High-extension, high-adhesion and high-self-healing double network hydrogel and preparation method and application thereof

Abstract

The invention provides a a design strategy of a novel adhesive hydrogel material and obtains a high-extension, self-healing, and high-adhesion biocompatible hydrogel material. Based on a double network structure design principle, polymerizable polyethylene glycol-based high polymer constitutes a first covalent crosslinked network, and hydrophilic high polymer with ultra-high molecular weight forms a second noncovalent crosslinked network through entanglement. A mesh size of a first network is larger than a molecular effective size of second network high polymer, and molecular weigh of high polymer forming a second network should be larger than a critical entanglement molecular weight thereof, so that effective molecular entanglement is formed, high-extension, self-healing, and high-adhesion characteristics are given to double network hydrogel. The novel hydrogel can rapidly and repeatedly form stable adhesion with surfaces of various materials. Damaged by an external force, the hydrogel can rapidly and repeatedly perform self healing. The material can be used as a cell cultivating carrier, a sewing-free novel dressing, and can be applied to wearble sensors.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a high-stretch, high-viscosity, self-healing double-network hydrogel for tissue adhesion, a preparation method and application thereof. Background technique [0002] Hydrogel is a cross-linked hydrophilic polymer, which is composed of a porous gel network, rich in water, allowing the exchange of oxygen and nutrient metabolites, and has viscoelastic characteristics similar to human ECM, so it is widely used It can be used as a platform for studying three-dimensional cellular microenvironment and cell interaction, or as a substrate for constructing engineered tissues. However, most traditional hydrogels are composed of permanent covalent bonds or long-term stable strong physical bonds, and their mechanical characteristics are mainly elastic. There are still many problems in tissue engineering applications: 1) Covalent bonds or long-term stable strong physical bonds Th...

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Problems solved by technology

However, most traditional hydrogels are composed of permanent covalent bonds or long-term stable strong physical bonds, and their mechanical characteristics are mainly elastic, so there are still many problems in tissue engineering applications: 1) Covalent bonds or long-term stable strong physical bonds The pore size of the cross-linked gel network is small, which makes the mass transfer efficiency of the cells inside the gel low and tends to apoptosis; 2) The chemically cross-linked hydrogel network area is rigid, so it can be used as a three-dimensional extracellular matrix for three-dimensional cell culture 3) Traditional hydrogels do not form adhesion to the contacting tissue / matrix surface due to the hydrophilic surface, so they are usually used to avoid Non-specific adsorption of macromolecules is used to avoid the adhesion of substances on its surface; 4) Traditional single-network hydrogels often have poor mechanical properties and cannot meet the requirements of higher mechanical properties such as high strength and high toughness

The existing commercial tissue adhesives for clinical application mainly realize the adhesion with tissues through chemical crosslinking and curing reactions, such as (CA, Dermabond, US)) (S.C. Woodward, J.B. Herrmann, J.L. Cameron, G. Brandes, E.J. Pulaski, F. Leonard, Annals of Surgery 1965, 162, 113.) and Succinimide ester (L.C. Sehl, O.M. Trollsas, D.G. Wallace, D .Toman, F.A.Delustro, J.A.Schroeder, G.H.Chu, Google Patents, 2004) and other tissue adhesive products, therefore all have the problem of cytotoxicity

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