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Metformin hydrochloride cream and preparation method thereof

A technology of metformin hydrochloride and cream, applied in the field of medicine, can solve problems such as interruption of drug treatment

Active Publication Date: 2018-05-04
江苏山信药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These intolerable side effects often lead to discontinuation of drug therapy

Method used

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  • Metformin hydrochloride cream and preparation method thereof
  • Metformin hydrochloride cream and preparation method thereof
  • Metformin hydrochloride cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Metformin Hydrochloride 50g, White Petrolatum 50g, Glyceryl Monostearate 20g, Cetearyl Alcohol 20g, Carbomer 5g, Liquid Paraffin 50g, Tween 60 100g, Propylene Glycol 50g, Glycerin 50g, Methylparaben Add 1g, 5g of benzyl alcohol, and water for injection to 1000g, and accurately weigh according to the above proportions. The cream preparation process is as follows:

[0025] 1) Mix Tween 60, methyl p-hydroxybenzoate, propylene glycol, glycerin and distilled water and heat to 70°C;

[0026] 2) The prescribed amount of metformin hydrochloride and carbomer are dissolved in water;

[0027] 3) Heat cetyl or stearyl alcohol, benzyl alcohol, white petrolatum, glyceryl monostearate, liquid paraffin, and benzyl alcohol in the prescribed amount to 75°C, slowly add the mixture obtained in step 1) and stir quickly, then add 2) Metformin hydrochloride solution, mixed, condensed into a paste.

[0028] Wherein, the content of metformin hydrochloride is 5.0%.

Embodiment 2

[0030] Metformin Hydrochloride 70g, Stearic Acid 20g, Glyceryl Monostearate 50g, Cetyl Alcohol 20g, Carbomer 5g, Liquid Paraffin 50g, Tween 60 100g, Propylene Glycol 80g, Glycerin 20g, Methylparaben Add 1g of ester, 5g of benzyl alcohol, and water for injection to 1000g, and accurately weigh according to the above proportions. The preparation process of the cream is as follows:

[0031] 1) Mix Tween 60, methyl p-hydroxybenzoate, propylene glycol, glycerin and distilled water and heat to 70°C;

[0032] 2) The prescribed amount of metformin hydrochloride and carbomer are dissolved in water;

[0033] 3) Heat cetyl or stearyl alcohol, benzyl alcohol, stearic acid, glyceryl monostearate, and liquid paraffin in the prescribed amount to 75°C, slowly add the mixture obtained in step 1) and stir quickly, then add in step 2) Metformin hydrochloride solution, mixed, condensed into a paste.

[0034] Wherein, the content of metformin hydrochloride is 7.0%.

Embodiment 3

[0036] Metformin hydrochloride 100g, white petrolatum 20g, stearic acid 20g, glyceryl monostearate 50g, carbomer 5g, liquid paraffin 50g, Tween 60 100g, propylene glycol 100g, methyl p-hydroxybenzoate 1g, benzyl alcohol 5g, Add water for injection to 1000g, and accurately weigh according to the above ratio. The cream preparation process is as follows:

[0037] 1) Mix Tween 60, methyl p-hydroxybenzoate, propylene glycol and distilled water and heat to 70°C;

[0038] 2) The prescribed amount of metformin hydrochloride and carbomer are dissolved in water;

[0039] 3) Stearic acid, benzyl alcohol, white petrolatum, glyceryl monostearate, and liquid paraffin in the prescription amount are heated to 75°C, and the mixture obtained in step 1) is slowly added and stirred quickly, then the metformin hydrochloride solution in step 2) is added , mix well, and condense into a paste.

[0040] Wherein, the content of metformin hydrochloride is 10.0%.

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Abstract

The invention discloses metformin hydrochloride cream and a preparation method of the metformin hydrochloride cream. The metformin hydrochloride cream is prepared from the following components: metformin hydrochloride as the active ingredient, an oil-phase solid ingredient, a consistency regulator, a humectant, an emulsifying agent, a skin penetration enhancer, a pH regulator, a preservative, a stabilizer, an aromatic and water, specifically, the metformin hydrochloride cream is prepared from the following components in percentage by mass: 0.1%-10% of metformin hydrochloride, 1%-15% of the oil-phase solid ingredient, 5%-20% of the consistency regulator, 3%-10% of the humectant, 0.5%-5% of the emulsifying agent, the skin penetration enhancer, the pH regulator, the preservative, the stabilizer and the aromatic with the corresponding mass percentages, the balance of water. The invention provides the metformin hydrochloride cream having good skin penetration effect of the active ingredients and high stability, through optimization of the skin penetration enhancer for the cream, the skin penetration efficiency of metformin hydrochloride is improved, and the side effects caused by the medicine are greatly reduced while the blood sugar concentration in the body of a patient is effectively reduced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a metformin hydrochloride cream and a preparation method. Background technique [0002] Metformin Hydrochloride (Metformin Hydrochloride, molecular formula C 4 h 11 N 5 ·HCl), as a classic and effective drug for the treatment of type 2 diabetes, has a history of clinical application for nearly 50 years. Metformin hydrochloride is a hypoglycemic drug that can improve blood sugar tolerance and lower basal and postprandial blood sugar. The mechanism of action of metformin hydrochloride is different from other types of oral hypoglycemic drugs. It can reduce the production of glycogen, reduce the absorption of sugar in the small intestine, and can also increase the uptake and utilization of peripheral sugar, thereby improving insulin sensitivity. After metformin hydrochloride treatment, the total insulin secretion remained unchanged, but decreased fasting insulin levels and daily...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/155A61P3/10
CPCA61K9/0014A61K9/06A61K31/155A61K47/26
Inventor 林山王松杨云松
Owner 江苏山信药业有限公司
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