A pharmaceutical composition, preparation and preparation method for promoting blood circulation, removing blood stasis and lowering blood fat

A technology for promoting blood circulation and removing blood stasis and composition, which is applied in the field of blood lipid-lowering pharmaceutical composition, promoting blood circulation and removing blood stasis, preparations and their preparations, which can solve the problems of obvious toxic and side effects, not treating the root cause of the index, and bad taste, etc., so as to reduce blood cholesterol Concentration, non-toxic and side effects, and the effects of drug resistance

Active Publication Date: 2021-11-12
武汉百理王生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, currently known blood lipid-lowering drugs more or less affect liver function, have obvious toxic and side effects, and the cost is also very expensive.
[0005] For example, antihypertensive and lipid-lowering drugs represented by aspirin have the following deficiencies: (1) the main mechanism of action of aspirin is to inhibit the production of TXA2, anti-platelet aggregation, and thus play an antithrombotic effect
(3) There is dependence, long-term use will increase the risk of bleeding in patients, and it cannot regulate blood pressure in both directions, so it is not suitable for patients with hypotension
Other drugs have the following disadvantages in the treatment of hyperlipidemia: (1) The side effects are large, such as pantothenic acid, stomach discomfort, laxative and other side effects, and those with hyperacidity or ulcer disease should use it with caution
(2) It can cause liver damage, and some drugs can increase blood sugar
(3) It can only be controlled within the normal range and cannot be completely cured
Other non-pharmaceutical products using deep-sea fish oil, seal oil, and seal oil as the main raw materials also have the following disadvantages: (1) It comes from animal fat and is rich in cholesterol. Long-term intake will increase cholesterol in the human body and increase the risk of coronary heart disease
(3) Easy to oxidize, bad taste
(4) Low absorption rate, serious heavy metal pollution, especially mercury pollution
But there are also the following deficiencies: (1) The cost is high, generally tens of thousands of yuan a time, which is difficult for ordinary families to afford
(2) The risk is high, and the safety of plasma input is at risk
(3) The duration is short, and the index does not cure the root cause
It usually lasts for 3-10 months and cannot fundamentally solve the problem of cardiovascular and cerebrovascular diseases

Method used

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  • A pharmaceutical composition, preparation and preparation method for promoting blood circulation, removing blood stasis and lowering blood fat
  • A pharmaceutical composition, preparation and preparation method for promoting blood circulation, removing blood stasis and lowering blood fat
  • A pharmaceutical composition, preparation and preparation method for promoting blood circulation, removing blood stasis and lowering blood fat

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A stasis, hypolipidemic pharmaceutical composition

[0035] Comprising the following raw materials by weight: Ginkgo biloba extract 30g, Pueraria 800g, Salvia 800g, Poria 800g.

[0036] 2, preparation method of the pharmaceutical composition

[0037] Step 1, select qualified Pueraria, Salvia, Poria, according to the ratio that good weight, after washing with water and drain;

[0038] Step 2, the above material was added to water to extract and concentrated to give the concentrate; the extraction conditions: boiled twice, 10 times the first amount of water, extracting two hours; the second 8-fold amount of water, extracting two hours ; and concentrated under reduced pressure and the concentrate is concentrated to the relative density of 1.1 to 1.2, temperature is 70 ℃, the pressure is 0.06 ~ 0.09MPa;

[0039] Step 3, the solution was concentrated and dried to obtain a dry powder; drying conditions of the drying is spray-drying, the spray: inlet temperature 150 ~ 180 ℃, outle...

Embodiment 2

[0043] A stasis, hypolipidemic pharmaceutical composition

[0044] Comprising the following raw materials by weight: Ginkgo biloba extract 50g, Pueraria 600g, Salvia 600g, Poria 600g.

[0045] 2, preparation method of the pharmaceutical composition

[0046] Step 1, select qualified Pueraria, Salvia, Poria, according to the ratio that good weight, after washing with water and drain;

[0047] Step 2, the above material was added to water to extract and concentrated to give the concentrate; the extraction conditions: boiled twice, 10 times the first amount of water, extracting two hours; the second 8-fold amount of water, extracting two hours ; and concentrated under reduced pressure and the concentrate is concentrated to the relative density of 1.1 to 1.2, temperature is 70 ℃, the pressure is 0.06 ~ 0.09MPa;

[0048] Step 3, the solution was concentrated and dried to obtain a dry powder; drying conditions of the drying is spray-drying, the spray: inlet temperature 150 ~ 180 ℃, outle...

Embodiment 3

[0052] A stasis, hypolipidemic pharmaceutical composition

[0053] Comprising the following raw materials by weight: Ginkgo biloba extract 90g, Pueraria 1000g, Salvia 1000g, Poria 1000g.

[0054] 2, preparation method of the pharmaceutical composition

[0055] Step 1, select qualified Pueraria, Salvia, Poria, according to the ratio that good weight, after washing with water and drain;

[0056] Step 2, the above material was added to water to extract and concentrated to give the concentrate; the extraction conditions: boiled twice, 10 times the first amount of water, extracting two hours; the second 8-fold amount of water, extracting two hours ; and concentrated under reduced pressure and the concentrate is concentrated to the relative density of 1.1 to 1.2, temperature is 70 ℃, the pressure is 0.06 ~ 0.09MPa;

[0057] Step 3, the solution was concentrated and dried to obtain a dry powder; drying conditions of the drying is spray-drying, the spray: inlet temperature 150 ~ 180 ℃, ou...

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PUM

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Abstract

The invention discloses a pharmaceutical composition, preparation and preparation method for promoting blood circulation, removing blood stasis, and lowering blood fat. The pharmaceutical composition is made of the following raw materials in parts by weight: 3-10 parts of ginkgo leaf extract, 60-100 parts of kudzu root 60-100 parts of Salvia Miltiorrhiza, 60-100 parts of Poria cocos; the preparation method includes preparing kudzu root, salvia miltiorrhiza, and poria cocos and pretreatment; adding the above materials to water for extraction and concentration to obtain a concentrated solution; drying the concentrated solution Prepare dry powder; mix the dry powder and Ginkgo biloba extract according to the proportion; add pharmaceutically acceptable carriers and / or excipients to the pharmaceutical composition to make pills, ointments, elixirs, tablets, Capsules, oral liquids, powders, and granules; all medicines in this prescription are used in combination, the monarch and the minister work together, and the minister and assistant work together to assist. The efficiency reaches 86.27% and has no toxic and side effects.

Description

Technical field [0001] Technical Field The present invention relates to pharmaceutical compositions, more particularly to a stasis, hypolipidemic pharmaceutical composition, its preparation method. Background technique [0002] With the aging of society and urbanization, population prevalence of unhealthy lifestyles, the risk factors of cardiovascular disease residents of widespread exposure, presented in a younger age, lower income groups and individuals gathered in the fast-growing trend. The next 10 years the number of patients with cardiovascular patients will continue to grow rapidly, according to the number of estimated prevalence of cardiovascular disease is now 290 million. Currently, cardiovascular disease accounts for the death of the first cause of death overall urban and rural residents, rural areas 45.01 percent, the city was 42.61%. The burden of cardiovascular disease gradually worsened since 2004, cardiovascular diseases hospital costs much higher than the average...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P3/06A61P9/00A61P25/00
CPCA61K36/076A61K36/16A61K36/488A61K36/537A61K2236/331A61K2236/39A61K2236/51A61P3/06A61P9/00A61P25/00A61K2300/00
Inventor 王杰
Owner 武汉百理王生物工程有限公司
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