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Moisturizing co-transportation nano composition and preparation method and application thereof

A technology of nanocomposites and hygroscopic agents, which is applied in the field of moisturizing co-delivery nanocomposites and its preparation, can solve the problems of low active ingredient addition, poor skin permeability, easy crystallization and precipitation, etc., to achieve large drug loading, improve Good hydration ability and water dispersibility

Inactive Publication Date: 2018-09-07
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Despite the Wide Variety of Moisturizing Actives, Conventional Moisturizing Creams Still Have Many Problems
The exogenous lipids secreted by the stratum corneum of the skin and the endogenous lipids secreted by the sebaceous gland lipids are both oily substances. Therefore, fat-soluble substances have a higher degree of skin absorption than water-soluble substances, and water-soluble active ingredients have poor skin permeability.
However, most of the moisturizing active ingredients are water-soluble, resulting in a small utilization rate of conventional water-soluble moisturizing skin care products.
Secondly, ceramide can strengthen the skin barrier function, but it is a highly crystalline substance with low solubility and poor water dispersibility, and it is easy to crystallize and precipitate during the storage process. Most of the commercially available ceramide cosmetics are ordinary creams, and the amount of active ingredients added is low. , poor skin permeability, low retention
At present, there are no reports of composite nano-composition products that use physiological lipids, emollients, hygroscopic agents, and biomacromolecules combined with water as effective moisturizing active ingredients.

Method used

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  • Moisturizing co-transportation nano composition and preparation method and application thereof
  • Moisturizing co-transportation nano composition and preparation method and application thereof

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preparation example Construction

[0050] The present invention provides a method for preparing the moisturizing co-delivery nanocomposite described in the above scheme, which includes the following steps:

[0051] In the present invention, liquid oils, emulsifiers, partial co-emulsifiers, physiological lipids, and emollients are mixed and stirred until completely dissolved to obtain an oil phase; the dissolution temperature is preferably 50°C to 75°C, and more It is preferably 55°C to 70°C; the dissolution time is preferably 10 to 30 minutes, more preferably 11 to 20 minutes. In the present invention, the dissolution process preferably uses a water bath to heat and dissolve.

[0052] In the present invention, the biological macromolecules combined with water and the remaining co-emulsifier are evenly mixed and dispersed, then mixed with the moisture absorbent and water, and stirred until completely dissolved to obtain the water phase; the dissolution temperature is preferably 50°C~ 75°C, more preferably 55°C to 70...

Embodiment 1

[0065] Combine 15.0% lauric acid polyethylene glycol glyceride, 20.0% fatty alcohol polyoxyethylene ether, 20.0% coco glucoside, 2.0% octyldodecanol, 8.0% ceramide type 3B, 0.2% wheat germ oil in Stir and dissolve in a water bath at a temperature of 70°C to obtain an oil phase for use;

[0066] Add 3.0% 1,3-butanediol to 3.0% hyaluronic acid to make the dispersion uniform, add 6.0% allantoin and 22.8% water, stir and dissolve in a water bath at a temperature of 70°C to obtain an aqueous phase for use;

[0067] After the oil phase and the water phase are obtained, the oil phase is added dropwise to the water phase at a rate of 2 drops / sec under the condition of a 70°C water bath. During the addition, the stirring rate is controlled to 600 rpm. After the mixing is completed, add 0.05% pentane Alcohol and 0.05% octanoyl hydroxamic acid are emulsified under high-speed shearing at 7000rpm for 9min to prepare micron-level dispersion;

[0068] The micron-level dispersion is subjected to hi...

Embodiment 2

[0071] Combine 5.0% isopropyl palmitate, 10.0% sorbitol laurate, 5.0% ceteareth, 5.0% diethylene glycol monoethyl ether, 10.0% glycerol, 0.5% ceramide type 2, 2.0 % Castor oil is stirred and dissolved in a water bath at a temperature of 55°C to obtain an oil phase for use;

[0072] Add 10.0% 1,3-butanediol to 6.0% hyaluronic acid to make it uniformly dispersed, add 2.0% panthenol and 44.5% water, stir and dissolve in a water bath at a temperature of 55°C to obtain an aqueous phase for use;

[0073] After obtaining the oil phase and the water phase, add the oil phase to the water phase dropwise at a rate of 2 drops / sec under the condition of 55°C water bath. During the dropping process, control the stirring speed to 600 rpm. After the mixing is completed, add 0.5% hexane Alcohol and 0.5% sorbitan caprylate, emulsify at 6000rpm for 3min under high-speed shearing to make a micron-level dispersion;

[0074] The micron-level dispersion is subjected to high-pressure homogenization treatme...

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Abstract

The invention provides a moisturizing co-transportation nano composition and a preparation method and application thereof, and belongs to the technical field of cosmetics. The moisturizing co-transportation nano composition contains the following components in mass percentage: 0.1-10% of physiological lipid, 0.2-10% of an emollient, 0.5-25% of a moisture absorbent, 0.1-6% of biomacromolecules combined with water, 1-20% of liquid grease, 10-50% of emulsifier, 5-30% of co-emulsifier, 0.01-1% of preservative and the balance of water; and the particle size of the moisturizing co-transportation nano composition is 10-500nm. According to the invention, multiple active components with different moisturizing mechanisms are enveloped in a same nano carrier, and therefore, the transdermal co-transportation and cooperated moisturizing effect of multi-target multi-mechanism moisturizing active components is realized, and the dual effects of skin moisturizing and cutin barrier repair are achieved.

Description

Technical field [0001] The invention relates to the technical field of cosmetics, in particular to a moisturizing co-delivery nanocomposite and a preparation method and application thereof. Background technique [0002] As people age, the moisture in the skin gradually loses, leading to abnormal skin metabolism and a series of skin problems such as aging, wrinkles and stains. Therefore, skin moisturizing is the basis of the skin's luster and smooth texture, and it is also the most important indicator of the skin to prevent or delay aging. [0003] An excellent moisturizing cosmetics can not only increase the moisture content of the epidermis, but also repair the damaged skin barrier function, reduce skin dryness and scaling, and make rough skin smooth and soft. Different moisturizing active ingredients have different moisturizing mechanisms in the skin. Currently commonly used skin moisturizing ingredients can be divided into hygroscopic agents, sealants, emollients, and biologic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/88A61K8/73A61K8/68A61K8/60A61K8/49A61K8/06A61P17/00A61P17/06A61Q19/00
CPCA61K8/68A61K8/068A61K8/4913A61K8/4946A61K8/60A61K8/73A61K8/735A61K8/88A61K8/922A61K2800/413A61K2800/72A61P17/00A61P17/06A61Q19/00A61Q19/007
Inventor 刘卫沈慧慧吴培诚闻庆陈家铃
Owner WUHAN BEST CARRIER NANO TECH
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