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Compound ointment preparation and preparation method thereof

An ointment and preparation technology, applied in the field of pharmaceutical preparations, can solve problems such as inability to uniformly disperse, agglomeration and hardening of lidocaine hydrochloride

Inactive Publication Date: 2018-08-24
ZHEJIANG REACHALL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the production process, Vaseline as a matrix is ​​easily affected by the reaction temperature, and causes lidocaine hydrochloride to agglomerate and harden, and cannot be uniformly dispersed in the matrix

Method used

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  • Compound ointment preparation and preparation method thereof

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preparation example Construction

[0039] The preparation method of described glycidyl methacrylate modified carboxymethyl chitosan comprises the following steps:

[0040] Add carboxymethyl chitosan with a number average molecular weight of 9000 and purified water into the reactor, raise the temperature to 50°C, stir for 0.5h, cool down to 30°C, add triethylamine, glycidyl methacrylate, tetrabutyl Ammonium bromide, heat preservation reaction for 72h, and then ethanol precipitation, deionized water dialysis for 48h, freeze-drying at -42°C for 48h, and freeze-drying to obtain the glycidyl methacrylate modified carboxymethyl chitosan; The weight ratio of carboxymethyl chitosan to the purified water, the triethylamine, the glycidyl methacrylate, the tetrabutylammonium bromide, and the dehydrated alcohol is 1:50:3 :5:5:50.

[0041] The preparation method of described glycidyl ether modified carboxymethyl chitosan comprises the following steps:

[0042] Add carboxymethyl chitosan with a number average molecular wei...

Embodiment 1

[0062] The weight of each component in each kilogram of ointment preparation in the described compound ointment preparation comprises: 5 million units of polymyxin B sulfate, 3.5 million units of neomycin sulfate, 500,000 units of bacitracin, 40 g of lidocaine hydrochloride, matrix added to Prescription amount;

[0063] Wherein, the base is white petrolatum, liquid paraffin, α-cyclodextrin, modified chitosan, propylene glycol, methyl p-hydroxybenzoate; the white petrolatum and the liquid paraffin, the α-cyclodextrin , the weight ratio of the modified chitosan, the propylene glycol, and the methyl p-hydroxybenzoate is 1:0.3:0.024:0.16:0.07:0.003; the modified chitosan includes glycidyl methacrylate Ester modified carboxymethyl chitosan, glycidyl ether modified carboxymethyl chitosan, arginine and gluconic acid modified carboxymethyl chitosan; the glycidyl methacrylate modified carboxymethyl chitosan The weight ratio of chitosan to the glycidyl ether modified carboxymethyl chit...

Embodiment 2

[0076] The weight of each component in each kilogram of ointment preparation in the described compound ointment preparation comprises: 5 million units of polymyxin B sulfate, 3.5 million units of neomycin sulfate, 500,000 units of bacitracin, 40 g of lidocaine hydrochloride, matrix added to Prescription amount;

[0077] Wherein, the base is white petrolatum, liquid paraffin, α-cyclodextrin, modified chitosan, propylene glycol, methyl p-hydroxybenzoate; the white petrolatum and the liquid paraffin, the α-cyclodextrin , the weight ratio of the modified chitosan, the propylene glycol, and the methyl p-hydroxybenzoate is 1:0.3:0.024:0.05:0.07:0.003; the modified chitosan includes glycidyl methacrylate Ester modified carboxymethyl chitosan, glycidyl ether modified carboxymethyl chitosan, arginine and gluconic acid modified carboxymethyl chitosan; the glycidyl methacrylate modified carboxymethyl chitosan The weight ratio of chitosan to the glycidyl ether modified carboxymethyl chit...

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Abstract

The invention provides a compound ointment preparation. According to the compound ointment preparation, per kilogram of the compound ointment preparation is prepared from the following components in parts by weight: 250-1000 million units of polymyxin B sulfate, 300-400 million units of neomycin sulfate, 25-75 million units of bacitracin, 30-50 g of lidocaine hydrochloride and a matrix added to the prescription dosage, wherein the matrix is prepared from one or more of white vaseline, yellow vaseline, ozocerite, liquid paraffin, alpha-cyclodextrin, modified chitosan, propylene glycol, methyl parahydroxybenzoats and butylated hydroxytoluene.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular, the invention relates to a compound ointment preparation and a preparation method thereof. Background technique [0002] Transdermal drug delivery system refers to drug delivery on the surface of the skin, so that the drug can penetrate the skin at a certain rate and enter the blood circulation of the human body to produce local or systemic curative effect. Because this type of preparation can effectively avoid the first-pass effect of the liver and the degradation of the drug by the gastrointestinal tract, and reduce the adverse reaction of the drug, it is a hot spot in the research and development of the third-generation drug preparation. Due to the structure of the skin, it is difficult for drugs to diffuse, penetrate, infiltrate and absorb. Increasing the effective area of ​​the transdermal drug delivery system and improving the scalp rate of the drug can p...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61K9/06A61K47/06A61K47/36A61K47/40A61P17/02A61P31/04A61K31/167A61K31/7036
CPCA61K9/0014A61K9/06A61K31/167A61K31/7036A61K38/12A61K47/06A61K47/36A61K47/40A61P17/02A61P31/04A61K2300/00
Inventor 傅龙云张涛铸王富军周亦昌单含文周朱刚吕永军王明燕赵飞松吴海宾
Owner ZHEJIANG REACHALL PHARMA
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