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Functional drug-sustained-release medical dressing constructed by alginic acid aminated derivative/bacterial cellulose nanocrystal composite gel

A composite technology of bacterial cellulose and nanocrystals, used in medical science, bandages, etc., to achieve the effects of controlled release, improved mechanical strength, and uniform pore structure

Active Publication Date: 2019-08-23
HAINAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention utilizes the superior seaweed resources in my country, closely combines the hydrophobic derivatization, physical blending and layer-by-layer assembly methods of alginate, and designs and develops a compound gel constructed of alginate aminated derivatives / bacterial cellulose nanocrystals Functional drug slow-release medical dressings, while solving the defects of a single alginate gel in the application of wound dressings, breaking through technical bottlenecks, and providing technical support for the development and utilization of renewable resources and the research and development of medical dressings

Method used

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  • Functional drug-sustained-release medical dressing constructed by alginic acid aminated derivative/bacterial cellulose nanocrystal composite gel
  • Functional drug-sustained-release medical dressing constructed by alginic acid aminated derivative/bacterial cellulose nanocrystal composite gel
  • Functional drug-sustained-release medical dressing constructed by alginic acid aminated derivative/bacterial cellulose nanocrystal composite gel

Examples

Experimental program
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Effect test

Embodiment B

[0051] The preparation of embodiment BCNs

[0052] Measure 100mL of naturally fermented coconut water, add 1.0g of sucrose, 0.5g of ammonium sulfate, 0.05g of magnesium sulfate and 0.15g of potassium dihydrogen phosphate to it, and mix thoroughly to make a fermentation medium. Before being inoculated with Acetobacter xylinum bacteria, the above-mentioned fermentation medium was sterilized at 120° C. for 30 minutes. Under the conditions of pH=4.0 and room temperature of 30° C., the initial bacterial cellulose gel was obtained by static culture for about 3 to 4 days. Then the bacterial cellulose gel was purified with 0.1mol / L NaOH aqueous solution at 80°C, and finally washed repeatedly with double distilled water until neutral. The obtained film was pulverized by a pulverizer, and then freeze-dried to obtain high-purity bacterial cellulose powder. Subsequently, 10 g of bacterial cellulose powder was dispersed in 100 mL of concentrated sulfuric acid solution with a mass fractio...

Embodiment 1

[0055] In this example, CaCO 3 / GDL complex is the cross-linking agent, and gentamicin is the antibiotic drug to be loaded. In the preparation of medical dressings, the CaCO 3 The molar ratio with GDL is 1:2, CaCO 3 The molar ratio of Ca element in SA to –COOH in SA is 0.36.

[0056] Dissolve 5 g of SA in 200 mL of distilled water, then add 50 mL of absolute ethanol and mix well. Then, 1.72 g (30% sodium alginate uronic acid monomer molar weight) of sodium periodate was added to the above mixed solution, and electric stirring was performed at room temperature for 24 hours in the dark. Add 10 mL of ethylene glycol to the above reaction solution, and magnetically stir for 2 h in the dark to terminate the reaction. The solution after the reaction was terminated was precipitated with 5 g of sodium chloride and 800 mL of absolute ethanol. The resulting precipitate was then redissolved in 100 mL of distilled water, and the solution was precipitated with 3 g of sodium chloride an...

Embodiment 2

[0060] In this example, CaCO 3 / GDL complex is the cross-linking agent, and ofloxacin is the antibiotic drug to be loaded, and in the preparation of medical dressings, the CaCO 3 The molar ratio with GDL is 1:2, CaCO 3 The molar ratio of Ca element in SA to –COOH in SA is 0.18.

[0061] Dissolve 5 g of SA in 200 mL of distilled water, then add 50 mL of absolute ethanol and mix well. Then, 1.72 g of sodium periodate was added to the above mixed solution, and electric stirring was carried out at room temperature for 24 h in the dark. Add 10 mL of ethylene glycol to the above reaction solution, and magnetically stir for 2 h in the dark to terminate the reaction. The solution after the reaction was terminated was precipitated with 5 g of sodium chloride and 800 mL of absolute ethanol. The resulting precipitate was then redissolved in 100 mL of distilled water, and the solution was precipitated with 3 g of sodium chloride and 600 mL of absolute ethanol. After repeating the pre...

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Abstract

The invention relates to medical dressings, particularly relates to a functional drug-sustained-release medical dressing constructed by alginic acid aminated derivative / bacterial cellulose nanocrystalcomposite gel and belongs to the technical field of medical treatment. The functional drug-sustained-release medical dressing provided by the invention is prepared through loading an antibiotic druginto an alginic acid aminated derivative by a physical blending method through taking CaCO3 / GDL as an ion cross-linking system of RAOA and taking bacterial cellulose nanocrystals (BCNs) prepared through hydrolyzing bacterial cellulose by sulfuric acid as a reinforcer, constructing an alginic acid aminated derivative / bacterial cellulose nanocrystal composite gel matrix under the action of ion cross-linking of the CaCO3 / GDL, coating the surface of a matrix material sequentially with positive-charge chitosan (CS) and negative-charge hyaluronic acid (HA) through a layer-by-layer assembling method,and carrying out cross-linking by a chemical cross-linker. A technical support is provided for development and utilization of renewable resources and research and development of the medical dressings.

Description

technical field [0001] The invention relates to a medical dressing, in particular to a functional drug slow-release medical dressing constructed from an alginate aminated derivative / bacterial cellulose nanocrystal composite gel, and belongs to the field of medical technology. Background technique [0002] The development of alginate medical dressings has a history of more than 30 years, but the most developed and applied alginate fiber dressings have been registered and produced by many units, such as Foshan Youte, Taizhou Rongxing, Qingdao Mingyue, etc. Alginate fiber dressing has good absorption effect and stable product performance, but there are also some deficiencies in use. The main manifestations are that it cannot be used for the care of scab wounds, the processing process is long, and the required cost is high. The emergence of alginate gel dressing products has expanded the application range of alginate in the field of medical dressings. This type of emerging dress...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0085A61L26/0066A61L26/0061A61L2300/406C08L1/02C08L5/04
Inventor 颜慧琼陈秀琼林强陈光英包朝玲赵芮胡继森谢秋云
Owner HAINAN NORMAL UNIV
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