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Functional Drug Sustained-release Medical Dressing Constructed by Alginate Aminated Derivatives/Bacterial Cellulose Nanocrystal Composite Gel

A composite technology of bacterial cellulose and nanocrystals, which is applied in medical science, bandages, etc., to achieve the effects of improving the action rate, improving blood coagulation performance, and excellent cell compatibility

Active Publication Date: 2022-07-29
HAINAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention utilizes the superior seaweed resources in my country, closely combines the hydrophobic derivatization, physical blending and layer-by-layer assembly methods of alginate, and designs and develops a compound gel constructed of alginate aminated derivatives / bacterial cellulose nanocrystals Functional drug slow-release medical dressings, while solving the defects of a single alginate gel in the application of wound dressings, breaking through technical bottlenecks, and providing technical support for the development and utilization of renewable resources and the research and development of medical dressings

Method used

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  • Functional Drug Sustained-release Medical Dressing Constructed by Alginate Aminated Derivatives/Bacterial Cellulose Nanocrystal Composite Gel
  • Functional Drug Sustained-release Medical Dressing Constructed by Alginate Aminated Derivatives/Bacterial Cellulose Nanocrystal Composite Gel
  • Functional Drug Sustained-release Medical Dressing Constructed by Alginate Aminated Derivatives/Bacterial Cellulose Nanocrystal Composite Gel

Examples

Experimental program
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Effect test

Embodiment B

[0051] Preparation of Example BCNs

[0052] Measure 100 mL of naturally fermented coconut water, add 1.0 g of sucrose, 0.5 g of ammonium sulfate, 0.05 g of magnesium sulfate and 0.15 g of potassium dihydrogen phosphate into it, and mix thoroughly to prepare a fermentation medium. Before inoculation with Acetobacter xylinum bacteria, the above fermentation medium was autoclaved at 120°C for 30 min. The initial bacterial cellulose gel was obtained by static culture at pH=4.0 and room temperature of 30°C for about 3 to 4 days. The bacterial cellulose gel was then purified with 0.1 mol / L NaOH aqueous solution at 80 °C, and finally washed repeatedly with double distilled water until neutral. The obtained membrane was pulverized with a pulverizer, and then freeze-dried to obtain high-purity bacterial cellulose powder. Subsequently, 10 g of bacterial cellulose powder was dispersed in 100 mL of a concentrated sulfuric acid solution with a mass fraction of 50%, and vigorously stirred...

Embodiment 1

[0055] In this example, CaCO 3 / GDL complex is a cross-linking agent, and gentamicin is an antibiotic drug to be loaded. In the preparation of medical dressings, CaCO was fixed respectively. 3 1:2 molar ratio to GDL, CaCO 3 The molar ratio of Ca element to –COOH in SA is 0.36.

[0056] Dissolve 5 g of SA in 200 mL of distilled water, then add 50 mL of absolute ethanol and mix evenly. Then, 1.72 g (30% molar amount of sodium alginate uronic acid monomer) sodium periodate was added to the above mixed solution, and the mixture was stirred electrically for 24 hours at room temperature in the dark. 10 mL of ethylene glycol was added to the above reaction solution, and the reaction was terminated by magnetic stirring in the dark for 2 h. The quenched solution was precipitated with 5 g of sodium chloride and 800 mL of absolute ethanol. The resulting precipitate was then redissolved in 100 mL of distilled water, and the solution was precipitated with 3 g of sodium chloride and 600...

Embodiment 2

[0060] In this example, CaCO 3 The / GDL complex is the cross-linking agent, and ofloxacin is the antibiotic drug to be loaded. In the preparation of the medical dressing, CaCO was fixed respectively. 3 1:2 molar ratio to GDL, CaCO 3 The molar ratio of Ca to –COOH in SA is 0.18.

[0061] Dissolve 5 g of SA in 200 mL of distilled water, then add 50 mL of absolute ethanol and mix evenly. Then, 1.72 g of sodium periodate was added to the above mixture, and the mixture was electrically stirred at room temperature for 24 h in the dark. 10 mL of ethylene glycol was added to the above reaction solution, and the reaction was terminated by magnetic stirring in the dark for 2 h. The quenched solution was precipitated with 5 g of sodium chloride and 800 mL of absolute ethanol. The resulting precipitate was then redissolved in 100 mL of distilled water, and the solution was precipitated with 3 g of sodium chloride and 600 mL of absolute ethanol. After repeating the precipitation three...

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Abstract

The invention relates to a medical dressing, in particular to a functional drug sustained-release medical dressing constructed by an alginic acid aminated derivative / bacterial cellulose nanocrystal composite gel, and belongs to the field of medical technology. The present invention uses CaCO 3 / GDL is an ionic cross-linking system of RAOA. Bacterial cellulose nanocrystals (BCNs) prepared by hydrolyzing bacterial cellulose with sulfuric acid are used as reinforcing agents. Antibiotic drugs are loaded into alginate aminated derivatives by physical blending. , in CaCO 3 The alginate aminated derivatives / bacterial cellulose nanocrystal composite gel matrix was constructed under the ionic cross-linking of / GDL; the positively charged chitosan (CS) and negatively charged hyaluronic acid ( HA) is sequentially deposited on the surface of the matrix material, and is cross-linked by a chemical cross-linking agent to prepare a functional drug sustained-release medical dressing. Provide technical support for the development and utilization of renewable resources and the research and development of medical dressings.

Description

technical field [0001] The invention relates to a medical dressing, in particular to a functional drug sustained-release medical dressing constructed by an alginic acid aminated derivative / bacterial cellulose nanocrystal composite gel, and belongs to the field of medical technology. Background technique [0002] The development of alginate medical dressings has a history of more than 30 years, but the most developed and applied alginate fiber dressings have been registered and produced by many units, such as Foshan Youte, Taizhou Rongxing, Qingdao Mingyue, etc. The alginate fiber dressing has good absorption effect and stable product performance, but there are some shortcomings in use, which are mainly manifested in that it cannot be used for the care of scab wounds, the processing process is long, and the cost is high. The emergence of alginate gel dressing products has expanded the application scope of alginate in the field of medical dressings. This new type of dressing h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0085A61L26/0066A61L26/0061A61L2300/406C08L1/02C08L5/04
Inventor 颜慧琼陈秀琼林强陈光英包朝玲赵芮胡继森谢秋云
Owner HAINAN NORMAL UNIV
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