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An anti-thrombotic, anti-infection, honeycomb porous structure titanium alloy implant device

A porous structure, titanium alloy technology, applied in the direction of human tubular structure devices, blood vessels, metal processing equipment, etc., to achieve ideal cell activity, improve dynamic coagulation time, and reduce the survival rate of bacteria

Active Publication Date: 2021-12-21
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a titanium alloy implant device with anti-thrombosis, anti-infection and honeycomb porous structure in order to reduce the problem of thrombus formation and bacterial infection leading to the failure of medical implant devices

Method used

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  • An anti-thrombotic, anti-infection, honeycomb porous structure titanium alloy implant device
  • An anti-thrombotic, anti-infection, honeycomb porous structure titanium alloy implant device
  • An anti-thrombotic, anti-infection, honeycomb porous structure titanium alloy implant device

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Embodiment 1

[0039] A preparation method of a titanium alloy super-hemophobic anti-thrombosis anti-infection honeycomb porous structure surface based on electronic dynamic regulation in this embodiment includes the following specific steps:

[0040] Step 1, the NiTi alloy is subjected to optical grade polishing to obtain a mirror-polished nickel-titanium alloy (P-NiTi) sample, the surface roughness of which is less than 5 angstroms;

[0041] Step 2: Clean the mirror-polished titanium alloy sample described in step 1 with an ultrasonic cleaner, the ultrasonic frequency of which is 40KHZ, submerge the surface of the sample with deionized water and absolute ethanol solution respectively, and clean them respectively at room temperature 5min;

[0042] Step 3, drying the cleaned titanium alloy sample described in step 2 with cold air to obtain a clean titanium alloy sample;

[0043] Step 4, build as figure 1 Double-pulse femtosecond laser processing system;

[0044] Step five, using the femto...

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Abstract

The invention relates to an anti-thrombosis, anti-infection and honeycomb porous structure titanium alloy implantation device, which belongs to the technical field of surface modification of metal materials. In this method, different micro-nano composite structures can be prepared by shaping the traditional femtosecond laser into a femtosecond laser double pulse, and then adjusting the local instantaneous electronic state of the material. Through the dynamic regulation of electrons, a unique honeycomb porous structure is finally processed. The structure has a static contact angle of 143.4°±2.6° and a rolling angle of 8.5°±2° against new rabbit blood. Because fluorinated materials have low surface energy, frictional resistance, excellent bactericidal and anti-thrombosis capabilities, the surface of this NiTi alloy with a honeycomb porous structure is fluorinated, and the static contact angle for fresh rabbit blood is obtained as 167.3°±3.2°, a super hemophobic surface with a rolling angle of 1.6°±0.3°, and the obtained surface also has excellent antibacterial properties. The method of the invention is applicable to the surfaces of titanium alloy materials of various sizes and shapes.

Description

technical field [0001] The invention relates to an anti-thrombosis and anti-infection titanium alloy implantation device with a honeycomb porous structure, in particular to a method for preparing the surface of a titanium alloy super-hemophobic anti-thrombosis and anti-infection honeycomb porous structure based on electronic dynamic regulation, which belongs to metal Material surface modification technology field. Background technique [0002] Biomedical implantable devices have been widely used, such as artificial blood vessels, vascular stents, artificial heart valves, and tissue engineering, which have effectively saved the lives of patients and improved their quality of life. Undoubtedly, the most important feature of an implant is biosafety, the ability to coexist with tissue without causing unacceptable damage to the human body. For medical implanted devices that come into contact with blood, biofilm formation and thrombosis are important complications. When these com...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/06A61F2/24A61F2/82A61L27/06A61L27/28A61L27/50A61L27/54A61L27/56B23K26/06B23K26/0622B23K26/36B23P15/00
Inventor 姜澜马云龙胡洁
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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