Application of ginseng and jujube brain-strengthening oral liquid to preparation of drug for preventing and/or treating Alzheimer disease (AD)

Abstract

The invention discloses new application of ginseng and jujube brain-strengthening oral liquid, and particularly relates to application of the ginseng and jujube brain-strengthening oral liquid to preparation of a drug for preventing and / or treating Alzheimer disease (AD). The ginseng and jujube brain-strengthening oral liquid is purchased from the Tonghua Renmin Pharmaceutical Co., Ltd., and is generally used for treating symptoms, such as palpitation and shortness of breath, insomnia and dreaminess, mental fatigue and weakness, and lassitude in loin and legs, caused by neurasthenia. It is found in the experiment process that the drug can act on multiple disease links of AD, the cognitive function of AD can be improved, and the drug has the effects of reducing A beta deposition in brain tissue, inhibiting cell apoptosis, inhibiting oxidative stress, promoting neurotrophic factor secretion, improving the brain tissue environment, promoting neuron survival and improving the cognitive function. New indications are increased for clinical use of the product, and the ginseng and jujube brain-strengthening oral liquid can be designed into a multi-target drug for treating AD and thus has huge application value.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the new application of Shenzao Jiannao Oral Liquid in the preparation of drugs for preventing and / or treating Alzheimer's disease (or known as senile dementia). Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a common central nervous degenerative disease in middle-aged and elderly people, with progressive memory loss and cognitive dysfunction as the main manifestations. With the aging population in our country, the incidence of AD is increasing year by year, and it has become a social and medical problem that needs to be solved urgently. The typical pathological features of AD are senile plaques and neurofibrillary tangles in the cerebral cortex and hippocampus, and the persistent inflammatory response and oxidative stress damage around the lesion lead to the loss of a large number of neurons and the atrophy of brain tissue. Alkaliergic neuron...

AI Technical Summary

Problems solved by technology

But this traditional Chinese medicine combination has the following defects: (1) the drug combination is aimed at a single disease model (1. Amanitic acid-induced rat AD model, 2. β-amyloid-induced AD rat model, 3. APP / PS1 transgenic mice (2) the drug combination can improve the learning and memory ability of AD model animals to a certain extent, and improve brain tissue damage , but it does not mention whether it can repair damaged neurons, and if the lost neurons cannot be effectively replenished and replaced, the long-term effect of its treatment of AD is limited

But there is following defect in this Chinese medicine combination: although this pharmaceutical composition can effectively alleviate the dementia symptom of vascular dementia model rat, it is not effective to more common, more complicated senile dementia (being Alzheimer's disease) of pathogenesis. good

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