is difficult to restore bone function well.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Three-dimensional printing material as well as preparation method and application thereof
  • Three-dimensional printing material as well as preparation method and application thereof
  • Three-dimensional printing material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1 Materials and methods

[0040] 1.1 Main reagents

[0041]Polycaprolactone (polycaprolactone, PCL), polyetheretherketone (poly-ether-ether-ketone, PEEK), polylactic acid (polylactic acid, PLA), poly(lactic-co-glycolic acid copolymer) acid), PLGA), ethyl orthosilicate (TEOS), triethyl phosphate (TEP), hydroxyapatite (Hydroxyapatite, HA) (Mw=502.31g / mol, Mp=1100°C), surfactant P123 , concentrated nitric acid (HNO 3 ), calcium nitrate tetrahydrate (Ca(NO 3 ) 2 4H 2 O), chloral hydrate, and potassium oxalate were all purchased from Sinopharm Chemical Reagent Co., Ltd.; strontium chloride hexahydrate (SrCl 2 ·6H 2 O) was purchased from Merck; trypsin was purchased from Shanghai Pudong Biochemical Reagent Factory; α-MEM culture medium, fetal bovine serum, and PBS solution were purchased from Gibco; CCK-8 kit was purchased from Nanjing Novizan Biotechnology Co., Ltd.

[0042] 1.2 Main instruments

[0043] Ultra-clean bench (BCM-1000, Shanghai Hujing Medical Instrument...

Embodiment 2

[0120] Prepare 3D printing materials, the steps are as follows:

[0121] 1) Preparation of strontium-doped mesoporous bioactive glass (Sr-MBG): Dissolve 3.0g P123 in 120ml 2M nitric acid and 30ml deionized water, stir in a water bath at 37°C until a transparent solution is formed, and then pour into the solution Add 8.5gTEOS, 0.98g TEP, 5.35g Ca(NO 3 ) 2 4H 2 O and 0.67 g SrCl 2 ·6H 2 O, continue to stir in a water bath at 37°C for 12 hours, then transfer the solution to a hydrothermal kettle, perform hydrothermal treatment at 100°C for 48 hours, then transfer the solution to an oil bath at 100°C, and dry to obtain a powder. Finally, it is placed in a sintering furnace and sintered at 650°C to completely remove the surfactant;

[0122] 2) Polycaprolactone is broken into 3mm round particles through a grinder;

[0123] 3) Hydroxyapatite, polylactic acid, polyetheretherketone and the prepared strontium-doped mesoporous bioactive glass are all prepared into nanoparticles (<2...

Embodiment 3

[0126] Prepare 3D printing materials, the steps are as follows:

[0127] 1) Preparation of strontium-doped mesoporous bioactive glass (Sr-MBG): Dissolve 3.0g P123 in 120ml 2M nitric acid and 30ml deionized water, stir in a water bath at 37°C until a transparent solution is formed, and then pour into the solution Add 8.5gTEOS, 0.98g TEP, 5.35g Ca(NO 3 ) 2 4H 2 O and 0.67 g SrCl 2 ·6H 2 O, continue to stir in a water bath at 37°C for 12 hours, then transfer the solution to a hydrothermal kettle, perform hydrothermal treatment at 100°C for 48 hours, then transfer the solution to an oil bath at 100°C, and dry to obtain a powder. Finally, it is placed in a sintering furnace and sintered at 650°C to completely remove the surfactant;

[0128] 2) Polycaprolactone is broken into 3mm round particles through a grinder;

[0129] 3) Hydroxyapatite, polylactic acid, polyetheretherketone and the prepared strontium-doped mesoporous bioactive glass are all prepared into nanoparticles (<2...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a three-dimensional printing material as well as a preparation method and application thereof. The method uses polycaprolactone, hydroxyapatite, polylactic acid, polyether ether ketone and strontium doped mesoporous bioactive glass as raw materials to successfully prepare the composite material for 3D printing, and mechanical performance tests and biological experiments confirm that the obtained material has excellent mechanical properties, can significantly promote cell proliferation and osteogenic differentiation, has no hemolysis, has good biocompatibility, and canbe degraded in vivo, and therefore the composite material can be used to prepare a medical artificial bone to treat bone injury, such as orbital zygomatic jaw complex injury.

Description

technical field [0001] The present invention relates to the fields of manufacture and application of new biomedical materials and medical devices, in particular, to a three-dimensional printing material, its preparation method and its clinical application (such as repairing orbitozygomatic complex damage). Background technique [0002] The anatomical structure of the craniofacial region is complex, adjacent to many important tissues, and facial expressions carry human social functions, which have a huge impact on the quality of life of individuals. Therefore, facial restoration and reconstruction have extremely high requirements for accuracy. The goal of reconstructive craniofacial surgery is to restore both aesthetics and function. With the help of ever-changing computer and intelligent manufacturing technology, continuous improvement of pre-operative simulation, material design and manufacturing, precise repair, and rehabilitation evaluation are the scientific research pro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/04A61L27/10A61L27/50A61L27/54A61L27/58A61F2/28B33Y10/00B33Y70/10B33Y80/00
CPCA61F2/2875A61F2002/2878A61F2002/30948A61F2002/30985A61L27/047A61L27/10A61L27/12A61L27/18A61L27/50A61L27/54A61L27/58A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L67/04C08L61/16
Inventor 崔海燕王国宝
Owner SHANGHAI TONGJI HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com