Purification technology of colloid compound

Abstract

The invention discloses a purification technology of a colloid compound, and belongs to an important sodium removing step during a drug-almagate preparation process. The purification technology comprises the following steps: mixing the colloid compound with water, stirring, and filtering, thus obtaining a colloid compound crude product; then adding an ion exchanger, stirring, and filtering, thus obtaining a purified colloid compound. According to the purification technology disclosed by the invention, the problems of high raw material cost, complicated technology, complicated operation and thelike existing in the prior art as technologies such as an organic aluminum method, a high-purity aluminum spark discharge method and a sol-gel method are overcome, and the purification technology hasthe advantages that the cost is low, the process is simplified, drying is not required, a sodium reduction effect is remarkable, and the like.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy, and in particular relates to a purification process and application of colloidal compounds. Background technique [0002] Aluminum hydroxide, the chemical formula is Al(OH) 3 , is the hydroxide of aluminum. Aluminum hydroxide can not only react with acid to generate salt and water, but also react with strong base to generate salt and water, so it is also an amphoteric hydroxide. According to the application, it can be divided into two types: industrial grade and pharmaceutical grade. Aluminum hydroxide is heat-resistant, wear-resistant, odorless, non-toxic, non-volatile, and can dehydrate and absorb heat when heated above 250°C. It is an industrial additive with a wide range of uses. Generally, the so-called aluminum hydroxide actually refers to the hydrate of aluminum oxide, such as the white colloidal precipitate obtained by adding ammonia water or weak base to the aluminum salt solution. a...

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Problems solved by technology

(3) High-concentration sodium salt not only inhibits the activity of respiratory tract cells and reduces their ability to resist diseases, but also reduces saliva and lysozyme in the oral cavity, making it difficult to resist viral infections, resulting in various respiratory diseases

(4) The hyperosmotic fluid in sodium salt will damage the gastric mucosa, and the nitrite contained in some pickles and salted foods will be transformed into nitrosamines under the action of gastric acid and bacteria, which is easy to cause gastric cancer

(5) The increase of sodium ions in the body will lead to dehydration of facial cells, increased wrinkles, and aging of the skin

[0005] Chinese patent application CN201310176935.0 discloses a method for removing sodium during the preparation of high-purity alumina, including purification, secondary purification, water washing, drying, secondary water washing, and drying steps, specifically including the steps of removing sodium Grind the aluminum hydroxide to ≤500μm, stir and wash 2~3 times in a constant temperature water bath at 50~55℃ with the sodium removing agent Ⅰ to obtain pure aluminum hydroxide; wash the purified aluminum hydroxide to pH7.0~7.5, Drying and dehydration; Add sodium remover II to the washed and dried aluminum hydroxide, stir and wash in a constant temperature water bath at 30~50°C for 2~3 times; wash the aluminum hydroxide after secondary purification with 30~50°C pure water After washing, dry and dehydrate to transform into fluffy ultra-low-sodium aluminum hydroxide. The sodium-removing agent I is hydrochloric acid, and the sodium-removing agent II is one of hydrochloric acid, ammonium chloride, and ammonium carbonate. It is alumina in the industrial production process, and it needs to be purified, washed with water, dried, and the steps of secondary purification and drying. The steps in the entire industrial process are cumbersome, raw materials are wasted, and drying and heating steps are required. Therefore Large energy consumption is not conducive to large-scale industrial production. More importantly, a drying step is required, which will cause the newly prepared aluminum hydroxide to lose activity or have low activity, and its sodium reduction effect is not good. significantly

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